Results 61 to 70 of about 22,982,554 (304)
A protein quality control pathway regulated by linear ubiquitination
EMBO Journal, 2019 Neurodegenerative diseases are characterized by the accumulation of misfolded proteins in the brain. Insights into protein quality control mechanisms to prevent neuronal dysfunction and cell death are crucial in developing causal therapies.
Eva M. Well +30 more
semanticscholar +1 more source
Protein quality control in the endoplasmic reticulum
Current Opinion in Cell Biology, 2020 Summary Misfolded and mistargeted proteins in the early secretory pathway present significant risks to the cell. A diverse and integrated network of quality control pathways protects the cell from these threats.
B. Phillips +2 more
semanticscholar +1 more source
Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin +17 more
wiley +1 more source
, 2021 Proteins need to be folded into specific three-dimensional conformations to be functional. An extensive network of factors, the protein quality control (PQC) machinery, ensures that the cell maintains a healthy proteome by coordinating their synthesis ...
Schneider, Kara Linda +8 more
core +1 more source
Protein Quality Control by Molecular Chaperones in Neurodegeneration
Frontiers in Neuroscience, 2017 Protein homeostasis (proteostasis) requires the timely degradation of misfolded proteins and their aggregates by protein quality control (PQC), of which molecular chaperones are an essential component.
A. Ciechanover, Y. Kwon
semanticscholar +1 more source
Structure, dynamics and functions of UBQLNs: at the crossroads of protein quality control machinery
Biochemical Journal, 2020 Cells rely on protein homeostasis to maintain proper biological functions. Dysregulation of protein homeostasis contributes to the pathogenesis of many neurodegenerative diseases and cancers.
Tongyin Zheng +2 more
semanticscholar +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Cytomegalovirus (CMV) is a recognized trigger of immune thrombocytopenia (ITP); however, its incidence and impact on disease course in children remain controversial. Therefore, we aimed to characterize the clinical course of pediatric patients with CMV‐associated ITP.
Oded Gilad +9 more
wiley +1 more source
Protein quality control in the endoplasmic reticulum
The Protein Journal, 2019 The site of protein folding and maturation for the majority of proteins that are secreted, localized to the plasma membrane or targeted to endomembrane compartments is the endoplasmic reticulum (ER).
Benjamin M. Adams +2 more
semanticscholar +1 more source
Arsenic Exposure and Compromised Protein Quality Control
Chemical Research in Toxicology, 2020 Exposure to arsenic in contaminated drinking water is a worldwide public health problem that affects more than 200 million people. Protein quality control constitutes an evolutionarily conserved mechanism for promoting proper folding of proteins ...
L. Tam, Yin-Sheng Wang
semanticscholar +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko +5 more
wiley +1 more source