Results 81 to 90 of about 22,982,554 (304)

Protein quality control and regulated proteolysis in the genome‐reduced organism Mycoplasma pneumoniae

Molecular Systems Biology, 2020
Protein degradation is a crucial cellular process in all‐living systems. Here, using Mycoplasma pneumoniae as a model organism, we defined the minimal protein degradation machinery required to maintain proteome homeostasis.
R. Burgos, Marc Weber, Sira Martínez, María Lluch-Senar, L. Serrano   +4 more
semanticscholar   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Nucleolus: A Protein Quality Control Compartment

, 2019
Frottin et al. uncovered a role for the nucleolus as a key quality control compartment that regulates misfolded nuclear proteins. This nonmembrane compartment achieves this by forming liquid-like protein condensates that aid protein refolding in a heat ...
Suresh, S N, Rekulapally, Pavani
core   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Inactive Proteasomes Routed to Autophagic Turnover Are Confined within the Soluble Fraction of the Cell

Biomolecules, 2022
Previous studies demonstrated that dysfunctional yeast proteasomes accumulate in the insoluble protein deposit (IPOD), described as the final deposition site for amyloidogenic insoluble proteins and that this compartment also mediates proteasome ...
Keren Friedman, Ofri Karmon, Uri Fridman, Yair Goldberg, Ophry Pines, Shay Ben-Aroya   +5 more
doaj   +1 more source

Distinct proteostasis circuits cooperate in nuclear and cytoplasmic protein quality control

Nature, 2018
Protein misfolding is linked to a wide array of human disorders, including Alzheimer’s disease, Parkinson’s disease and type II diabetes1,2. Protective cellular protein quality control (PQC) mechanisms have evolved to selectively recognize misfolded ...
Rahul S. Samant, Christine M. Livingston, E. Sontag, J. Frydman   +3 more
semanticscholar   +1 more source

Protein Quality Control Pathways at the Crossroad of Synucleinopathies

Journal of Parkinson's Disease, 2020
The pathophysiology of Parkinson’s disease, dementia with Lewy bodies, multiple system atrophy, and many others converge at alpha-synuclein (α-Syn) aggregation.
E. D. de Mattos, A. Wentink, C. Nussbaum-Krammer, Christian Hansen, Steven Bergink, R. Melki, H. Kampinga   +6 more
semanticscholar   +1 more source

TSP50 Attenuates DSS‐Induced Colitis by Regulating TGF‐β Signaling Mediated Maintenance of Intestinal Mucosal Barrier Integrity

Advanced Science
The integrity of the intestinal mucosal barrier is crucial for protecting the intestinal epithelium against invasion by commensal bacteria and pathogens, thereby combating colitis.
Jiawei Li, Chunxue Niu, Huihan Ai, Xiaoli Li, Linlin Zhang, Yan Lang, Shuyue Wang, Feng Gao, Xianglin Mei, Chunlei Yu, Luguo Sun, Yanxin Huang, Lihua Zheng, Guannan Wang, Ying Sun, Xiaoguang Yang, Zhenbo Song, Yongli Bao   +17 more
doaj   +1 more source

Ubiquitination-activated TAB–TAK1–IKK–NF-κB axis modulates gene expression for cell survival in the lysosomal damage response

eLife
The lysosomal damage response is important for the maintenance of cellular homeostasis in human cells. Although the mechanisms underlying the repair and autophagic elimination of damaged lysosomes have been elucidated, the early signal transduction ...
Akinori Endo, Chikage Takahashi, Naoko Ishibashi, Yasumasa Nishito, Koji Yamano, Keiji Tanaka, Yukiko Yoshida   +6 more
doaj   +1 more source

Studying Spatial Protein Quality Control, Proteopathies, and Aging Using Different Model Misfolding Proteins in S. cerevisiae

Frontiers in Molecular Neuroscience, 2018
Protein quality control (PQC) is critical to maintain a functioning proteome. Misfolded or toxic proteins are either refolded or degraded by a system of temporal quality control and can also be sequestered into aggregates or inclusions by a system of ...
Kara L. Schneider, Thomas Nyström, Per O. Widlund   +2 more
doaj   +1 more source