Results 91 to 100 of about 22,982,554 (304)
UPF1: From mRNA Surveillance to Protein Quality Control
Biomedicines, 2021 Selective recognition and removal of faulty transcripts and misfolded polypeptides are crucial for cell viability. In eukaryotic cells, nonsense-mediated mRNA decay (NMD) constitutes an mRNA surveillance pathway for sensing and degrading aberrant ...
Hyun Jung Hwang +2 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Role of Protein Quality Control Failure in Alcoholic Hepatitis Pathogenesis
, 2017 The mechanisms of protein quality control in hepatocytes in cases of alcoholic hepatitis (AH) including ufmylation, FAT10ylation, metacaspase 1 (Mca1), ERAD (endoplasmic reticulum-associated degradation), JUNQ (juxta nuclear quality control), IPOD ...
Maryam Masouminia +8 more
core +1 more source
Comparative analysis of different biophysical techniques for exosome characterization
Scientific ReportsExosomes, as key mediators of intercellular communication, have demonstrated great potential in drug delivery. However, their accurate characterization remains challenging due to their complex physical properties.
Xiaojuan Yu +9 more
doaj +1 more source
Annual Review of Biochemistry, 2018 Cells must constantly monitor the integrity of their macromolecular constituents. Proteins are the most versatile class of macromolecules but are sensitive to structural alterations.
N. Berner, Karl-Richard Reutter, D. Wolf
semanticscholar +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Water Quality Control Plan. San Francisco Bay Basin (Region 2) [PDF]
, 1986 The State Water Resources Control Board and the nine Regional Water Quality Control Boards were created to solve California\u27s water quality problems. Operating under the provisions of the California Water Code. their unique relationship provides state
California Regional Water Quality Control Board
core
Endoplasmic Reticulum Protein Quality Control in β cells
Seminars in Cell and Developmental Biology, 2020 Type 1 and type 2 diabetes are associated with loss of β cell function. Optimal β cell function is linked to protein homeostasis in the endoplasmic reticulum (ER). Here, we review the roles of ER protein quality-control mechanisms, including the unfolded
N. Shrestha, Rachel B. Reinert, Ling Qi
semanticscholar +1 more source
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source