Results 71 to 80 of about 22,982,554 (304)

The Mitochondrial Hsp90 TRAP1 and Alzheimer’s Disease

Frontiers in Molecular Biosciences, 2021
Alzheimer’s Disease (AD) is the most common form of dementia, characterised by intra- and extracellular protein aggregation. In AD, the cellular protein quality control (PQC) system is derailed and fails to prevent the formation of these aggregates ...
Françoise A. Dekker, Françoise A. Dekker, Françoise A. Dekker, Stefan G. D. Rüdiger, Stefan G. D. Rüdiger   +4 more
doaj   +1 more source

Evidence‐Based Clinical Practice Guidelines for the Management of Pediatric Febrile Neutropenia: Resource‐Sensitive Recommendations for the Asian Continent

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Febrile neutropenia (FN) is a frequent and serious complication in children receiving cancer therapy. Standardizing FN management across Asia is challenging due to variable healthcare infrastructure, diagnostic capacity, and infection patterns; however, it could improve resource use and patient outcomes.
Joliza Patricia Cañeba, Shweta Bansal, Tea Reljic, Allyne Montecillo‐Aguelo, Hamidah Alias, Farrah Amaranto, Maria Stella Aquino‐Calingasan, Bambang Ardianto, Eggi Arguni, Sally Blair, Thi Tam Dang, Maria Beatriz Gepte, Samanmalee Gunasekara, Andini Handayani, Miriam Kimpo, Catherine G. Lam, Nawachai Lertvivatpong, Sergio Licona, Ana Loseo, Ratha Mlis, Vivian Moreno Berrio, Nguyen Hoai Anh, Anna Lisa Ong‐Lim, Ha Thu Pham, Krishna Sagar Sharma, Bun Sereyleak, Sally Jane G. Velasco‐Aro, Su Yadana, Ambuj Kumar, Sheena Mukkada   +29 more
wiley   +1 more source

Molecular mechanisms of mitochondrial quality control

Translational Neurodegeneration
Mitochondria produce adenosine triphosphate (ATP), the main source of cellular energy. To maintain normal function, cells rely on a complex mitochondrial quality control (MQC) system that regulates mitochondrial homeostasis, including mitochondrial ...
Wensheng Li, Yuran Gui, Cui-Ping Guo, Yu-Ting Huang, Yi Liu, Xuan Yu, Hui-liang Zhang, Jian-Zhi Wang, Rong Liu, Y. Mahaman, Qiu-Hong Duan, Xiao-Chuan Wang   +11 more
semanticscholar   +1 more source

Protein quality control in the secretory pathway

Journal of Cell Biology, 2019
One third of the eukaryotic proteome matures in the secretory pathway. Sun and Brodsky describe the machinery that maintains protein fidelity and how its actions are coordinated.
Zhihao Sun, J. Brodsky
semanticscholar   +1 more source

A protein quality control pathway at the mitochondrial outer membrane

eLife, 2020
Maintaining the essential functions of mitochondria requires mechanisms to recognize and remove misfolded proteins. However, quality control (QC) pathways for misfolded mitochondrial proteins remain poorly defined.
M. B. Metzger, Jessica L. Scales, Mitchell F. Dunklebarger, J. Loncarek, A. Weissman   +4 more
semanticscholar   +1 more source

Abatacept for Prophylaxis of Acute and Chronic Graft‐Versus‐Host‐Disease in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation—A Systematic Review and Meta‐Analysis of Cohort Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Graft‐versus‐host disease (GvHD) remains one of the most significant complications of hematopoietic stem cell transplantation (HSCT). Abatacept, a selective T‐cell costimulation modulator, is a relatively novel prophylactic agent, though pediatric data remain limited.
Matthijs D. Kruizinga, Anne B. Verbeek, Caroline A. Lindemans, Emilie P. Buddingh   +3 more
wiley   +1 more source

Effectiveness of Resistance Intradialytic Exercise Compared to Aerobic Intradialytic Exercise for Patients With Chronic Kidney Disease: A Randomized Controlled Clinical Trial

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida, Gisela Cristiane Miyamoto, Daniel da Costa Torres, Ian Setubal Reis Chaves, Jonas do Carmo Paschoalin, Braúlio Lima Nascimento, Luciana Dias Chiavegato   +6 more
wiley   +1 more source

Mitochondrial quality control pathways: PINK1 acts as a gatekeeper

, 2018
© 2017 Published by Elsevier Inc.Mitochondria have a pivotal role in the maintenance of cell homeostasis and survival. Mitochondria are involved in processes such as ATP production, reactive oxygen species production, apoptosis induction, calcium ...
Elvira P. Leites, Vanessa A. Morais, Morais, Vanessa A., Leites, Elvira   +3 more
core   +1 more source

With or without You: Co-Chaperones Mediate Health and Disease by Modifying Chaperone Function and Protein Triage

Cells, 2021
Heat shock proteins (HSPs) are a family of molecular chaperones that regulate essential protein refolding and triage decisions to maintain protein homeostasis.
Selin Altinok, Rebekah Sanchez-Hodge, Mariah Stewart, Kaitlan Smith, Jonathan C. Schisler   +4 more
doaj   +1 more source

A futile battle? Protein quality control and the stress of aging

Developmental Cell, 2018
There exists a phenomenon in aging research whereby early life stress can have positive impacts on longevity. The mechanisms underlying these observations suggest a robust, long-lasting induction of cellular defense mechanisms.
Ryo Higuchi-Sanabria, Phillip A. Frankino, Joseph W. Paul, Sarah U. Tronnes, A. Dillin   +4 more
semanticscholar   +1 more source