Results 1 to 10 of about 1,744,161 (299)
A unifying mechanism for protein transport through the core bacterial Sec machinery [PDF]
Open Biology, 2023 Encapsulation and compartmentalization are fundamental to the evolution of cellular life, but they also pose a challenge: how to partition the molecules that perform biological functions—the proteins—across impermeable barriers into sub-cellular ...
William J. Allen, Ian Collinson
doaj +2 more sources
Regulation of Protein Transport Pathways by the Cytosolic Hsp90s [PDF]
Biomolecules, 2022 The highly conserved molecular chaperone heat shock protein 90 (Hsp90) is well-known for maintaining metastable proteins and mediating various aspects of intracellular protein dynamics. Intriguingly, high-throughput interactome studies suggest that Hsp90
Anna G. Mankovich, Brian C. Freeman
doaj +2 more sources
Protein transport into mitochondria [PDF]
Current Opinion in Microbiology, 1987 Mitochondria are made up of two membrane systems that subdivide this organelle into two aqueous subcompartments: the matrix, which is enclosed by the inner membrane, and the intermembrane space, which is located between the inner and the outer membrane.
Hartl, Franz-Ulrich +3 more
core +4 more sources
Proteomic screen reveals diverse protein transport between connected neurons in the visual system [PDF]
Cell Reports, 2022 Summary: Intercellular transfer of toxic proteins between neurons is thought to contribute to neurodegenerative disease, but whether direct interneuronal protein transfer occurs in the healthy brain is not clear.
Lucio M. Schiapparelli +10 more
doaj +2 more sources
Scientific Reports, 2021 Trichoderma reesei is an ascomycete fungus known for its capability to secrete high amounts of extracellular cellulose- and hemicellulose-degrading enzymes. These enzymes are utilized in the production of second-generation biofuels and T.
Sami Havukainen +5 more
doaj +1 more source
eLife, 2022 Nearly all mitochondrial proteins need to be targeted for import from the cytosol. For the majority, the first port of call is the translocase of the outer membrane (TOM complex), followed by a procession of alternative molecular machines, conducting ...
Holly C Ford +5 more
doaj +1 more source
The ESX-1 Substrate PPE68 Has a Key Function in ESX-1-Mediated Secretion in Mycobacterium marinum
mBio, 2022 Mycobacteria use specialized type VII secretion systems (T7SSs) to secrete proteins across their diderm cell envelope. One of the T7SS subtypes, named ESX-1, is a major virulence determinant in pathogenic species such as Mycobacterium tuberculosis and ...
Merel P. M. Damen +7 more
doaj +1 more source
Bacterial Signal Peptides- Navigating the Journey of Proteins
Frontiers in Physiology, 2022 In 1971, Blobel proposed the first statement of the Signal Hypothesis which suggested that proteins have amino-terminal sequences that dictate their export and localization in the cell.
Sharbani Kaushik +2 more
doaj +1 more source
Biomedicines, 2023 Osteopontin (OPN) is a bioactive integrin-binding protein found in high concentrations in milk, where it is present both as a full-length protein and as several N-terminally derived fragments.
Brian Christensen +5 more
doaj +1 more source
ApoA-I Milano stimulates lipolysis in adipose cells independently of cAMP/PKA activation
Journal of Lipid Research, 2015 ApoA-I, the main protein component of HDL, is suggested to be involved in metabolic homeostasis. We examined the effects of Milano, a naturally occurring ApoA-I variant, about which little mechanistic information is available.
Maria Lindahl +13 more
doaj +1 more source