Results 41 to 50 of about 1,016,451 (162)

Caudo‐rostral brain spreading of α‐synuclein through vagal connections

EMBO Molecular Medicine, 2013
α‐Synuclein accumulation and pathology in Parkinson's disease typically display a caudo‐rostral pattern of progression, involving neuronal nuclei in the medulla oblongata at the earliest stages.
Ayse Ulusoy, Raffaella Rusconi, Blanca I. Pérez‐Revuelta, Ruth E. Musgrove, Michael Helwig, Bettina Winzen‐Reichert, Donato A. Di Monte   +6 more
doaj   +1 more source

Evidence for an Adaptation of a Phage-Derived Holin/Endolysin System to Toxin Transport in Clostridioides difficile

Frontiers in Microbiology, 2018
The pathogenicity locus (PaLoc) of Clostridioides difficile usually comprises five genes (tcdR, tcdB, tcdE, tcdA, tcdC). While the proteins TcdA and TcdB represent the main toxins of this pathogen, TcdR and TcdC are involved in the regulation of their ...
Denise Mehner-Breitfeld, Claudia Rathmann, Thomas Riedel, Thomas Riedel, Ingo Just, Ralf Gerhard, Jörg Overmann, Jörg Overmann, Thomas Brüser   +8 more
doaj   +1 more source

Structural basis for effector transmembrane domain recognition by type VI secretion system chaperones

eLife, 2020
Type VI secretion systems (T6SSs) deliver antibacterial effector proteins between neighboring bacteria. Many effectors harbor N-terminal transmembrane domains (TMDs) implicated in effector translocation across target cell membranes.
Shehryar Ahmad, Kara K Tsang, Kartik Sachar, Dennis Quentin, Tahmid M Tashin, Nathan P Bullen, Stefan Raunser, Andrew G McArthur, Gerd Prehna, John C Whitney   +9 more
doaj   +1 more source

Signal Recognition Particle RNA Contributes to Oxidative Stress Response in Deinococcus radiodurans by Modulating Catalase Localization

Frontiers in Microbiology, 2020
The proper functioning of many proteins requires their transport to the correct cellular compartment or their secretion. Signal recognition particle (SRP) is a major protein transport pathway responsible for the co-translational movement of integral ...
Runhua Han, Jaden Fang, Jessie Jiang, Elena K. Gaidamakova, Elena K. Gaidamakova, Rok Tkavc, Rok Tkavc, Rok Tkavc, Michael J. Daly, Lydia M. Contreras, Lydia M. Contreras   +10 more
doaj   +1 more source

Quantitating the Transfer of the HTLV-1 p8 Protein Between T-Cells by Flow Cytometry

Frontiers in Microbiology, 2018
The Human T-cell leukemia virus type 1 (HTLV-1)-encoded accessory protein p8 is cleaved from the precursor protein p12 encoded by the HTLV-1 open reading frame I. Both p12 and p8 are thought to contribute to efficient viral persistence.
Norbert Donhauser, Stefanie Heym, Andrea K. Thoma-Kress   +2 more
doaj   +1 more source

In Vitro Reconstitution of Functional Type III Protein Export and Insights into Flagellar Assembly

mBio, 2018
The type III secretion system (T3SS) forms the functional core of injectisomes, protein transporters that allow bacteria to deliver virulence factors into their hosts for infection, and flagella, which are critical for many pathogens to reach the site of
Hiroyuki Terashima, Akihiro Kawamoto, Chinatsu Tatsumi, Keiichi Namba, Tohru Minamino, Katsumi Imada   +5 more
doaj   +1 more source

Bovine Serum Albumin Rejection by an Open Ultrafiltration Membrane: Characterization and Modeling

Membranes
The classic application of ultrafiltration (UF) is for the complete retention of proteins, and in that situation, the transport behavior is well established.
Eric Suryawirawan, Anja E. M. Janssen, Remko M. Boom, Albert van der Padt   +3 more
doaj   +1 more source

Regulation of Pollen Tube Growth by Transglutaminase

Plants, 2013
In pollen tubes, cytoskeleton proteins are involved in many aspects of pollen germination and growth, from the transport of sperm cells to the asymmetrical distribution of organelles to the deposition of cell wall material.
Giampiero Cai, Donatella Serafini-Fracassini, Stefano Del Duca   +2 more
doaj   +1 more source

Delineating WWOX Protein Interactome by Tandem Affinity Purification-Mass Spectrometry: Identification of Top Interactors and Key Metabolic Pathways Involved

Frontiers in Oncology, 2018
It has become clear from multiple studies that WWOX (WW domain-containing oxidoreductase) operates as a “non-classical” tumor suppressor of significant relevance in cancer progression.
Tabish Hussain, Jaeho Lee, Martin C. Abba, Junjie Chen, C. Marcelo Aldaz   +4 more
doaj   +1 more source

Human aquaporin-11 guarantees efficient transport of H2O2 across the endoplasmic reticulum membrane

Redox Biology, 2020
Hydrogen peroxide (H2O2) is an essential second intracellular messenger. To reach its targets in the cytosol, H2O2 must cross a membrane, a feat that requires aquaporins (AQP) endowed with ‘peroxiporin’ activity (AQP3, AQP8, AQP9).
Stefano Bestetti, Mauro Galli, Ilaria Sorrentino, Paolo Pinton, Alessandro Rimessi, Roberto Sitia, Iria Medraño-Fernandez   +6 more
doaj   +1 more source