Results 41 to 50 of about 1,744,161 (299)

FGFR1 clustering with engineered tetravalent antibody improves the efficiency and modifies the mechanism of receptor internalization

Molecular Oncology, 2020
Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death.
Marta Pozniak, Aleksandra Sokolowska‐Wedzina, Kamil Jastrzebski, Jakub Szymczyk, Natalia Porebska, Mateusz Adam Krzyscik, Malgorzata Zakrzewska, Marta Miaczynska, Jacek Otlewski, Lukasz Opalinski   +9 more
doaj   +1 more source

Depletion of phosphatidylcholine affects endoplasmic reticulum morphology and protein traffic at the Golgi complex

Journal of Lipid Research, 2009
The mutant Chinese hamster ovary cell line MT58 contains a thermosensitive mutation in CTP:phosphocholine cytidylyltransferase, the regulatory enzyme in the CDP-choline pathway. As a result, MT58 cells have a 50% decrease in their phosphatidylcholine (PC)
Nicole Testerink, Michiel H.M. van der Sanden, Martin Houweling, J. Bernd Helms, Arie B. Vaandrager   +4 more
doaj   +1 more source

Placental transfer of long-chain polyunsaturated fatty acids (LC-PUFA) [PDF]

, 2007
Considerable evidence exists for marked beneficial effects of omega-3 long-chain polyunsaturated fatty acids (LC-PUFA) during pregnancy. The omega-3 LCPUFA docosahexaenoic acid (DHA) is incorporated in large amounts in fetal brain and other tissues ...
Demmelmair, Hans, Koletzko, Berthold, Larqué, Elvira   +2 more
core   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Landscape of nuclear transport receptor cargo specificity

Molecular Systems Biology, 2017
Nuclear transport receptors (NTRs) recognize localization signals of cargos to facilitate their passage across the central channel of nuclear pore complexes (NPCs).
Marie‐Therese Mackmull, Bernd Klaus, Ivonne Heinze, Manopriya Chokkalingam, Andreas Beyer, Robert B Russell, Alessandro Ori, Martin Beck   +7 more
doaj   +1 more source

Type VI secretion: a beginner's guide [PDF]

, 2008
Type VI secretion is a newly described mechanism for protein transport across the cell envelope of Gram-negative bacteria. Components that have been partially characterised include an IcmF homologue, the ATPase ClpV, a regulatory FHA domain protein and ...
Akeda, Baron, Bladergroen, Brzuszkiewicz, Christopher M Bailey, Dandekar, Das, Das, de Bruin, Dreyfus, Dudley, Dudley, Durocher, Economou, Finn, Folkesson, Gardy, Henderson, Johnson, Kulasekara, Lewis EH Bingle, Mark J Pallen, Mougous, Mougous, Nano, Pallen, Parsons, Pukatzki, Pukatzki, Purcell, Roest, Schell, Schlieker, Seshadri, Shalom, Sheahan, Srinivasa Rao, Tatusov, VanRheenen, Ventre, Wang, Weibezahn, Williams, Yahr, Yeo, Zheng, Zheng, Zusman   +47 more
core   +1 more source

Protein Transport by Lung

Experimental Biology and Medicine, 1974
Rabbits were given intravenous injections of L-leucine 4,5/sup 3/H and L- leucine-/sup 12/C. The animals were killed at intervals up to 17h after the last injection and the lungs were removed and lavaged. After the lavage the lungs were minced and homogenized. Proteins were assayed for radioactivity.
K, Dickie, D, Massaro
openaire   +2 more sources

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Enhancing effect of natural adjuvant, panduratin A, on antibacterial activity of colistin against multidrug-resistant Acinetobacter baumannii

Scientific Reports
Colistin- and carbapenem-resistant Acinetobacter baumannii is a serious multidrug resistant (MDR) bacterium in clinical settings. Discovery of new antibacterial drugs against MDR is facing multiple challenges in drug development.
Nalumon Thadtapong, Soraya Chaturongakul, Chanita Napaswad, Padungsri Dubbs, Sunhapas Soodvilai   +4 more
doaj   +1 more source

Non-Markovian Quantum Jumps in Excitonic Energy Transfer [PDF]

, 2009
We utilize the novel non-Markovian quantum jump (NMQJ) approach to stochastically simulate exciton dynamics derived from a time-convolutionless master equation.
Alán Aspuru-Guzik, Breuer H. -P., May V., Patrick Rebentrost, Rupak Chakraborty   +4 more
core   +2 more sources