Results 51 to 60 of about 6,396,996 (306)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Bovine Serum Albumin Rejection by an Open Ultrafiltration Membrane: Characterization and Modeling

Membranes
The classic application of ultrafiltration (UF) is for the complete retention of proteins, and in that situation, the transport behavior is well established.
Eric Suryawirawan, Anja E. M. Janssen, Remko M. Boom, Albert van der Padt   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

TooT-T: discrimination of transport proteins from non-transport proteins [PDF]

BMC Bioinformatics, 2020
Abstract Background Membrane transport proteins (transporters) play an essential role in every living cell by transporting hydrophilic molecules across the hydrophobic membranes. While the sequences of many membrane proteins are known, their structure and function is still not well characterized and understood, owing to the immense effort needed to ...
Munira Alballa, Gregory Butler
openaire   +4 more sources

The characterization of adaptor protein homologues in Plasmodium falciparum [PDF]

, 2009
Includes abstract.Includes bibliographical references (leaves 148-171).Plasmodium falciparum is becoming increasingly more resistant to regular antimalarial drugs, making it necessary to identify novel drug candidates and drug targets.
Meredith, Sandra Allison
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Molecular insights into the transport lectin function of ERGIC-53 [PDF]

, 2004
Secretion of proteins is an essential function of eukaryotic cells. The secretory proteins’ journey along the organelles of the exocytic pathway is initiated by the exit from the endoplasmic reticulum (ER), which defines a major rate-limiting step for ...
Appenzeller-Herzog, Christian
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Neuroinflammation by cytotoxic T-lymphocytes impairs retrograde axonal transport in an oligodendrocyte mutant mouse [PDF]

, 2012
Mice overexpressing proteolipid protein (PLP) develop a leukodystrophy-like disease involving cytotoxic, CD8+ T-lymphocytes. Here we show that these cytotoxic T-lymphocytes perturb retrograde axonal transport.
Groh Janos, Dennis Klein, Spahn, Irene, Klein Dennis, Huber, M., Spahn, I., Ip, Chi Wang, Nave, Klaus-Armin, Diem Ricarda, Groh, J., Ip Chi Wang, Huber, Marianne, Sarah K. Williams, Rudolf Martini, Martini Rudolf, Kroner, A., Janos Groh, Ip, C., Williams, S., Edgar, Julia M., Kroner Antje, Huber Marianne, Ip, C.W., Martini, Rudolf, Nave Klaus-Armin, Martini, R., Antje Kroner, Chi Wang Ip, Diem, Ricarda, Edgar Julia M., Kroner, Antje, Julia M Edgar, Williams, Sarah K., Nave, K., Marianne Huber, Julia M. Edgar, Spahn Irene, Diem, R., Klaus-Armin Nave, Ricarda Diem, Sarah K Williams, Groh, Janos, Klein, Dennis, Klein, D., Edgar, J., Edgar, J.M., Williams Sarah K., Irene Spahn   +47 more
core   +1 more source