Results 61 to 70 of about 6,396,996 (306)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Structural studies of protein deposition in developing legume seeds [PDF]

, 1983
A comparative study of storage protein deposition has been made in developing seeds of a range of legumes. Varieties of pisum sativum, vicia faba, vigna unguiculata, and Phaseolus vulgaris have been examined.
Bakhtiar, A.
core  

Architecture of coatomer: Molecular characterization of delta-COP and protein interactions within the complex [PDF]

, 1996
Copyright © 2011 by The Rockefeller University Press.Coatomer is a cytosolic protein complex that forms the coat of COP I-coated transport vesicles.
Faulstich, D, S Wegchingel, S Auerbach, L Orci, F T Wieland, Wegehingel, S, Ravazzola, M, Auerbach, S, Harter, C, H Tschochner, Stenbeck, G, Lottspeich, F, Wegchingel, S, F Lottspeich, Orci, L, G Stenbeck, Tschochner, H, D Faulstich, C Harter, M Ravazzola, Wieland, FT   +20 more
core   +1 more source

Pan-cancer analysis of TMED2: unraveling potential immune characteristics and prognostic value in cancer therapy

Frontiers in Immunology
BackgroundTransmembrane emp24 domain-containing protein 2 (TMED2) is involved in the sorting and transport of proteins between the Golgi apparatus and the endoplasmic reticulum.
Zhuangzhi Wang, Zhuangzhi Wang, Changning Sun, Pengfei Wang, Shouyang Lin, Shouyang Lin, Xiao Wu, Yuchao Gu   +7 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

The future of interurban passenger transport - bringing citizens closer together: Symposium summary and conclusions. 18th International Symposium on Transport Economics and Policy, Madrid, Spain, 16-18 November 2009 [PDF]

, 2010
The Symposium brought together leading transport researchers from around the world to explore a range of issues under the general theme of 'the future for interurban passenger transport'.
International Transport Forum, OECD
core   +1 more source

Depletion of phosphatidylcholine affects endoplasmic reticulum morphology and protein traffic at the Golgi complex

Journal of Lipid Research, 2009
The mutant Chinese hamster ovary cell line MT58 contains a thermosensitive mutation in CTP:phosphocholine cytidylyltransferase, the regulatory enzyme in the CDP-choline pathway. As a result, MT58 cells have a 50% decrease in their phosphatidylcholine (PC)
Nicole Testerink, Michiel H.M. van der Sanden, Martin Houweling, J. Bernd Helms, Arie B. Vaandrager   +4 more
doaj   +1 more source

FGFR1 clustering with engineered tetravalent antibody improves the efficiency and modifies the mechanism of receptor internalization

Molecular Oncology, 2020
Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death.
Marta Pozniak, Aleksandra Sokolowska‐Wedzina, Kamil Jastrzebski, Jakub Szymczyk, Natalia Porebska, Mateusz Adam Krzyscik, Malgorzata Zakrzewska, Marta Miaczynska, Jacek Otlewski, Lukasz Opalinski   +9 more
doaj   +1 more source

Structural basis for effector transmembrane domain recognition by type VI secretion system chaperones

eLife, 2020
Type VI secretion systems (T6SSs) deliver antibacterial effector proteins between neighboring bacteria. Many effectors harbor N-terminal transmembrane domains (TMDs) implicated in effector translocation across target cell membranes.
Shehryar Ahmad, Kara K Tsang, Kartik Sachar, Dennis Quentin, Tahmid M Tashin, Nathan P Bullen, Stefan Raunser, Andrew G McArthur, Gerd Prehna, John C Whitney   +9 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source