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Therapeutic Nanobodies Targeting Cell Plasma Membrane Transport Proteins: A High-Risk/High-Gain Endeavor [PDF]

open access: yesBiomolecules, 2021
Cell plasma membrane proteins are considered as gatekeepers of the cell and play a major role in regulating various processes. Transport proteins constitute a subclass of cell plasma membrane proteins enabling the exchange of molecules and ions between ...
Raf Van Campenhout   +4 more
doaj   +2 more sources

Transport of Ciliary Membrane Proteins [PDF]

open access: yesFrontiers in Cell and Developmental Biology, 2020
Cilia and flagella are highly conserved organelles in eukaryotic cells that drive cell movement and act as cell antennae that receive and transmit signals.
Huan Long, Kaiyao Huang
doaj   +3 more sources

Membrane Transport Proteins in Osteoclasts: The Ins and Outs [PDF]

open access: yesFrontiers in Cell and Developmental Biology, 2021
During bone resorption, the osteoclast must sustain an extraordinarily low pH environment, withstand immense ionic pressures, and coordinate nutrient and waste exchange across its membrane to sustain its unique structural and functional polarity.
Amy B. P. Ribet   +2 more
doaj   +2 more sources

Single-Molecule FRET of Membrane Transport Proteins. [PDF]

open access: yesChembiochem, 2021
AbstractUncovering the structure and function of biomolecules is a fundamental goal in structural biology. Membrane‐embedded transport proteins are ubiquitous in all kingdoms of life. Despite structural flexibility, their mechanisms are typically studied by ensemble biochemical methods or by static high‐resolution structures, which complicate a ...
Bartels K   +3 more
europepmc   +5 more sources

Multiple novel membrane proteins involve phthalate ester degradation in Rhodococcus sp. AH-ZY2 [PDF]

open access: yesApplied and Environmental Microbiology
Phthalate esters (PAEs) are ubiquitous in the environment, and their microbial metabolism is associated with transport proteins. In this study, multiple novel membrane proteins were identified, revealing their pivotal role in PAEs degradation.
Zhengyu Hou   +7 more
doaj   +2 more sources

Genes for Membrane Transport Proteins: Not So Rare in Viruses [PDF]

open access: yesViruses, 2018
Some viruses have genes encoding proteins with membrane transport functions. It is unknown if these types of proteins are rare or are common in viruses.
Timo Greiner   +3 more
doaj   +2 more sources

Updating view of membrane transport proteins by simulation studies [PDF]

open access: yesBiophysics and Physicobiology, 2023
Takashi Sumikama   +4 more
doaj   +2 more sources

The second intracellular loop of the yeast Trk1 potassium transporter is involved in regulation of activity, and interaction with 14–3-3 proteins

open access: yesComputational and Structural Biotechnology Journal, 2023
Potassium is an essential intracellular ion, and a sufficient intracellular concentration of it is crucial for many processes; therefore it is fundamental for cells to precisely regulate K+ uptake and efflux through the plasma membrane.
Jakub Masaryk   +7 more
doaj   +1 more source

Peroxisomal Metabolite and Cofactor Transport in Humans

open access: yesFrontiers in Cell and Developmental Biology, 2021
Peroxisomes are membrane-bound organelles involved in many metabolic pathways and essential for human health. They harbor a large number of enzymes involved in the different pathways, thus requiring transport of substrates, products and cofactors ...
Serhii Chornyi   +4 more
doaj   +1 more source

Presynaptic Precursor Vesicles—Cargo, Biogenesis, and Kinesin-Based Transport across Species

open access: yesCells, 2023
The faithful formation and, consequently, function of a synapse requires continuous and tightly controlled delivery of synaptic material. At the presynapse, a variety of proteins with unequal molecular properties are indispensable to compose and control ...
Astrid G. Petzoldt
doaj   +1 more source

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