Results 31 to 40 of about 675,421 (190)

Crystal structure of an archaeal CorB magnesium transporter

Nature Communications, 2021
CNNM/CorB proteins are a conserved family of membrane proteins associated with Mg2+ transport. Here, structures of an archaeal CorB protein in apo state and with Mg2+-ATP bound and accompanying biophysical experiments suggest direct Mg2+ transport by ...
Yu Seby Chen, Guennadi Kozlov, Brandon E. Moeller, Ahmed Rohaim, Rayan Fakih, Benoît Roux, John E. Burke, Kalle Gehring   +7 more
doaj   +1 more source

Glycosylation can influence topogenesis of membrane proteins and reveals dynamic reorientation of nascent polypeptides within the translocon [PDF]

, 1999
The topology of multispanning membrane proteins in the mammalian endoplasmic reticulum is thought to be dictated primarily by the first hydrophobic sequence.
Martin Spiess, Veit Goder, Goder, V., Spiess, M., Christoph Bieri, Bieri, C.   +5 more
core   +1 more source

Lipid-mediated activation of plasma membrane-localized deubiquitylating enzymes modulate endosomal trafficking

Nature Communications, 2022
The endocytic degradation of plasma membrane proteins can be modulated by deubiquitylating enzymes (DUBs). Here, the authors describe two plasma membrane localized Arabidopsis DUBs that can be activated by binding to anionic lipids and influence the ...
Karin Vogel, Tobias Bläske, Marie-Kristin Nagel, Christoph Globisch, Shane Maguire, Lorenz Mattes, Christian Gude, Michael Kovermann, Karin Hauser, Christine Peter, Erika Isono   +10 more
doaj   +1 more source

Dynamic insertion of membrane proteins at the endoplasmic reticulum [PDF]

, 2005
Most eukaryotic membrane proteins are cotranslationally integrated into the endoplasmic reticulum membrane by the Sec61 translocation complex. They are targeted to the translocon by hydrophobic signal sequences which induce the translocation of either ...
Higy, Marie
core   +1 more source

Plasma membrane-located purine nucleotide transport proteins are key components for host exploitation by microsporidian intracellular parasites [PDF]

, 2014
EH and TAW acknowledge support from the Marie Curie Fellowship Programme (HTTP://cordis.europa.eu/fp7/home_en.html). ERSK, JML and TME acknowledge support from the Wellcome Trust (www.wellcome.ac.uk/).
Eva Heinz (105025), Hirt, R.P., Edmund R. S. Kunji (669696), Williams, Tom A, Goldberg, A.V., Robert P Hirt, Hacker Christian, T Martin Embley, Robert P. Hirt (124609), Kunji, E.R.S., Nakjang, Sirintra, Hirt, Robert, Kunji, Edmund R S, John M. Lucocq (124603), Embley, T. Martin, Christian Hacker (124601), Edmund R S Kunji, Alina V. Goldberg (124596), Heinz, Eva, John Mifsud (669694), Lucocq, John M., Alison Gregory, Embley T. Martin, Dean, P., Hirt, Robert P., Goldberg, Alina V, Heinz, E., Nakjang Sirintra, T. Martin Embley (124611), Williams Tom A., Sirintra Nakjang (124590), Kunji, Edmund R. S., Kunji, Edmund, John M Lucocq, Gregory, Alison, Goldberg, Alina, Goldberg Alina V., Tom A Williams, Tom A. Williams (124587), Gregory, A., Lucocq John M., Embley, T Martin, Paul Dean (35800), Heinz Eva, Dean, Paul; id_orcid, John Mifsud, Williams, Tom A., Lucocq, John M, Hirt Robert P., Alina V Goldberg, Dean, Paul, Hirt, Robert P, Paul Dean, Nakjang, S., Embley, T, Sirintra Nakjang, Gregory Alison, Dean Paul, Goldberg, Alina V., Mifsud, John, Lucocq, John, Williams, T.A., Mifsud John, Christian Hacker, Alison Gregory (669695), Embley, T.M., Williams, Tom, Eva Heinz, Hacker, Christian, Hacker, C., Kunji, Edmund R.S., Mifsud, J., Kunji Edmund R. S.   +72 more
core   +1 more source

Studies on interactions of exported "plasmodium falciparum" membrane proteins [PDF]

, 2014
Responsible for about 700’000 annual deaths worldwide, malaria today is still one of the major health problems in developing countries. The most deadly form of human malaria called malaria tropica is caused by the apicomplexan parasite Plasmodium ...
Dietz, Olivier
core   +1 more source

Role of SEC14-like phosphatidylinositol transfer proteins in membrane identity and dynamics

Frontiers in Plant Science, 2023
Membrane identity and dynamic processes, that act at membrane sites, provide important cues for regulating transport, signal transduction and communication across membranes.
Karolin Montag, Rumen Ivanov, Petra Bauer, Petra Bauer   +3 more
doaj   +1 more source

Evolution of the Membrane Transport Protein Domain

International Journal of Molecular Sciences, 2022
Membrane transport proteins are widely present in all living organisms, however, their function, transported substrate, and mechanism of action are unknown. Here we use diverse bioinformatics tools to investigate the evolution of MTPs, analyse domain organisation and loop topology, and study the comparative alignment of modelled 3D structures.
Siarhei A. Dabravolski, Stanislav V. Isayenkov   +1 more
openaire   +2 more sources

CDC50 proteins are critical components of the human class-1 P 4-ATPase transport machinery [PDF]

, 2010
Members of the P4 subfamily of P-type ATPases catalyze phospholipid transport and create membrane lipid asymmetry in late secretory and endocytic compartments.
Patricia M. Verhulst, Guillaume Lenoir, Hennrich, H., Lenoir, G.F., Devaux, P.F., Verhulst, P.M., Philippe F. Devaux, Susanne Bryde, Sub Membrane Enzymology begr. 01-06-12, Hanka Hennrich, Joost C.M. Holthuis, Holthuis, J.C.M., Bryde, S., Dep Scheikunde, Membrane Enzymology   +14 more
core   +1 more source

Deletion of Plasmodium falciparum Protein RON3 Affects the Functional Translocation of Exported Proteins and Glucose Uptake

mBio, 2019
The survival of Plasmodium spp. within the host red blood cell (RBC) depends on the function of a membrane protein complex, termed the Plasmodium translocon of exported proteins (PTEX), that exports certain parasite proteins, collectively referred to as ...
Leanne M. Low, Yvonne Azasi, Emma S. Sherling, Matthias Garten, Joshua Zimmerberg, Takafumi Tsuboi, Joseph Brzostowski, Jianbing Mu, Michael J. Blackman, Louis H. Miller   +9 more
doaj   +1 more source