Results 31 to 40 of about 1,016,451 (162)
A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning
eLife, 2015 CRM1 is a highly conserved, RanGTPase-driven exportin that carries proteins and RNPs from the nucleus to the cytoplasm. We now explored the cargo-spectrum of CRM1 in depth and identified surprisingly large numbers, namely >700 export substrates from ...
Koray Kırlı +7 more
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In vivo experiments do not support the charge zipper model for Tat translocase assembly
eLife, 2017 The twin-arginine translocase (Tat) transports folded proteins across the bacterial cytoplasmic membrane and the plant thylakoid membrane. The Tat translocation site is formed by substrate-triggered oligomerization of the protein TatA.
Felicity Alcock +3 more
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Vesicular protein transport [PDF]
The Pharmacogenomics Journal, 2001 Protein transport and sorting in the secretory and endocytic pathways via vesicles is required for organelle biogenesis, constitutive and regulated secretion and constitutive and regulated endocytosis. It is essential for a multicellular organism and the function of its specialised cell types that the multiple transport and sorting events are highly ...
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TooT-T: discrimination of transport proteins from non-transport proteins [PDF]
BMC Bioinformatics, 2020 Abstract Background Membrane transport proteins (transporters) play an essential role in every living cell by transporting hydrophilic molecules across the hydrophobic membranes. While the sequences of many membrane proteins are known, their structure and function is still not well characterized and understood, owing to the immense effort needed to ...
Munira Alballa, Gregory Butler
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Trafficking and localization of Golgi-resident N-glycan processing enzymes in plants
Frontiers in Plant ScienceAsparagine (N)-linked glycosylation is a fundamental co- and post-translational modification of proteins, playing a crucial role in protein folding, stability and function, protein-protein interactions, biotic and abiotic stress response as well as ...
Kai Dünser, Jennifer Schoberer
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Transport of Ciliary Membrane Proteins [PDF]
Frontiers in Cell and Developmental Biology, 2020 Cilia and flagella are highly conserved organelles in eukaryotic cells that drive cell movement and act as cell antennae that receive and transmit signals. In addition to receiving and transducing external signals that activate signal cascades, cilia also secrete ciliary ectosomes that send signals to recipient cells, and thereby mediate cell-cell ...
Huan Long, Kaiyao Huang
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Scientific ReportsColistin- and carbapenem-resistant Acinetobacter baumannii is a serious multidrug resistant (MDR) bacterium in clinical settings. Discovery of new antibacterial drugs against MDR is facing multiple challenges in drug development.
Nalumon Thadtapong +4 more
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Research and Practice in Thrombosis and Haemostasis, 2019 Background Synthesis of the hemostatic protein von Willebrand factor (VWF) drives formation of endothelial storage organelles called Weibel‐Palade bodies (WPBs).
Maaike Schillemans +11 more
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MoleculesSignal transduction and homeostasis are regulated by complex protein interactions in the intracellular environment. Therefore, the transportation of impermeable macromolecules (nucleic acids, proteins, and drugs) that control protein interactions is ...
Akari Miwa, Koki Kamiya
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CoCl2‐induced glioma hypoxia environment enhances CD47‐SIRPα to promote tumor immune evasion
MedComm – OncologyElevated levels of tumor‐associated macrophages and microglia in the immune microenvironment of malignant gliomas promote tumor growth and progression.
Xiangfei Ding +8 more
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