Signal Recognition Particle in Human Diseases [PDF]
Frontiers in Genetics, 2022 The signal recognition particle (SRP) is a ribonucleoprotein complex with dual functions. It co-translationally targets proteins with a signal sequence to the endoplasmic reticulum (ER) and protects their mRNA from degradation.
Morgana K. Kellogg +2 more
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Molecular mechanism of cargo recognition and handover by the mammalian signal recognition particle [PDF]
Cell Reports, 2021 Summary: Co-translational protein targeting to membranes by the signal recognition particle (SRP) is a universally conserved pathway from bacteria to humans.
Ahmad Jomaa +6 more
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Signal recognition particle-dependent secretome in humans [PDF]
Scientific ReportsAbout 30% of all cellular proteins are secreted and membrane proteins. They can be transported by signal recognition particle (SRP)-dependent or SRP-independent mechanisms.
Sarah C. Miller +5 more
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The nucleolar phase of signal recognition particle assembly [PDF]
Life Science AllianceSignal recognition particle (SRP) involved in tethering the ribosome to the endoplasmic reticulum for protein secretion is assembled in part in the nucleolus where it interacts with numerous ribosome assembly factors.
Amani Issa +12 more
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A signal recognition particle receptor gene from the sea cucumber, Apostichopus japonicus [PDF]
Scientific Reports, 2023 The signal recognition particle (SRP) system delivers approximately 30% of the proteome to the endoplasmic reticulum (ER) membrane. SRP receptor alpha (SRα) binds to SRP for targeting nascent secreted proteins to the ER membrane in eukaryotic cells.
Jian Zhang +5 more
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Dynamics of Bacterial Signal Recognition Particle at a Single Molecule Level [PDF]
Frontiers in Microbiology, 2021 We have studied the localization and dynamics of bacterial Ffh, part of the SRP complex, its receptor FtsY, and of ribosomes in the Gamma-proteobacterium Shewanella putrefaciens.
Benjamin Mayer +9 more
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Noncanonical Functions and Cellular Dynamics of the Mammalian Signal Recognition Particle Components [PDF]
Frontiers in Molecular Biosciences, 2021 The signal recognition particle (SRP) is a ribonucleoprotein complex fundamental for co-translational delivery of proteins to their proper membrane localization and secretory pathways.
Camilla Faoro, Sandro F. Ataide
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GTP hydrolysis by complexes of the signal recognition particle and the signal recognition particle receptor. [PDF]
Journal of Cell Biology, 1993 Translocation of proteins across the endoplasmic reticulum membrane is a GTP-dependent process. The signal recognition particle (SRP) and the SRP receptor both contain subunits with GTP binding domains. One GTP-dependent reaction during protein translocation is the SRP receptor-mediated dissociation of SRP from the signal sequence of a nascent ...
Gilmore R
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Signal Recognition Particle Suppressor Screening Reveals the Regulation of Membrane Protein Targeting by the Translation Rate [PDF]
mBio, 2021 Inner membrane proteins (IMPs) are cotranslationally inserted into the inner membrane or endoplasmic reticulum by the signal recognition particle (SRP).
Liuqun Zhao +5 more
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Posttranslational insertion of small membrane proteins by the bacterial signal recognition particle. [PDF]
PLoS Biology, 2020 Small membrane proteins represent a largely unexplored yet abundant class of proteins in pro- and eukaryotes. They essentially consist of a single transmembrane domain and are associated with stress response mechanisms in bacteria. How these proteins are
Ruth Steinberg +12 more
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