Higher nucleoporin-Importinβ affinity at the nuclear basket increases nucleocytoplasmic import. [PDF]
Kidney International, 2013 Several in vitro studies have shown the presence of an affinity gradient in nuclear pore complex proteins for the import receptor Importinβ, at least partially contributing to nucleocytoplasmic transport, while others have historically argued against the
Azimi, Mohammad, Mofrad, Mohammad
core +14 more sources
Expression of intracellular toll-like receptors in leukoplakia and oral squamous cell carcinoma [PDF]
Acta Odontologica ScandinavicaObjective: Toll-like receptors (TLRs) are a group of pathogen recognition receptors expressed not only on immune cells but also cancer cells, where TLR activation may lead to tumour progression or suppression.
Divya Ganesh +7 more
doaj +2 more sources
Widespread nuclear and cytoplasmic accumulation of mutant androgen receptor in SBMA patients [PDF]
Brain, 2005 Spinal and bulbar muscular atrophy (SBMA) is an inherited adult onset motor neuron disease caused by the expansion of a polyglutamine (polyQ) tract within the androgen receptor (AR), affecting only males. The characteristic pathological finding is nuclear inclusions (NIs) consisting of mutant AR with an expanded polyQ in residual motor neurons, and in ...
Hiroaki Adachi +2 more
exaly +3 more sources
The Role of Thyroid Hormone in the Regulation of Cerebellar Development [PDF]
Endocrinology and Metabolism, 2021 The proper organized expression of specific genes in time and space is responsible for the organogenesis of the central nervous system including the cerebellum.
Sumiyasu Ishii +2 more
doaj +1 more source
The Ebola Virus Interferon Antagonist VP24 Undergoes Active Nucleocytoplasmic Trafficking
Viruses, 2021 Viral interferon (IFN) antagonist proteins mediate evasion of IFN-mediated innate immunity and are often multifunctional, with distinct roles in viral replication.
Angela R. Harrison +3 more
doaj +1 more source
Stimulus-dependent regulation of nuclear Ca2+ signaling in cardiomyocytes: a role of neuronal calcium sensor-1. [PDF]
PLoS ONE, 2015 In cardiomyocytes, intracellular calcium (Ca2+) transients are elicited by electrical and receptor stimulations, leading to muscle contraction and gene expression, respectively.
Shu Nakao +2 more
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Frontiers in Cell and Developmental Biology, 2021 Src-homology-2-containing phosphotyrosine phosphatase (SHP2), a classic cytoplasmic protein and a major regulator of receptor tyrosine kinases and G protein-coupled receptors, plays a significant role in preimplantation embryo development. In this study,
Muhammad Idrees +6 more
doaj +1 more source
Transcriptional Regulation of Pyruvate Dehydrogenase Kinase [PDF]
Diabetes & Metabolism Journal, 2012 The pyruvate dehydrogenase complex (PDC) activity is crucial to maintains blood glucose and ATP levels, which largely depends on the phosphorylation status by pyruvate dehydrogenase kinase (PDK) isoenzymes.
Ji Yun Jeong +3 more
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Nuclear and cytoplasmic oestrogen receptors in squamous carcinoma of the cervix [PDF]
British Journal of Cancer, 1981 Nuclear and cytoplasmic oestrogen receptors (REN and REC) were sought in 5 normal cervices and in 43 specimens of squamous carcinoma of the cervix. All 3 tissues components of the 5 normal cervices contained both REN and REC. Thirty-five (81%) of the tumours contained receptors, but in only 9 (21%) were they found in both subcellular compartments ...
W P, Soutter +5 more
openaire +2 more sources
Nucleocytoplasmic Communication in Healthy and Diseased Plant Tissues
Frontiers in Plant Science, 2021 The double membrane of the nuclear envelope (NE) constitutes a selective compartment barrier that separates nuclear from cytoplasmic processes. Plant viability and responses to a changing environment depend on the spatial communication between both ...
Daniel Lüdke +3 more
doaj +1 more source