Importin-β facilitates nuclear import of human GW proteins and balances cytoplasmic gene silencing protein levels [PDF]
Nucleic Acids Research, 2015 MicroRNAs (miRNAs) guide Argonaute (Ago) proteins to distinct target mRNAs leading to translational repression and mRNA decay. Ago proteins interact with a member of the GW protein family, referred to as TNRC6A-C in mammals, which coordinate downstream ...
Daniel Schraivogel +7 more
semanticscholar +2 more sources
Expression of intracellular toll-like receptors in leukoplakia and oral squamous cell carcinoma [PDF]
Acta Odontologica ScandinavicaObjective: Toll-like receptors (TLRs) are a group of pathogen recognition receptors expressed not only on immune cells but also cancer cells, where TLR activation may lead to tumour progression or suppression.
Divya Ganesh +7 more
doaj +2 more sources
The Role of Thyroid Hormone in the Regulation of Cerebellar Development [PDF]
Endocrinology and Metabolism, 2021 The proper organized expression of specific genes in time and space is responsible for the organogenesis of the central nervous system including the cerebellum.
Sumiyasu Ishii +2 more
doaj +1 more source
Cytoplasmic and Nuclear Functions of cIAP1
Biomolecules, 2022 Cellular inhibitor of apoptosis 1 (cIAP1) is a cell signaling regulator of the IAP family. Through its E3-ubiquitine ligase activity, it has the ability to activate intracellular signaling pathways, modify signal transduction pathways by changing protein-
Aymeric Zadoroznyj, L. Dubrez
semanticscholar +1 more source
The Ebola Virus Interferon Antagonist VP24 Undergoes Active Nucleocytoplasmic Trafficking
Viruses, 2021 Viral interferon (IFN) antagonist proteins mediate evasion of IFN-mediated innate immunity and are often multifunctional, with distinct roles in viral replication.
Angela R. Harrison +3 more
doaj +1 more source
Stimulus-dependent regulation of nuclear Ca2+ signaling in cardiomyocytes: a role of neuronal calcium sensor-1. [PDF]
PLoS ONE, 2015 In cardiomyocytes, intracellular calcium (Ca2+) transients are elicited by electrical and receptor stimulations, leading to muscle contraction and gene expression, respectively.
Shu Nakao +2 more
doaj +1 more source
Quantitative estimates of cytoplasmic and nuclear oestrogen receptors in chick oviduct. Effect of oestrogen on receptor concentration and subcellular distribution. [PDF]
European Journal of Biochemistry, 1976 [3H]Oestradiol exchange techniques were developed for the determination of specific cestrogen receptor site concentrations in the cytoplasm and nuclei of chick oviduct cells. Non‐labelled receptor‐bound oestrogens were exchanged with [3H]oestradiol during a 24‐h incubation at 20 °C. 2 h at 30 °C or 45 min at 37 °C.
Robert L. Sutherland, E. Baulieu
semanticscholar +3 more sources
Molecular and Cellular Biology, 2016 Nuclear-cytoplasmic transport through nuclear pore complexes is mediated by nuclear transport receptors. Previous reports have suggested that aberrant nuclear-cytoplasmic transport due to mutations or overexpression of nuclear pore complexes and nuclear ...
Shoko Saito +3 more
semanticscholar +2 more sources
Nuclear and cytoplasmic oestrogen receptors in squamous carcinoma of the cervix [PDF]
British Journal of Cancer, 1981 Nuclear and cytoplasmic oestrogen receptors (REN and REC) were sought in 5 normal cervices and in 43 specimens of squamous carcinoma of the cervix. All 3 tissues components of the 5 normal cervices contained both REN and REC. Thirty-five (81%) of the tumours contained receptors, but in only 9 (21%) were they found in both subcellular compartments ...
W P, Soutter +5 more
openaire +2 more sources
Transcriptional Regulation of Pyruvate Dehydrogenase Kinase [PDF]
Diabetes & Metabolism Journal, 2012 The pyruvate dehydrogenase complex (PDC) activity is crucial to maintains blood glucose and ATP levels, which largely depends on the phosphorylation status by pyruvate dehydrogenase kinase (PDK) isoenzymes.
Ji Yun Jeong +3 more
doaj +1 more source