Results 21 to 30 of about 166,825 (267)
Cytoplasmic TRAIL-R1 is a positive prognostic marker in PDAC
BMC Cancer, 2018 Background The death receptors TRAIL-R1 and TRAIL-R2 are frequently overexpressed in cancer and there is an emerging evidence for their important role in malignant progression, also in the case of pancreatic ductal adenocarcinoma (PDAC).
Jan-Paul Gundlach +9 more
doaj +1 more source
NDP52 activates nuclear myosin VI to enhance RNA polymerase II transcription
Nature Communications, 2017 Myosin VI (MVI) is known to interact with RNA Polymerase II and to play non-cytoplasmic roles in cells. Here, the authors provide evidence that the transcription co-activator NDP52 regulates MVI binding to DNA and that MVI interacts with nuclear ...
Natalia Fili +7 more
doaj +1 more source
BMC Cancer, 2006 Background Overexpression of Fra-1 in fibroblasts causes anchorage-independent cell growth and oncogenic transformation. A high level of Fra-1 expression is found in various tumors and tumorigenic cell lines, suggesting that Fra-1 may be involved in ...
Chen Liyong +9 more
doaj +1 more source
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2005 The constitutive androstane receptor (CAR) is a ligand/activator-dependent transactivation factor that resides in the cytoplasm and forms part of an as yet unidentified protein complex. Upon stimulation, CAR translocates into the nucleus where it modulates the transactivation of target genes.
Kanno, Yuichiro +3 more
openaire +2 more sources
PLoS ONE, 2012 NTF2 is a cytosolic protein responsible for nuclear import of Ran, a small Ras-like GTPase involved in a number of critical cellular processes, including cell cycle regulation, chromatin organization during mitosis, reformation of the nuclear envelope following mitosis, and controlling the directionality of nucleocytoplasmic transport.
Shawn C Chafe +2 more
openaire +4 more sources
Cells, 2020 Growth factors and cytokines have vital roles in germ cell development, gamete maturation, and early embryo development. Cell surface receptors are present for growth factors and cytokines to integrate with and trigger protein signaling in the germ and ...
Muhammad Idrees +6 more
doaj +1 more source
Translational Oncology, 2018 New markers are needed to improve diagnosis and to personalize treatments for patients with breast cancer (BC). Receptor-interacting protein of 140 kDa (RIP140) and ligand-dependent corepressor (LCoR), two transcriptional co-regulators of estrogen ...
Sophie Sixou +9 more
doaj +1 more source
Understanding Bile Acid Signaling in Diabetes: From Pathophysiology to Therapeutic Targets [PDF]
Diabetes & Metabolism Journal, 2019 Diabetes and obesity have reached an epidemic status worldwide. Diabetes increases the risk for cardiovascular disease and non-alcoholic fatty liver disease. Primary bile acids are synthesized in hepatocytes and are transformed to secondary bile acids in
Jessica M. Ferrell, John Y. L. Chiang
doaj +1 more source
Specific nuclear localizing sequence directs two myosin isoforms to the cell nucleus in calmodulin-sensitive manner. [PDF]
PLoS ONE, 2012 BACKGROUND: Nuclear myosin I (NM1) was the first molecular motor identified in the cell nucleus. Together with nuclear actin, they participate in crucial nuclear events such as transcription, chromatin movements, and chromatin remodeling.
Rastislav Dzijak +6 more
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A Study of Cytoplasmic and Nuclear Estrogen and Progestin Receptors in Gynecologic Neoplasms
Endocrinologia Japonica, 1987 A rapid method for simultaneous preparation of cytosol and nuclear estrogen (E) and progestin (P) receptors and their in vitro determination is described. The method was applied to several uterine or ovarian surgical specimens to evaluate their steroid hormone "dependence". The results suggest that low cytoplasmic E receptor levels (ERc) are associated
SAKAMOTO, H. +6 more
openaire +3 more sources