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Genome-Directed Cell Nucleus Assembly [PDF]
Biology, 2022 The cell nucleus is frequently considered a cage in which the genome is placed to protect it from various external factors. Inside the nucleus, many functional compartments have been identified that are directly or indirectly involved in implementing ...
Sergey V. Razin, Sergey V. Ulianov
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Mechanobiology of the cell nucleus [PDF]
APL Bioengineering, 2022 Jan Lammerding +2 more
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The Material Properties of the Cell Nucleus: A Matter of Scale [PDF]
Cells, 2023 Chromatin regulatory processes physically take place in the environment of the cell nucleus, which is filled with the chromosomes and a plethora of smaller biomolecules.
Maud Hertzog, Fabian Erdel
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Lamin A/C and PI(4,5)P2—A Novel Complex in the Cell Nucleus [PDF]
CellsLamins, the nuclear intermediate filaments, are important regulators of nuclear structural integrity as well as nuclear functional processes such as DNA transcription, replication and repair, and epigenetic regulations.
Sara Escudeiro-Lopes +3 more
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Physical Training Chronically Stimulates the Motor Neuron Cell Nucleus in the Ts65Dn Mouse, a Model of Down Syndrome [PDF]
Cells, 2023 Down syndrome (DS) is a genetically-based disease based on the trisomy of chromosome 21 (Hsa21). DS is characterized by intellectual disability in association with several pathological traits among which early aging and altered motor coordination are ...
Chiara Rita Inguscio +4 more
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Mitochondrial TFAM as a Signaling Regulator between Cellular Organelles: A Perspective on Metabolic Diseases [PDF]
Diabetes & Metabolism Journal, 2021 Tissues actively involved in energy metabolism are more likely to face metabolic challenges from bioenergetic substrates and are susceptible to mitochondrial dysfunction, leading to metabolic diseases.
Jin-Ho Koh +3 more
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Cells, 2022 The focal adhesion protein Vinculin (VCL) is ascribed to various cytoplasmic functions; however, its nuclear role has so far been ambiguous. We observed that VCL localizes to the nuclei of mouse primary spermatocytes undergoing first meiotic division ...
Jana Petrusová +7 more
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PIP2-Effector Protein MPRIP Regulates RNA Polymerase II Condensation and Transcription
Biomolecules, 2023 The specific post-translational modifications of the C-terminal domain (CTD) of the Rpb1 subunit of RNA polymerase II (RNAPII) correlate with different stages of transcription.
Can Balaban +5 more
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Nucleoporin TPR Affects C2C12 Myogenic Differentiation via Regulation of Myh4 Expression
Cells, 2021 The nuclear pore complex (NPC) has emerged as a hub for the transcriptional regulation of a subset of genes, and this type of regulation plays an important role during differentiation.
Jana Uhlířová +5 more
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Cells, 2021 Here, we provide evidence for the presence of Myosin phosphatase rho-interacting protein (MPRIP), an F-actin-binding protein, in the cell nucleus. The MPRIP protein binds to Phosphatidylinositol 4,5-bisphosphate (PIP2) and localizes to the nuclear ...
Can Balaban +3 more
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