Results 1 to 10 of about 13,190 (254)
Phosphoinositides in plant-pathogen interaction: trends and perspectives
Stress Biology, 2023 Phosphoinositides are important regulatory membrane lipids, with a role in plant development and cellular function. Emerging evidence indicates that phosphoinositides play crucial roles in plant defence and are also utilized by pathogens for infection ...
Supriya Chakraborty +2 more
exaly +2 more sources
Phosphoinositides in the kidney [PDF]
Journal of Lipid Research, 2019 Phosphoinositides (PIs) play pivotal roles in the regulation of many biological processes. The quality and quantity of PIs is regulated in time and space by the activity of PI kinases and PI phosphatases. The number of PI-metabolizing enzymes exceeds the
Leopoldo Staiano +1 more
doaj +4 more sources
Phosphoinositides as membrane organizers
Nature Reviews Molecular Cell Biology, 2022 Phosphoinositides are signalling lipids derived from phosphatidylinositol, a ubiquitous phospholipid in the cytoplasmic leaflet of eukaryotic membranes. Initially discovered for their roles in cell signalling, phosphoinositides are now widely recognized as key integrators of membrane dynamics that broadly impact on all aspects of cell physiology and on
York Posor +2 more
exaly +3 more sources
Acutely Modifying Phosphatidylinositol Phosphates on Endolysosomes Using Chemically Inducible Dimerization Systems [PDF]
Bio-ProtocolPhosphoinositides are rare membrane lipids that mediate cell signaling and membrane dynamics. PI(4)P and PI(3)P are two major phosphoinositides crucial for endolysosomal functions and dynamics, making them the lipids of interest in many studies.
Wei Sheng Yap, Peter Kim, Maxime Boutry
doaj +2 more sources
Lipidation as a post-translational code for protein liquid-liquid phase separation [PDF]
Journal of Lipid ResearchLiquid–liquid phase separation has emerged as a central organizing mechanism that drives the formation of biomolecular condensates and enables cells to spatially and temporally coordinate metabolism, signaling, and gene expression. While the influence of
Soodabeh Abbasi Sani +2 more
doaj +2 more sources
Assessing the Presence of Phosphoinositides on Autophagosomal Membrane in Yeast by Live Cell Imaging [PDF]
MicroorganismsThe formation of autophagosomes mediating the sequestration of cytoplasmic materials is the central step of autophagy. Several phosphoinositides, which are signaling molecules on the membrane, are involved in autophagy.
Jing-Zhen Song +5 more
doaj +2 more sources
Frontiers in Cell and Developmental Biology, 2021 Primary cilia are evolutionary conserved microtubule-based organelles that protrude from the surface of most mammalian cells. Phosphoinositides (PI) are membrane-associated signaling lipids that regulate numerous cellular events via the recruitment of ...
Sarah E. Conduit +4 more
doaj +1 more source
When PIP2 Meets p53: Nuclear Phosphoinositide Signaling in the DNA Damage Response
Frontiers in Cell and Developmental Biology, 2022 The mechanisms that maintain genome stability are critical for preventing tumor progression. In the past decades, many strategies were developed for cancer treatment to disrupt the DNA repair machinery or alter repair pathway selection.
Yu-Hsiu Wang, Michael P. Sheetz
doaj +1 more source
Phosphoinositides and phagocytosis [PDF]
The Journal of Cell Biology, 2001 Phosphoinositide 3 kinases (PI3Ks)**Abbreviation used in this paper: PI3K, phosphoinositide 3 kinase. are known as regulators of phagocytosis. Recent results demonstrate that class I and III PI3Ks act consecutively in phagosome formation and maturation, and that their respective products, phosphatidylinositol 3,4,5-trisphosphate (PI[3,4,5]P3) and ...
Gillooly, David J. +2 more
openaire +2 more sources
Key role of polyphosphoinositides in dynamics of fusogenic nuclear membrane vesicles. [PDF]
PLoS ONE, 2011 The role of phosphoinositides has been thoroughly described in many signalling and membrane trafficking events but their function as modulators of membrane structure and dynamics in membrane fusion has not been investigated.
Vanessa Zhendre +5 more
doaj +1 more source