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Acutely Modifying Phosphatidylinositol Phosphates on Endolysosomes Using Chemically Inducible Dimerization Systems [PDF]
Bio-ProtocolPhosphoinositides are rare membrane lipids that mediate cell signaling and membrane dynamics. PI(4)P and PI(3)P are two major phosphoinositides crucial for endolysosomal functions and dynamics, making them the lipids of interest in many studies.
Wei Sheng Yap, Peter Kim, Maxime Boutry
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Lipidation as a post-translational code for protein liquid-liquid phase separation [PDF]
Journal of Lipid ResearchLiquid–liquid phase separation has emerged as a central organizing mechanism that drives the formation of biomolecular condensates and enables cells to spatially and temporally coordinate metabolism, signaling, and gene expression. While the influence of
Soodabeh Abbasi Sani +2 more
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Phosphoinositides as membrane organizers
Nature Reviews Molecular Cell Biology, 2022 Phosphoinositides are signalling lipids derived from phosphatidylinositol, a ubiquitous phospholipid in the cytoplasmic leaflet of eukaryotic membranes. Initially discovered for their roles in cell signalling, phosphoinositides are now widely recognized as key integrators of membrane dynamics that broadly impact on all aspects of cell physiology and on
York Posor, Wonyul Jang, Volker Haucke
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Assessing the Presence of Phosphoinositides on Autophagosomal Membrane in Yeast by Live Cell Imaging [PDF]
MicroorganismsThe formation of autophagosomes mediating the sequestration of cytoplasmic materials is the central step of autophagy. Several phosphoinositides, which are signaling molecules on the membrane, are involved in autophagy.
Jing-Zhen Song +5 more
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Frontiers in Cell and Developmental Biology, 2021 Primary cilia are evolutionary conserved microtubule-based organelles that protrude from the surface of most mammalian cells. Phosphoinositides (PI) are membrane-associated signaling lipids that regulate numerous cellular events via the recruitment of ...
Sarah E. Conduit +4 more
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When PIP2 Meets p53: Nuclear Phosphoinositide Signaling in the DNA Damage Response
Frontiers in Cell and Developmental Biology, 2022 The mechanisms that maintain genome stability are critical for preventing tumor progression. In the past decades, many strategies were developed for cancer treatment to disrupt the DNA repair machinery or alter repair pathway selection.
Yu-Hsiu Wang, Michael P. Sheetz
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The proppin Bcas3 and its interactor KinkyA localize to the early phagophore and regulate autophagy [PDF]
, 2021 To resolve the signaling mechanisms that mediate the starvation-induced processes of Dictyostelium sporulation and encystation, we performed insertional mutagenesis on cells harboring an mRFP-tagged spore gene.
Schaap, Pauline, Yamada, Yoko
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Phosphoinositides in plant-pathogen interaction: trends and perspectives
Stress Biology, 2023 Phosphoinositides are important regulatory membrane lipids, with a role in plant development and cellular function. Emerging evidence indicates that phosphoinositides play crucial roles in plant defence and are also utilized by pathogens for infection ...
Fauzia Zarreen +2 more
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PHOSPHOINOSITIDE KINASES [PDF]
Annual Review of Biochemistry, 1998 Phosphatidylinositol, a component of eukaryotic cell membranes, is unique among phospholipids in that its head group can be phosphorylated at multiple free hydroxyls. Several phosphorylated derivatives of phosphatidylinositol, collectively termed phosphoinositides, have been identified in eukaryotic cells from yeast to mammals.
D A, Fruman, R E, Meyers, L C, Cantley
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Phosphatidylinositol (4,5)-bisphosphate turnover by INP51 regulates the cell wall integrity pathway in "Saccharomyces cerevisiae" [PDF]
, 2004 Signal transduction pathways are important for the cell to transduce external or internal stimuli where second messengers play an important role as mediators of the stimuli. One important group of second messengers are the phosphoinositide family present
Morales-Johansson, Helena
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