Biochemistry and structure of phosphoinositide phosphatases [PDF]
BMB Reports, 2013 Phosphoinositides are the phosphorylated derivatives ofphosphatidylinositol, and play a very significant role in adiverse range of signaling processes in eukaryotic cells.
Young Yil Bahk +2 more
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Functions and Mechanisms of SAC Phosphoinositide Phosphatases in Plants [PDF]
Frontiers in Plant Science, 2021 Phosphatidylinositol (PtdIns) is one type of phospholipid comprising an inositol head group and two fatty acid chains covalently linked to the diacylglycerol group.
Shutang Tan, Tan Shutang
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A new family of phosphoinositide phosphatases in microorganisms: identification and biochemical analysis [PDF]
BMC Genomics, 2010 Background Phosphoinositide metabolism is essential to membrane dynamics and impinges on many cellular processes, including phagocytosis. Modulation of phosphoinositide metabolism is important for pathogenicity and virulence of many human pathogens ...
Lydia Tabernero +2 more
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Phosphoinositide phosphatases and disease [PDF]
Journal of Lipid Research, 2009 The field of inositol signaling has expanded greatly in recent years. Given the many reviews on phosphoinositide kinases, we have chosen to restrict our discussion to inositol lipid hydrolysis focused on the phosphatases and a brief mention of the lipase
Philip W. Majerus, John D. York
doaj +4 more sources
Dysregulation of Phosphoinositide 5-Phosphatases and Phosphoinositides in Alzheimer's Disease [PDF]
Frontiers in Neuroscience, 2021 info:eu-repo/semantics ...
Christophe Erneux +2 more
exaly +7 more sources
Phosphoinositide phosphatases in cell biology and disease [PDF]
Progress in Lipid Research, 2010 Phosphoinositides are essential signaling molecules linked to a diverse array of cellular processes in eukaryotic cells. The metabolic interconversions of these phospholipids are subject to exquisite spatial and temporal regulation executed by arrays of phosphatidylinositol (PtdIns) and phosphoinositide-metabolizing enzymes.
Vytas Bankaitis
exaly +5 more sources
Non-redundant roles of the phosphoinositide phosphatases PTEN and PIPP in PI3K/AKT signaling in breast cancer [PDF]
Communications BiologyPhosphoinositide 3-kinase (PI3K) signaling is hyperactivated in ~70% of breast cancers via mutations in oncogenes including PIK3CA or inactivation/depletion of phosphoinositide (PI)-phosphatases.
Lisa M. Ooms +11 more
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Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases. [PDF]
Biosci Rep, 2017 Class I phosphoinositide 3-kinase (PI3K) generates phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) at the plasma membrane in response to growth factors, activating a signalling cascade that regulates many cellular functions including cell growth, proliferation, survival, migration and metabolism.
Rodgers SJ +3 more
europepmc +4 more sources
The structure of phosphoinositide phosphatases: Insights into substrate specificity and catalysis. [PDF]
Biochim Biophys Acta, 2015 Phosphoinositides (PIs) are a group of key signaling and structural lipid molecules involved in a myriad of cellular processes. PI phosphatases, together with PI kinases, are responsible for the conversion of PIs between distinctive phosphorylation states.
Hsu F, Mao Y.
europepmc +4 more sources
The impact of phosphoinositide 5-phosphatases on phosphoinositides in cell function and human disease [PDF]
Journal of Lipid Research, 2019 Phosphoinositides (PIs) are recognized as major signaling molecules in many different functions of eukaryotic cells. PIs can be dephosphorylated by multiple phosphatase activities at the 5-, 4-, and 3- positions.
Ana Raquel Ramos +2 more
doaj +3 more sources