Results 1 to 10 of about 5,717 (90)

A review on age‐related cancer risks in PTEN hamartoma tumor syndrome

Clinical Genetics, 2021
This review summarizes the evidence on age‐related cancer risks for PHTS patients. Females have predominantly a strong increased risk and earlier age at onset for breast, endometrial, and thyroid cancer, and males for thyroid cancer. The risks of other PHTS‐associated cancers are uncertain.
Linda A J Hendricks, Nicoline Hoogerbrugge, Janneke H M Schuurs-Hoeijmakers   +2 more
exaly   +2 more sources

Subcellular targeting and dynamic regulation of PTEN: implications for neuronal cells and neurological disorders

Frontiers in Molecular Neuroscience, 2014
PTEN is a lipid and protein phosphatase that regulates a diverse range of cellular mechanisms. PTEN is mainly present in the cytosol and transiently associates with the plasma membrane to dephosphorylate PI(3,4,5)P3, thereby antagonizing the PI3-Kinase ...
Britta J Eickholt, Ivo Lieberam
exaly   +3 more sources

Brain patterning perturbations following PTEN loss

Frontiers in Molecular Neuroscience, 2014
This review will consider the impact of compromised PTEN signaling in brain patterning. We approach understanding the contribution of PTEN to nervous system development by surveying the findings from the numerous genetic loss-of-function models that have
Biliana O Veleva-Rotse, Anthony P Barnes
exaly   +3 more sources

Follicular thyroid carcinoma metastatic to skin: a small papule and a big diagnostic change [PDF]

Anais Brasileiros de Dermatologia, 2019
: Cutaneous metastases are uncommon in daily practice, although very important, since they may be the first manifestation of an undiscovered primary neoplasm or the first indication of recurrence.
Marcia Lanzoni Alvarenga Lira, Mariana Abdo de Almeida, Michele Maria Reis-Feroldi, Jeanine Alvarenga Rocha   +3 more
doaj   +2 more sources

The Concise Guide to PHARMACOLOGY 2023/24: Enzymes

British Journal of Pharmacology, Volume 180, Issue S2, Page S289-S373, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jurg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +28 more
wiley   +1 more source

The impact of PIK3CA mutations and PTEN expression on the effect of neoadjuvant therapy for postmenopausal luminal breast cancer patients

BMC Cancer, 2023
Background There is pressing needs to find the biomarker in the selection of neoadjuvant therapy in postmenopausal luminal breast cancer patients. We examined the hypothesis that PIK3CA mutations and low phosphatase and tensin homolog (PTEN) expression ...
Shouko Hayama, Rikiya Nakamura, Takayuki Ishige, Takafumi Sangai, Masahiro Sakakibara, Hiroshi Fujimoto, Emi Ishigami, Takahito Masuda, Ayako Nakagawa, Ryotaro Teranaka, Satoshi Ota, Sakae Itoga, Naohito Yamamoto, Takeshi Nagashima, Masayuki Otsuka   +14 more
doaj   +1 more source

Global gene expression analysis of pigeonpea with male sterility conditioned by A2 cytoplasm

The Plant Genome, Volume 14, Issue 3, November 2021., 2021
Abstract Cytoplasmic male sterility(CMS), a maternally inherited trait, provides a promising means to harness yield gains associated with hybrid vigor. In pigeonpea [Cajanus cajan (L.) Huth], nine types of sterility‐inducing cytoplasm have been reported, of which A2 and A4 have been successfully deployed in hybrid breeding.
Abhishek Bohra, Gandam Prasad, Abhishek Rathore, Rachit K Saxena, Satheesh Naik SJ, Shalini Pareek, Rintu Jha, Lekha Pazhamala, Dibendu Datta, Gaurav Pandey, Abha Tiwari, Alok Kumar Maurya, Khela Ram Soren, Mohd Akram, Rajeev K Varshney, Narendra P Singh   +15 more
wiley   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes

British Journal of Pharmacology, Volume 178, Issue S1, Page S313-S411, October 2021., 2021
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets ...
Stephen P H Alexander, Doriano Fabbro, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Christopher Southan, Jamie A Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Doris Koesling, Rennolds Ostrom, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Michael Russwurm, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +32 more
wiley   +1 more source

Loss of PTEN expression and AKT activation in HER2-positive breast carcinomas [PDF]

Revista Brasileira de Ginecologia e Obstetrícia, 2014
PURPOSE: To examine the expression of AKT and PTEN in a series of HER2-positive primary invasive breast tumors using immunohistochemistry, and to associate these expression profiles with classic pathologic features such as tumor grade, hormone receptor ...
Francini de Mattos Lima Lin, Carlos Eduardo Bacchi, Edmund Chada Baracat, Filomena Marino Carvalho   +3 more
doaj   +1 more source

The roles of mutated SWI/SNF complexes in the initiation and development of hepatocellular carcinoma and its regulatory effect on the immune system: A review

Cell Proliferation, Volume 53, Issue 4, April 2020., 2020
Abstract Hepatocellular carcinoma (HCC) is a primary liver malignancy with a high global prevalence and a dismal prognosis. Studies are urgently needed to examine the molecular pathogenesis and biological characteristics of HCC. Chromatin remodelling, an integral component of the DNA damage response, protects against DNA damage‐induced genome ...
Bo Hu, Jian‐Zhen Lin, Xiao‐Bo Yang, Xin‐Ting Sang   +3 more
wiley   +1 more source