Results 11 to 20 of about 5,717 (90)

Effect of targeted regulation of phosphatase and tensin homolog and phosphatidylinositol 3-kinase on the proliferation and apoptosis of nephroblastoma cells [PDF]

精准医学杂志
Objective To investigate the effect and mechanism of targeted regulation of phosphatase and tensin homolog (PTEN) and phosphatidylinositol 3-kinase (PI3K) on the proliferation and apoptosis of nephroblastoma cells. Methods Posto-perative tumor tissue and
GENG Geng, LU Hongting, LI Qinghao, MING Ming
doaj   +1 more source

Concurrent Down-Regulation of PTEN and NKX3.1 Expression in Iranian Patients with Prostate Cancer

International Brazilian Journal of Urology, 2015
NKX3.1 and PTEN genes are involved in the development and progression of prostate cancer (PCa). Here, in line with other studies that correlated the expression of these two genes, we aimed at evaluating the expression pattern of these genes in clinical ...
Vahideh Nodouzi, Mohammadreza Nowroozi, Mehrdad Hashemi, Gholareza Javadi, Reza Mahdian   +4 more
doaj   +1 more source

Effect of minocycline on cognitive dysfunction in mice with intracerebral hemorrhage and its mechanism [PDF]

精准医学杂志
Objective To investigate the effect of minocycline (Mcy) on cognitive dysfunction in mice with intracerebral hemorrhage (ICH) and its mechanism. Methods Male C57BL/6J mice were randomly divided into groups A, B, C, D, and E, with 20 mice in each group ...
LI Yangyang, FANG Jian, WANG Xiaoxue
doaj   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Enzymes

British Journal of Pharmacology, Volume 176, Issue S1, Page S297-S396, December 2019., 2019
The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www ...
Stephen P H Alexander, Doriano Fabbro, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies, CGTP Collaborators, Annie Beuve, Detlev Boison, Peter Brouckaert, John C Burnett, Kathryn Burns, Carmen Dessauer, Andreas Friebe, John Garthwaite, Jürg Gertsch, Nuala Helsby, Angelo A Izzo, Doris Koesling, Michaela Kuhn, Rennolds Ostrom, Andreas Papapetropoulos, Lincoln R Potter, Nigel J Pyne, Susan Pyne, Michael Russwurm, Harald HHW Schmidt, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts   +39 more
wiley   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Enzymes

British Journal of Pharmacology, Volume 174, Issue S1, Page S272-S359, December 2017., 2017
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand ...
Stephen PH Alexander, Doriano Fabbro, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies, CGTP Collaborators   +11 more
wiley   +1 more source

Beyond Immune Cell Migration: The Emerging Role of the Sphingosine‐1‐phosphate Receptor S1PR4 as a Modulator of Innate Immune Cell Activation

Mediators of Inflammation, Volume 2017, Issue 1, 2017., 2017
The sphingolipid sphingosine‐1‐phosphate (S1P) emerges as an important regulator of immunity, mainly by signaling through a family of five specific G protein‐coupled receptors (S1PR1–5). While S1P signaling generally has the potential to affect not only trafficking but also differentiation, activation, and survival of a diverse range of immune cells ...
Catherine Olesch, Christian Ringel, Bernhard Brüne, Andreas Weigert, Alice Alessenko   +4 more
wiley   +1 more source

Herbal Medicines for the Treatment of Nonalcoholic Steatohepatitis: Current Scenario and Future Prospects

Evidence-Based Complementary and Alternative Medicine, Volume 2014, Issue 1, 2014., 2014
Nonalcoholic steatohepatitis (NASH) is a multifactorial disease and has close correlations with other metabolic disorders. This makes its treatment difficult using a single pharmacological drug. Use of plant extract/decoction or polyherbal formulation to treat various liver diseases is very well mentioned in various traditional systems of medicine ...
Ravirajsinh Jadeja, Ranjitsinh V. Devkar, Srinivas Nammi, Menaka C. Thounaojam   +3 more
wiley   +1 more source

Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia

, 2011
The MYC oncogenic transcription factor is overexpressed in most human cases of T cell acute lymphoblastic leukemia (T-ALL), often downstream of mutational NOTCH1 activation. Genetic alterations in the PTEN-PI3K-AKT pathway are also common in T-ALL.
Harris, M., Gutierrez, A., Testa, J.R., Payne, E., Prochownik, E.V., Grebliunaite, R., Look, A. T., Neuberg, D. S., Dahlberg, S.E., den Hertog, J., Mansour, M., Prochownik, E. V., Dahlberg, S. E., Neuberg, D.S., Feng, H., Kanki, J.P., Guo, F., Look, A.T., Zhu, S., Testa, J. R., Hertog den, J., Kozakewich, E., Kanki, J. P.   +22 more
core   +1 more source

Análise do gene PTEN por hibridização in situ fluorescente no carcinoma de células renais

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: avaliar a frequência de deleção do gene PTEN no carcinoma de células renais e o impacto da deleção nas taxas de sobrevida global e livre de doença.
Eurico Cleto Ribeiro de Campos, Francisco Paulo da Fonseca, Stênio de Cássio Zequ, Gustavo Cardoso Guimarães, Fernando Augusto Soares, Ademar Lopes   +5 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source