Results 21 to 30 of about 11,249 (206)
Bleeding, Thrombosis and Vascular Biology, 2023 The platelet collagen receptor glycoprotein VI (GPVI) signals to activation of phospholipase Cγ2 (PLCγ2) and phosphoinositide 3-kinases (PI3K), causing platelet activation and aggregation.
Jingnan Huang +5 more
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Cell Reports, 2021 Summary: Phosphoinositides are important molecules in lipid signaling, membrane identity, and trafficking that are spatiotemporally controlled by factors from both mammalian cells and intracellular pathogens.
Kai Liu +4 more
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Biomolecules, 2021 Protein tyrosine kinases and protein phosphatases play a critical role in cellular regulation. The length of a cellular response depends on the interplay between activating protein kinases and deactivating protein phosphatases.
Raju V. S. Rajala +4 more
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PI(3,4)P2 Signaling in Cancer and Metabolism
Frontiers in Oncology, 2020 The phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and mammalian target of rapamycin (mTOR) are central regulators of glycolysis, cancer metabolism, and cancer cell proliferation.
Luca Gozzelino +4 more
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Phosphoinositides in the kidney
Journal of Lipid Research, 2019 Phosphoinositides (PIs) play pivotal roles in the regulation of many biological processes. The quality and quantity of PIs is regulated in time and space by the activity of PI kinases and PI phosphatases. The number of PI-metabolizing enzymes exceeds the
Leopoldo Staiano +1 more
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Emerging roles of PHLPP phosphatases in lung cancer
Frontiers in Oncology, 2023 Pleckstrin homologous domain leucine-rich repeating protein phosphatases (PHLPPs) were originally identified as protein kinase B (Akt) kinase hydrophobic motif specific phosphatases to maintain the cellular homeostasis.
Xinhang Xia +7 more
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Assembly of a Fab1 Phosphoinositide Kinase Signaling Complex Requires the Fig4 Phosphoinositide Phosphatase [PDF]
Molecular Biology of the Cell, 2008 Phosphatidylinositol-3,5-bisphosphate [PtdIns(3,5)P 2 ] regulates several vacuolar functions, including acidification, morphology, and membrane traffic. The lipid kinase Fab1 converts phosphatidylinositol-3-phosphate [PtdIns(3)P] to PtdIns(3,5)P 2 ...
Roberto J, Botelho +3 more
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A direct fluorometric activity assay for lipid kinases and phosphatases
Journal of Lipid Research, 2020 Lipid kinases and phosphatases play key roles in cell signaling and regulation, are implicated in many human diseases, and are thus attractive targets for drug development.
Jiachen Sun +3 more
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Identification and Structural Characterization of a Legionella Phosphoinositide Phosphatase* [PDF]
Journal of Biological Chemistry, 2013 Bacterial pathogen Legionella pneumophila is the causative agent of Legionnaires' disease, which is associated with intracellular replication of the bacteria in macrophages of human innate immune system. Recent studies indicate that pathogenic bacteria can subvert host cell phosphoinositide (PI) metabolism by translocated virulence effectors.
Leila, Toulabi +3 more
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FEBS Open Bio, 2020 Phosphatidylinositol (3,4,5)‐trisphosphate (PI(3,4,5)P3) is required for protein kinase B (AKT) activation. The level of PI(3,4,5)P3 is constantly regulated through balanced synthesis by phosphoinositide 3‐kinase (PI3K) and degradation by ...
Abdelhalim Azzi
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