Results 1 to 10 of about 72,943 (293)
Virulence, 2021 PE_PGRS proteins of Mycobacterium tuberculosis (Mtb) constitute a large family of complex modular proteins whose role is still unclear. Among those, we have previously shown, using the heterologous expression in Mycobacterium smegmatis, that PE_PGRS3 ...
Flavio De Maio +2 more
exaly +3 more sources
Lipid Subclasses Differentiate Insulin Resistance by Triglyceride–Glucose Index [PDF]
MetabolitesBackground: Insulin resistance is a key driver of metabolic syndrome and related disorders, yet its underlying metabolic alterations remain incompletely understood.
Khaled Naja +3 more
doaj +2 more sources
Untargeted lipidomics analysis in women with morbid obesity and type 2 diabetes mellitus: A comprehensive study. [PDF]
PLoS ONEThere is a phenotype of obese individuals termed metabolically healthy obese that present a reduced cardiometabolic risk. This phenotype offers a valuable model for investigating the mechanisms connecting obesity and metabolic alterations such as Type 2 ...
Laia Bertran +5 more
doaj +2 more sources
Branched-chain amino acids and specific phosphatidylinositols are plasma metabolite pairs associated with menstrual pain severity [PDF]
Scientific ReportsMenstrual pain affects women’s quality of life and productivity, yet objective molecular markers for its severity have not been established owing to the variability in blood levels and chemical properties of potential markers such as plasma steroid ...
Atsushi Sato +4 more
doaj +2 more sources
Biomolecules, 2023 Myo-inositol belongs to one of the sugar alcohol groups known as cyclitols. Phosphatidylinositols are one of the derivatives of Myo-inositol, and constitute important mediators in many intracellular processes such as cell growth, cell differentiation ...
Maria Derkaczew +5 more
doaj +1 more source
Identification of Key Phospholipids That Bind and Activate Atypical PKCs
Biomedicines, 2021 PKCζ and PKCι/λ form the atypical protein kinase C subgroup, characterised by a lack of regulation by calcium and the neutral lipid diacylglycerol. To better understand the regulation of these kinases, we systematically explored their interactions with ...
Suresh Velnati +10 more
doaj +1 more source
BIOSYNTHESIS OF PHOSPHATIDYLINOSITOL [PDF]
Annals of the New York Academy of Sciences, 1970 Interest in our laboratory in the inositol lipids derives from the presence of relatively high amounts of phosphatidylinositol phosphate (PhIP) and phosphatidylinositol diphosphate (PhIPP) in excitable tissue. It was with this relationship in mind that we embarked on a study of biosynthetic pathways of inositol lipids several years ago. A first step in
Agranoff, Bernard W. +2 more
openaire +3 more sources
Oleic Acid-Containing Phosphatidylinositol Is a Blood Biomarker Candidate for SPG28
Biomedicines, 2023 Hereditary spastic paraplegia is a genetic neurological disorder characterized by spasticity of the lower limbs, and spastic paraplegia type 28 is one of its subtypes.
Takuya Morikawa +8 more
doaj +1 more source
Regulation of Necroptosis by Phospholipids and Sphingolipids
Cells, 2020 Several non-apoptotic regulated cell death pathways have been recently reported. Necroptosis, a form of necrotic-regulated cell death, is characterized by the involvement of receptor-interacting protein kinases and/or the pore-forming mixed lineage ...
Xuewei Zhang +4 more
doaj +1 more source
Discovery of the inhibitory effect of a phosphatidylinositol derivative on P-glycoprotein by virtual screening followed by in vitro cellular studies. [PDF]
PLoS ONE, 2013 P-glycoprotein is capable of effluxing a broad range of cytosolic and membrane penetrating xenobiotic substrates, thus leading to multi-drug resistance and posing a threat for the therapeutic treatment of several diseases, including cancer and central ...
Xavier Lucas +3 more
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