Results 31 to 40 of about 72,943 (293)
International Journal of Biochemistry and Cell Biology, 2012 Crohn's disease is a chronic inflammatory condition largely affecting the terminal ileum and large bowel. A contributing cause is the failure of an adequate acute inflammatory response as a result of impaired secretion of pro-inflammatory cytokines by ...
G. Sewell +12 more
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Cancer Research, 2009 The NF2 tumor suppressor gene encodes an intracellular membrane-associated protein, called merlin, which belongs to the band 4.1 family of cytoskeleton-associated proteins that link cell surface glycoproteins to actin cytoskeleton. Merlin suppresses PI 3-
M. Okada +5 more
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Tamoxifen inhibits the biosynthesis of inositolphosphorylceramide in Leishmania
International Journal for Parasitology: Drugs and Drug Resistance, 2018 Previous work from our group showed that tamoxifen, an oral drug that has been in use for the treatment of breast cancer for over 40 years, is active both in vitro and in vivo against several species of Leishmania, the etiological agent of leishmaniasis.
Cristiana T. Trinconi +7 more
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Mammalian Phosphatidylinositol 4‐Kinases [PDF]
IUBMB Life, 2003 AbstractThree phosphatidylinositol 4‐kinase isoforms, PI4K 230, 92 and 55 have been cloned and sequenced allowing a much wider characterization than the previously employed enzymological typing into type II and III enzymes. PI4K 230 and 92 contain a highly conserved catalytic core, PI4K55 one with a much lower degree of similarity.
Ludwig M G, Heilmeyer +4 more
openaire +2 more sources
Foods, 2022 Rosa roxburghii fruit is an underutilized functional food abundant in polyphenols. Polyphenols have been proved to have antidiabetic effects. This study investigates the effects of Rosa roxburghii fruit polyphenols extract (RPE) on plasma metabolites and
Hui Wang +8 more
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Journal of Biological Chemistry, 1991 In addition to utilizing glycosylated phosphatidylinositols (GPIs) as anchors for surface proteins, protozoan parasites of the genus Leishmania synthesize two novel classes of GPI: the polydisperse lipophosphoglycans (LPGs) and a family of low molecular ...
Malcolm J. McConville +1 more
semanticscholar +1 more source
Biomédica: revista del Instituto Nacional de Salud, 2015 Introducción. La leishmaniasis es una enfermedad de gran impacto en la salud pública. La Organización Mundial de la Salud considera prioritaria la investigación orientada al desarrollo de medicamentos para su tratamiento.
Valeria Velásquez +2 more
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EHD1 and Eps15 Interact with Phosphatidylinositols via Their Eps15 Homology Domains*
Journal of Biological Chemistry, 2007 The C-terminal Eps15 homology domain-containing protein, EHD1, regulates the recycling of receptors from the endocytic recycling compartment to the plasma membrane. In cells, EHD1 localizes to tubular and spherical recycling endosomes.
Naava Naslavsky +4 more
semanticscholar +1 more source
Glycophosphosphingolipid (GSPL) Purification Protocol
Bio-Protocol, 2012 Glycosylated ceramide phosphorylinositol are present in many species of fungi and mushrooms and bacteria and parasitic organisms like leishmania. These are usually membrane raft associated and are not easily extracted by conventional methodologies.
Tripti De
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Redox Biology, 2020 Phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3] is a phosphorylated derivative of phosphatidylinositol 4-phosphate [PI(4)P] and phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], which recruit and activate AKT in the plasma membrane (PM) to ...
Fei-Fei Shang +9 more
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