Results 31 to 40 of about 930 (239)

Tamoxifen inhibits the biosynthesis of inositolphosphorylceramide in Leishmania

International Journal for Parasitology: Drugs and Drug Resistance, 2018
Previous work from our group showed that tamoxifen, an oral drug that has been in use for the treatment of breast cancer for over 40 years, is active both in vitro and in vivo against several species of Leishmania, the etiological agent of leishmaniasis.
Cristiana T. Trinconi, Danilo C. Miguel, Ariel M. Silber, Christopher Brown, John G.M. Mina, Paul W. Denny, Norton Heise, Silvia R.B. Uliana   +7 more
doaj   +1 more source

Optimization of chromatographic buffer conditions for the simultaneous analysis of phosphatidylinositol and phosphatidylinositol phosphate species in canola [PDF]

, 2023
The phosphatidylinositols and phosphatidylinositol phosphates are a set of closely related lipids known to influence various cellular functions. Irregular distributions of these molecules have been correlated with the development and progression of ...
Gertner, DS, Bishop, DP, David P Bishop, Matthew P Padula, Padula, MP, David S Gertner   +5 more
core   +1 more source

Detección de blancos moleculares en la ruta de señalización del fosfatidil-inositol en Leishmania spp. mediante herramientas bioinformáticas y de modelado matemático

Biomédica: revista del Instituto Nacional de Salud, 2015
Introducción. La leishmaniasis es una enfermedad de gran impacto en la salud pública. La Organización Mundial de la Salud considera prioritaria la investigación orientada al desarrollo de medicamentos para su tratamiento.
Valeria Velásquez, Rodrigo Ochoa, Carlos Muskus   +2 more
doaj   +1 more source

The Effect of Polyphenol Extract from Rosa Roxburghii Fruit on Plasma Metabolome and Gut Microbiota in Type 2 Diabetic Mice

Foods, 2022
Rosa roxburghii fruit is an underutilized functional food abundant in polyphenols. Polyphenols have been proved to have antidiabetic effects. This study investigates the effects of Rosa roxburghii fruit polyphenols extract (RPE) on plasma metabolites and
Hui Wang, Zhaojun Chen, Mei Wang, Mingxiu Long, Tingyuan Ren, Chao Chen, Xiaotong Dai, Sheng Yang, Shuming Tan   +8 more
doaj   +1 more source

Mammalian Phosphatidylinositol 4‐Kinases [PDF]

IUBMB Life, 2003
AbstractThree phosphatidylinositol 4‐kinase isoforms, PI4K 230, 92 and 55 have been cloned and sequenced allowing a much wider characterization than the previously employed enzymological typing into type II and III enzymes. PI4K 230 and 92 contain a highly conserved catalytic core, PI4K55 one with a much lower degree of similarity.
Ludwig M G, Heilmeyer, György, Vereb, György, Vereb, Annamária, Kakuk, Ilona, Szivák   +4 more
openaire   +2 more sources

Glycophosphosphingolipid (GSPL) Purification Protocol

Bio-Protocol, 2012
Glycosylated ceramide phosphorylinositol are present in many species of fungi and mushrooms and bacteria and parasitic organisms like leishmania. These are usually membrane raft associated and are not easily extracted by conventional methodologies.
Tripti De
doaj   +1 more source

CircRNA_0001449 disturbs phosphatidylinositol homeostasis and AKT activity by enhancing Osbpl5 translation in transient cerebral ischemia

Redox Biology, 2020
Phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3] is a phosphorylated derivative of phosphatidylinositol 4-phosphate [PI(4)P] and phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], which recruit and activate AKT in the plasma membrane (PM) to ...
Fei-Fei Shang, Li Luo, Jianghong Yan, Qiubo Yu, Yongzheng Guo, Yuchen Wen, Xiao-Li Min, Ling Jiang, Xiang He, Wei Liu   +9 more
doaj   +1 more source

Cholestasis alters brain lipid and bile acid composition and compromises motor function in neonatal piglets

Physiological Reports, 2022
Infants with neonatal cholestasis are prone to neurodevelopmental deficits, however, the underlying pathogenesis is unclear. Lipid malabsorption and accumulation of potentially neurotoxic molecules in the blood such as bile acids are important yet ...
Nicole Lind Henriksen, Svend Høime Hansen, Matthew Domenic Lycas, Xiaoyu Pan, Thomas Eriksen, Lars Søndergaard Johansen, Richard R. Sprenger, Christer Stenby Ejsing, Douglas G. Burrin, Kerstin Skovgaard, Vibeke Brix Christensen, Thomas Thymann, Stanislava Pankratova   +12 more
doaj   +1 more source

Biological characteristics of SARS-CoV-2 resistant populations by integrated gut microbiota sequencing, metabolomics, and proteomics: a cohort comparison study

Frontiers in Medicine
ObjectiveMost research reports on COVID-19 infections have focused on the correlation between the severity of the disease symptoms and immune deficits, while the mechanisms affecting the susceptibility to SARS-CoV-2 remain largely unknown.
Huachong Xu, Haoxuan Li, Junhao Xu, Yaoxin Chen, Li Deng, Xiaoyin Chen, Yinji Xu, Yinji Xu   +7 more
doaj   +1 more source

Exogenous melatonin enhances the growth and production of bioactive metabolites in Lemna aequinoctialis culture by modulating metabolic and lipidomic profiles

BMC Plant Biology, 2022
Background Lemna species are cosmopolitan floating plants that have great application potential in the food/feed, pharmaceutical, phytoremediation, biofuel, and bioplastic industries.
GahYoung Baek, Hwanhui Lee, JuHee Ko, Hyung-Kyoon Choi   +3 more
doaj   +1 more source