Results 31 to 40 of about 73,691 (318)

High-resolution imaging mass spectrometry combined with transcriptomic analysis identified a link between fatty acid composition of phosphatidylinositols and the immune checkpoint pathway at the primary tumour site of breast cancer

British Journal of Cancer, 2019
Background The fatty acid (FA) composition of phosphatidylinositols (PIs) is tightly regulated in mammalian tissue since its disruption impairs normal cellular functions.
M. Kawashima, M. Tokiwa, T. Nishimura, Yukiko Kawata, M. Sugimoto, T. Kataoka, T. Sakurai, K. Iwaisako, E. Suzuki, M. Hagiwara, A. Harris, M. Toi   +11 more
semanticscholar   +1 more source

Rebaudioside A Enhances Resistance to Oxidative Stress and Extends Lifespan and Healthspan in Caenorhabditis elegans

Antioxidants, 2021
Non-nutritive sweeteners are widely used in food and medicines to reduce energy content without compromising flavor. Herein, we report that Rebaudioside A (Reb A), a natural, non-nutritive sweetener, can extend both the lifespan and healthspan of C ...
Pan Li, Zehua Wang, Sin Man Lam, Guanghou Shui   +3 more
doaj   +1 more source

Differential distribution of orthophosphate-32P and glycerol-14C among molecular species of phosphatidylinositols of rat liver in vivo

Journal of Lipid Research, 1971
The incorporation of orthophosphate-32P and glycerol-2-14C into the various species of rat liver phosphatidylinositols as a function of time was determined in vivo. 32P was administered intraperitoneally and glycerol-14C was given intravenously.
B.J. HOLUB, A. KUKSIS
doaj   +1 more source

T cells transduce T-cell receptor signal strength by generating different phosphatidylinositols

Journal of Biological Chemistry, 2019
T-cell receptor (TCR) signaling strength is a dominant factor regulating T-cell differentiation, thymic development, and cytokine signaling. The molecular mechanisms by which TCR signal strength is transduced to downstream signaling networks remains ill ...
W. Hawse, R. Cattley
semanticscholar   +1 more source

Enhancing the Characterisation of the Phosphatidylinositols [PDF]

, 2023
University of Technology Sydney. Faculty of Science.The phosphatidylinositols are an interesting and diverse group of molecules. They’re ubiquitous throughout known life and are involved in almost every aspect of a cell's life and death.
Gertner, David
core  

SAC1 degrades its lipid substrate PtdIns4P in the endoplasmic reticulum to maintain a steep chemical gradient with donor membranes

eLife, 2018
Gradients of PtdIns4P between organelle membranes and the endoplasmic reticulum (ER) are thought to drive counter-transport of other lipids via non-vesicular traffic.
James P Zewe, Rachel C Wills, Sahana Sangappa, Brady D Goulden, Gerald RV Hammond   +4 more
doaj   +1 more source

Phosphatidylinositol(4,5)bisphosphate and Phosphatidylinositol(4)phosphate in Plant Tissues [PDF]

Plant Physiology, 1989
Pea (Pisum sativum) leaf discs or swimming suspensions of Chlamydomonas eugametos were radiolabeled with [(3)H]myo-inositol or [(32)P]Pi and the lipids were extracted, deacylated, and their glycerol moieties removed. The resulting inositol trisphosphate and bisphosphate fractions were examined by periodate degradation, reduction and dephosphorylation ...
R F, Irvine, A J, Letcher, D J, Lander, B K, Drøbak, A P, Dawson, A, Musgrave   +5 more
openaire   +2 more sources

Intact Cell Lipidomics Reveal Changes to the Ratio of Cardiolipins to Phosphatidylinositols in Response to Kanamycin in HeLa and Primary Cells. [PDF]

, 2018
Antimicrobial resistance is a major threat the world is currently facing. Development of new antibiotics and the assessment of their toxicity represent important challenges.
Thomson, Michael, Michael Thomson, Ivana Pennisi (5498120), Larrouy-Maumus, GJ, Serge Mostowy, Mostowy, Serge, Damian Lobato-Márquez (5498117), Sonia Rebollo-Ramirez, Gerald Larrouy-Maumus (4395031), Ivana Pennisi, Lobato-Márquez, Damian, Sonia Rebollo-Ramirez (4395025), Michael Thomson (376401), Sina Krokowski, Larrouy-Maumus, Gerald, Krokowski, Sina, Damian Lobato-Márquez, Gerald Larrouy-Maumus, Pennisi, Ivana, Rebollo-Ramirez, Sonia, Sina Krokowski (5498123), Serge Mostowy (211097)   +21 more
core   +1 more source

Lipid Polarization during Cytokinesis

Cells, 2022
The plasma membrane of eukaryotic cells is composed of a large number of lipid species that are laterally segregated into functional domains as well as asymmetrically distributed between the outer and inner leaflets.
Govind Kunduri, Usha Acharya, Jairaj K. Acharya   +2 more
doaj   +1 more source

Optimization of chromatographic buffer conditions for the simultaneous analysis of phosphatidylinositol and phosphatidylinositol phosphate species in canola [PDF]

, 2023
The phosphatidylinositols and phosphatidylinositol phosphates are a set of closely related lipids known to influence various cellular functions. Irregular distributions of these molecules have been correlated with the development and progression of ...
Gertner, DS, Bishop, DP, David P Bishop, Matthew P Padula, Padula, MP, David S Gertner   +5 more
core   +2 more sources