Results 11 to 20 of about 930 (239)
Discovery of the inhibitory effect of a phosphatidylinositol derivative on P-glycoprotein by virtual screening followed by in vitro cellular studies. [PDF]
PLoS ONE, 2013 P-glycoprotein is capable of effluxing a broad range of cytosolic and membrane penetrating xenobiotic substrates, thus leading to multi-drug resistance and posing a threat for the therapeutic treatment of several diseases, including cancer and central ...
Xavier Lucas +3 more
doaj +1 more source
Scientific Reports, 2021 Lipidome-wide metabolites may be useful biomarkers of pregnancy outcomes. We sought to characterize maternal lipidomic signatures associated with preterm birth and neonatal anthropometric parameters.
Max T. Aung +8 more
doaj +1 more source
List of putatively identified phosphatidylinositols from S. cf. horrens.
, 2023 List of putatively identified phosphatidylinositols from S. cf. horrens.
Ralph John Emerson J. Molino (10833305) +3 more
core +1 more source
Cell Communication and Signaling, 2021 Alzheimer’s disease is one of the neurodegenerative diseases, characterized by the accumulation of abnormal protein deposits, which disrupts signal transduction in neurons and other glia cells.
Smita Eknath Desale +1 more
doaj +1 more source
Worms, Fat, and Death: Caenorhabditis elegans Lipid Metabolites Regulate Cell Death
Metabolites, 2021 Caenorhabditis elegans is well-known as the model organism used to elucidate the genetic pathways underlying the first described form of regulated cell death, apoptosis. Since then, C.
Marcos A. Perez, Jennifer L. Watts
doaj +1 more source
Phosphatidylinositol 4-kinases [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1998 Polyphosphoinositides are involved in many signal transduction pathways in eukaryotic cells. The first committed step is catalysed by phosphatidylinositol 4‐kinase leading to the formation of phosphatidylinositol 4‐phosphate. In the last four years, ten cDNA molecules have been cloned which code isoforms of phosphatidylinositol 4‐kinase; some of which ...
T, Gehrmann, L M, Heilmeyer
openaire +4 more sources
Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis
eLife, 2017 Phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] is essential for exocytosis. Classical ways of manipulating PI(4,5)P2 levels are slower than its metabolism, making it difficult to distinguish effects of PI(4,5)P2 from those of its metabolites.
Alexander M Walter +15 more
doaj +1 more source
The ether lipid precursor hexadecylglycerol causes major changes in the lipidome of HEp-2 cells. [PDF]
PLoS ONE, 2013 The ether-lipid precursor sn-1-O-hexadecylglycerol (HG) can be used to compensate for early metabolic defects in ether-lipid biosynthesis. To investigate a possible metabolic link between ether-linked phospholipids and the rest of the cellular lipidome ...
Jonas Bergan +5 more
doaj +1 more source
Function of Phosphatidylinositol in Mycobacteria [PDF]
Journal of Biological Chemistry, 2005 Phosphatidylinositol (PI) is an abundant phospholipid in the cytoplasmic membrane of mycobacteria and the precursor for more complex glycolipids, such as the PI mannosides (PIMs) and lipoarabinomannan (LAM). To investigate whether the large steady-state pools of PI and apolar PIMs are required for mycobacterial growth, we have generated a Mycobacterium
Ruth E, Haites +3 more
openaire +2 more sources