The Genetic Background of Abnormalities in Metabolic Pathways of Phosphoinositides and Their Linkage with the Myotubular Myopathies, Neurodegenerative Disorders, and Carcinogenesis [PDF]
Biomolecules, 2023 Myo-inositol belongs to one of the sugar alcohol groups known as cyclitols. Phosphatidylinositols are one of the derivatives of Myo-inositol, and constitute important mediators in many intracellular processes such as cell growth, cell differentiation ...
Maria Derkaczew +5 more
doaj +2 more sources
Akt Phosphorylation of Merlin Enhances its Binding to Phosphatidylinositols and Inhibits Tumor Suppressive Activities of Merlin [PDF]
Cancer Research, 2009 The NF2 tumor suppressor gene encodes an intracellular membrane-associated protein, called merlin, which belongs to the band 4.1 family of cytoskeleton-associated proteins that link cell surface glycoproteins to actin cytoskeleton. Merlin suppresses PI 3-
M. Okada +5 more
semanticscholar +2 more sources
Oleic Acid-Containing Phosphatidylinositol Is a Blood Biomarker Candidate for SPG28 [PDF]
Biomedicines, 2023 Hereditary spastic paraplegia is a genetic neurological disorder characterized by spasticity of the lower limbs, and spastic paraplegia type 28 is one of its subtypes.
Takuya Morikawa +8 more
doaj +2 more sources
Identification of mitogen-activated protein kinase docking sites in enzymes that metabolize phosphatidylinositols and inositol phosphates [PDF]
Cell Communication and Signaling, 2006 Background Reversible interactions between the components of cellular signaling pathways allow for the formation and dissociation of multimolecular complexes with spatial and temporal resolution and, thus, are an important means of integrating multiple ...
Buckley Colin T +2 more
doaj +2 more sources
Discovery of the inhibitory effect of a phosphatidylinositol derivative on P-glycoprotein by virtual screening followed by in vitro cellular studies. [PDF]
PLoS ONE, 2013 P-glycoprotein is capable of effluxing a broad range of cytosolic and membrane penetrating xenobiotic substrates, thus leading to multi-drug resistance and posing a threat for the therapeutic treatment of several diseases, including cancer and central ...
Xavier Lucas +3 more
doaj +4 more sources
Comprehensive and Uniform Synthesis of All Naturally Occurring Phosphorylated Phosphatidylinositols [PDF]
, 2016 Studies of cellular signal transduction mechanisms involving receptor-mediated generation of inositol phosphates and phosphorylated phosphatidylinositols require easy access to these naturally occurring products.
Karol S. Bruzik (2060551) +1 more
core +5 more sources
Phosphorylation of phosphatidylinositols in isolated plant membranes
FEBS Letters, 1986 A. Sandelius, M. Sommarin
exaly +2 more sources
List of putatively identified phosphatidylinositols from S. cf. horrens. [PDF]
, 2023 List of putatively identified phosphatidylinositols from S. cf. horrens.
Ralph John Emerson J. Molino (10833305) +3 more
core +1 more source
Identification of Key Phospholipids That Bind and Activate Atypical PKCs
Biomedicines, 2021 PKCζ and PKCι/λ form the atypical protein kinase C subgroup, characterised by a lack of regulation by calcium and the neutral lipid diacylglycerol. To better understand the regulation of these kinases, we systematically explored their interactions with ...
Suresh Velnati +10 more
doaj +1 more source
BIOSYNTHESIS OF PHOSPHATIDYLINOSITOL [PDF]
Annals of the New York Academy of Sciences, 1970 Interest in our laboratory in the inositol lipids derives from the presence of relatively high amounts of phosphatidylinositol phosphate (PhIP) and phosphatidylinositol diphosphate (PhIPP) in excitable tissue. It was with this relationship in mind that we embarked on a study of biosynthetic pathways of inositol lipids several years ago. A first step in
Agranoff, Bernard W. +2 more
openaire +3 more sources