Results 21 to 30 of about 72,943 (293)

The ether lipid precursor hexadecylglycerol causes major changes in the lipidome of HEp-2 cells. [PDF]

PLoS ONE, 2013
The ether-lipid precursor sn-1-O-hexadecylglycerol (HG) can be used to compensate for early metabolic defects in ether-lipid biosynthesis. To investigate a possible metabolic link between ether-linked phospholipids and the rest of the cellular lipidome ...
Jonas Bergan, Tore Skotland, Tuulia Sylvänne, Helena Simolin, Kim Ekroos, Kirsten Sandvig   +5 more
doaj   +1 more source

Function of Phosphatidylinositol in Mycobacteria [PDF]

Journal of Biological Chemistry, 2005
Phosphatidylinositol (PI) is an abundant phospholipid in the cytoplasmic membrane of mycobacteria and the precursor for more complex glycolipids, such as the PI mannosides (PIMs) and lipoarabinomannan (LAM). To investigate whether the large steady-state pools of PI and apolar PIMs are required for mycobacterial growth, we have generated a Mycobacterium
Ruth E, Haites, Yasu S, Morita, Malcolm J, McConville, Helen, Billman-Jacobe   +3 more
openaire   +2 more sources

Ion Mobility–Mass Spectrometry Approach for the Comparison of Sheep and Goat Milk Lipidomes

Applied Sciences, 2023
In this work, we report an analytical procedure to investigate the lipid compositions of sheep and goat milk. This approach is based on an ion mobility–high-resolution mass spectrometric method to facilitate the identification of complex lipid species ...
Cristina Manis, Paola Scano, Viviana Garau, Margherita Addis, Ignazio Ibba, Pierluigi Caboni   +5 more
doaj   +1 more source

High-resolution imaging mass spectrometry combined with transcriptomic analysis identified a link between fatty acid composition of phosphatidylinositols and the immune checkpoint pathway at the primary tumour site of breast cancer

British Journal of Cancer, 2019
Background The fatty acid (FA) composition of phosphatidylinositols (PIs) is tightly regulated in mammalian tissue since its disruption impairs normal cellular functions.
M. Kawashima, M. Tokiwa, T. Nishimura, Yukiko Kawata, M. Sugimoto, T. Kataoka, T. Sakurai, K. Iwaisako, E. Suzuki, M. Hagiwara, A. Harris, M. Toi   +11 more
semanticscholar   +1 more source

Differential distribution of orthophosphate-32P and glycerol-14C among molecular species of phosphatidylinositols of rat liver in vivo

Journal of Lipid Research, 1971
The incorporation of orthophosphate-32P and glycerol-2-14C into the various species of rat liver phosphatidylinositols as a function of time was determined in vivo. 32P was administered intraperitoneally and glycerol-14C was given intravenously.
B.J. HOLUB, A. KUKSIS
doaj   +1 more source

Rebaudioside A Enhances Resistance to Oxidative Stress and Extends Lifespan and Healthspan in Caenorhabditis elegans

Antioxidants, 2021
Non-nutritive sweeteners are widely used in food and medicines to reduce energy content without compromising flavor. Herein, we report that Rebaudioside A (Reb A), a natural, non-nutritive sweetener, can extend both the lifespan and healthspan of C ...
Pan Li, Zehua Wang, Sin Man Lam, Guanghou Shui   +3 more
doaj   +1 more source

T cells transduce T-cell receptor signal strength by generating different phosphatidylinositols

Journal of Biological Chemistry, 2019
T-cell receptor (TCR) signaling strength is a dominant factor regulating T-cell differentiation, thymic development, and cytokine signaling. The molecular mechanisms by which TCR signal strength is transduced to downstream signaling networks remains ill ...
W. Hawse, R. Cattley
semanticscholar   +1 more source

SAC1 degrades its lipid substrate PtdIns4P in the endoplasmic reticulum to maintain a steep chemical gradient with donor membranes

eLife, 2018
Gradients of PtdIns4P between organelle membranes and the endoplasmic reticulum (ER) are thought to drive counter-transport of other lipids via non-vesicular traffic.
James P Zewe, Rachel C Wills, Sahana Sangappa, Brady D Goulden, Gerald RV Hammond   +4 more
doaj   +1 more source

Phosphatidylinositol(4,5)bisphosphate and Phosphatidylinositol(4)phosphate in Plant Tissues [PDF]

Plant Physiology, 1989
Pea (Pisum sativum) leaf discs or swimming suspensions of Chlamydomonas eugametos were radiolabeled with [(3)H]myo-inositol or [(32)P]Pi and the lipids were extracted, deacylated, and their glycerol moieties removed. The resulting inositol trisphosphate and bisphosphate fractions were examined by periodate degradation, reduction and dephosphorylation ...
R F, Irvine, A J, Letcher, D J, Lander, B K, Drøbak, A P, Dawson, A, Musgrave   +5 more
openaire   +2 more sources

Lipid Polarization during Cytokinesis

Cells, 2022
The plasma membrane of eukaryotic cells is composed of a large number of lipid species that are laterally segregated into functional domains as well as asymmetrically distributed between the outer and inner leaflets.
Govind Kunduri, Usha Acharya, Jairaj K. Acharya   +2 more
doaj   +1 more source