Results 51 to 60 of about 73,691 (318)

Cholestasis alters brain lipid and bile acid composition and compromises motor function in neonatal piglets

Physiological Reports, 2022
Infants with neonatal cholestasis are prone to neurodevelopmental deficits, however, the underlying pathogenesis is unclear. Lipid malabsorption and accumulation of potentially neurotoxic molecules in the blood such as bile acids are important yet ...
Nicole Lind Henriksen, Svend Høime Hansen, Matthew Domenic Lycas, Xiaoyu Pan, Thomas Eriksen, Lars Søndergaard Johansen, Richard R. Sprenger, Christer Stenby Ejsing, Douglas G. Burrin, Kerstin Skovgaard, Vibeke Brix Christensen, Thomas Thymann, Stanislava Pankratova   +12 more
doaj   +1 more source

Molecular structure of the "low molecular weight antigen" of Toxoplasma gondii: a glucose alpha 1-4 N-acetylgalactosamine makes free glycosyl-phosphatidylinositols highly immunogenic.

Journal of Molecular Biology, 1997
Toxoplasma gondii is a ubiquitous parasitic protozoan causing congenital infection and severe encephalitis in the course of the acquired immunodeficiency syndrome. Glycosyl-phosphatidylinositols of T.
B. Striepen, C. Zinecker, J. B. Damm, P. A. Melgers, G. Gerwig, M. Koolen, J. Vliegenthart, J. Dubremetz, R. Schwarz   +8 more
semanticscholar   +1 more source

Biological characteristics of SARS-CoV-2 resistant populations by integrated gut microbiota sequencing, metabolomics, and proteomics: a cohort comparison study

Frontiers in Medicine
ObjectiveMost research reports on COVID-19 infections have focused on the correlation between the severity of the disease symptoms and immune deficits, while the mechanisms affecting the susceptibility to SARS-CoV-2 remain largely unknown.
Huachong Xu, Haoxuan Li, Junhao Xu, Yaoxin Chen, Li Deng, Xiaoyin Chen, Yinji Xu, Yinji Xu   +7 more
doaj   +1 more source

Exogenous melatonin enhances the growth and production of bioactive metabolites in Lemna aequinoctialis culture by modulating metabolic and lipidomic profiles

BMC Plant Biology, 2022
Background Lemna species are cosmopolitan floating plants that have great application potential in the food/feed, pharmaceutical, phytoremediation, biofuel, and bioplastic industries.
GahYoung Baek, Hwanhui Lee, JuHee Ko, Hyung-Kyoon Choi   +3 more
doaj   +1 more source

Untargeted Lipidomics and Chemometric Tools for the Characterization and Discrimination of Irradiated Camembert Cheese Analyzed by UHPLC-Q-Orbitrap-MS

Foods, 2023
In this work, an investigation using UHPLC-Q-Orbitrap-MS and multivariate statistics was conducted to obtain the lipid fingerprint of Camembert cheese and to explore its correlated variation with respect to X-ray irradiation treatment.
Michele Tomaiuolo, Valeria Nardelli, Annalisa Mentana, Maria Campaniello, Rosalia Zianni, Marco Iammarino   +5 more
doaj   +1 more source

Nuclear phosphatidylinositols decrease during S-phase of the cell cycle in HeLa cells.

Journal of Biological Chemistry, 1994
In the current study we have measured phosphatidylinositols during the cell cycle. HeLa cells were labeled with [3H]myoinositol to a steady state, synchronized to the G1/S boundary, and the levels of phosphatidylinositol (PtdIns) lipids were measured at ...
John D. York, P. Majerus
semanticscholar   +1 more source

Lipidomic Analysis of Chlamydomonas reinhardtii under Nitrogen and Sulfur Deprivation. [PDF]

PLoS ONE, 2015
Chlamydomonas reinhardtii accumulates lipids under complete nutrient starvation conditions while overall growth in biomass stops. In order to better understand biochemical changes under nutrient deprivation that maintain production of algal biomass, we ...
Dawei Yang, Donghui Song, Tobias Kind, Yan Ma, Jens Hoefkens, Oliver Fiehn   +5 more
doaj   +1 more source

Metabolic Heavy Isotope Labeling to Study Glycerophospholipid Homeostasis of Cultured Cells

Bio-Protocol, 2017
Glycerophospholipids consist of a glycerophosphate backbone to which are esterified two acyl chains and a polar head group. The head group (e.g., choline, ethanolamine, serine or inositol) defines the glycerophospholipid class, while the acyl chains ...
Satu Hänninen, Pentti Somerharju, Martin Hermansson   +2 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Lipid mapping in human dystrophic muscle by cluster-time-of-flight secondary ion mass spectrometry imaging

Journal of Lipid Research, 2008
Human striated muscle samples, from male control and Duchenne muscular dystrophy-affected children, were subjected to cluster-time-of-flight secondary ion mass spectrometry (cluster-ToF-SIMS) imaging using a 25 keV Bi3+ liquid metal ion gun under static ...
Nora Tahallah, Alain Brunelle, Sabine De La Porte, Olivier Laprévote   +3 more
doaj   +1 more source