Results 51 to 60 of about 22,548 (354)

Cholestasis alters brain lipid and bile acid composition and compromises motor function in neonatal piglets

Physiological Reports, 2022
Infants with neonatal cholestasis are prone to neurodevelopmental deficits, however, the underlying pathogenesis is unclear. Lipid malabsorption and accumulation of potentially neurotoxic molecules in the blood such as bile acids are important yet ...
Nicole Lind Henriksen, Svend Høime Hansen, Matthew Domenic Lycas, Xiaoyu Pan, Thomas Eriksen, Lars Søndergaard Johansen, Richard R. Sprenger, Christer Stenby Ejsing, Douglas G. Burrin, Kerstin Skovgaard, Vibeke Brix Christensen, Thomas Thymann, Stanislava Pankratova   +12 more
doaj   +1 more source

Untargeted Lipidomics and Chemometric Tools for the Characterization and Discrimination of Irradiated Camembert Cheese Analyzed by UHPLC-Q-Orbitrap-MS

Foods, 2023
In this work, an investigation using UHPLC-Q-Orbitrap-MS and multivariate statistics was conducted to obtain the lipid fingerprint of Camembert cheese and to explore its correlated variation with respect to X-ray irradiation treatment.
Michele Tomaiuolo, Valeria Nardelli, Annalisa Mentana, Maria Campaniello, Rosalia Zianni, Marco Iammarino   +5 more
doaj   +1 more source

AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer [PDF]

, 2009
Dysregulation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway occurs frequently in human cancer. PTEN tumor suppressor or PIK3CA oncogene mutations both direct PI3K-dependent tumorigenesis largely through activation of the AKT/PKB kinase ...
Gupta, Piyush, Hoersch, Sebastian, Jacks, Tyler E, Lander, Eric Steven, Sandy, Peter   +4 more
core   +1 more source

Biological characteristics of SARS-CoV-2 resistant populations by integrated gut microbiota sequencing, metabolomics, and proteomics: a cohort comparison study

Frontiers in Medicine
ObjectiveMost research reports on COVID-19 infections have focused on the correlation between the severity of the disease symptoms and immune deficits, while the mechanisms affecting the susceptibility to SARS-CoV-2 remain largely unknown.
Huachong Xu, Haoxuan Li, Junhao Xu, Yaoxin Chen, Li Deng, Xiaoyin Chen, Yinji Xu, Yinji Xu   +7 more
doaj   +1 more source

CircRNA_0001449 disturbs phosphatidylinositol homeostasis and AKT activity by enhancing Osbpl5 translation in transient cerebral ischemia

Redox Biology, 2020
Phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3] is a phosphorylated derivative of phosphatidylinositol 4-phosphate [PI(4)P] and phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], which recruit and activate AKT in the plasma membrane (PM) to ...
Fei-Fei Shang, Li Luo, Jianghong Yan, Qiubo Yu, Yongzheng Guo, Yuchen Wen, Xiao-Li Min, Ling Jiang, Xiang He, Wei Liu   +9 more
doaj   +1 more source

Effects of 3D Geometries on Cellular Gradient Sensing and Polarization

, 2016
During cell migration, cells become polarized, change their shape, and move in response to various internal and external cues. Cell polarization is defined through the spatio-temporal organization of molecules such as PI3K or small GTPases, and is ...
Andasari, Vivi, Kamm, Roger D., Mak, Michael, Spill, Fabian, Zaman, Muhammad H.   +4 more
core   +1 more source

Evaluation of polygenic determinants of non-alcoholic fatty liver disease (NAFLD) by a candidate genes resequencing strategy [PDF]

, 2018
NAFLD is a polygenic condition but the individual and cumulative contribution of identified genes remains to be established. To get additional insight into the genetic architecture of NAFLD, GWAS-identified GCKR, PPP1R3B, NCAN, LYPLAL1 and TM6SF2 genes ...
Angelico F, Angeloni A, Arca M, Bailetti D, Baratta F, Belardinilli F, Ceci F, D'Erasmo L, De Masi B, Del Ben M, Di Costanzo A, Giannini G, Girelli G, Montali A, Pastori D, Polimeni L, Sponziello M   +16 more
core   +1 more source

Identification of a broad lipid repertoire associated to the endothelial cell protein C receptor (EPCR)

Scientific Reports, 2022
Evidence is mounting that the nature of the lipid bound to the endothelial cell protein C receptor (EPCR) has an impact on its biological roles, as observed in anticoagulation and more recently, in autoimmune disease.
Elena Erausquin, María Morán-Garrido, Jorge Sáiz, Coral Barbas, Gilda Dichiara-Rodríguez, Alejandro Urdiciain, Jacinto López-Sagaseta   +6 more
doaj   +1 more source

Examination of the skin barrier repair/wound healing process using a living skin equivalent (LSE) model and matrix-assisted laser desorption-ionization-mass spectrometry imaging (MALDI-MSI). [PDF]

, 2018
Examination of the skin barrier repair/wound healing process using a living skin equivalent (LSE) model and matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) to identify lipids directly involved as potential biomarkers ...
Amen, Beldon, Cajka, Choi, Evans, Fernandis, Gosain, Guest, Guo, Jiang, Koh, Korting, Larjava, McDaniel, Morgan, Nagai, Sasso, Schwamborn, Sen, Stephenson, Thomsen, Tsuji, Yang, Yin   +23 more
core   +2 more sources

Metabolic Heavy Isotope Labeling to Study Glycerophospholipid Homeostasis of Cultured Cells

Bio-Protocol, 2017
Glycerophospholipids consist of a glycerophosphate backbone to which are esterified two acyl chains and a polar head group. The head group (e.g., choline, ethanolamine, serine or inositol) defines the glycerophospholipid class, while the acyl chains ...
Satu Hänninen, Pentti Somerharju, Martin Hermansson   +2 more
doaj   +1 more source