Results 1 to 10 of about 5,307 (115)

Phosphatidylinositol 4-kinases [PDF]

FEBS Journal, 1998
Polyphosphoinositides are involved in many signal transduction pathways in eukaryotic cells. The first committed step is catalysed by phosphatidylinositol 4‐kinase leading to the formation of phosphatidylinositol 4‐phosphate. In the last four years, ten cDNA molecules have been cloned which code isoforms of phosphatidylinositol 4‐kinase; some of which ...
Ludwig M G Heilmeyer, L M Heilmeyer
exaly   +5 more sources

Role of SEC14-like phosphatidylinositol transfer proteins in membrane identity and dynamics

Frontiers in Plant Science, 2023
Membrane identity and dynamic processes, that act at membrane sites, provide important cues for regulating transport, signal transduction and communication across membranes.
Karolin Montag, Rumen Ivanov, Petra Bauer, Petra Bauer   +3 more
doaj   +1 more source

The Genetic Background of Abnormalities in Metabolic Pathways of Phosphoinositides and Their Linkage with the Myotubular Myopathies, Neurodegenerative Disorders, and Carcinogenesis

Biomolecules, 2023
Myo-inositol belongs to one of the sugar alcohol groups known as cyclitols. Phosphatidylinositols are one of the derivatives of Myo-inositol, and constitute important mediators in many intracellular processes such as cell growth, cell differentiation ...
Maria Derkaczew, Piotr Martyniuk, Robert Hofman, Krzysztof Rutkowski, Adam Osowski, Joanna Wojtkiewicz   +5 more
doaj   +1 more source

Physical Properties and Reactivity of Microdomains in Phosphatidylinositol-Containing Supported Lipid Bilayer

Membranes, 2021
We characterized the size, distribution, and fluidity of microdomains in a lipid bilayer containing phosphatidylinositol (PI) and revealed their roles during the two-dimensional assembly of a membrane deformation protein (FBP17).
Toshinori Motegi, Kingo Takiguchi, Yohko Tanaka-Takiguchi, Toshiki Itoh, Ryugo Tero   +4 more
doaj   +1 more source

BIOSYNTHESIS OF PHOSPHATIDYLINOSITOL [PDF]

Annals of the New York Academy of Sciences, 1970
Interest in our laboratory in the inositol lipids derives from the presence of relatively high amounts of phosphatidylinositol phosphate (PhIP) and phosphatidylinositol diphosphate (PhIPP) in excitable tissue. It was with this relationship in mind that we embarked on a study of biosynthetic pathways of inositol lipids several years ago. A first step in
Agranoff, Bernard W., Benjamin, Joyce A., Hajra, Amiya K.   +2 more
openaire   +3 more sources

SAC1 regulates autophagosomal phosphatidylinositol-4-phosphate for xenophagy-directed bacterial clearance

Cell Reports, 2021
Summary: Phosphoinositides are important molecules in lipid signaling, membrane identity, and trafficking that are spatiotemporally controlled by factors from both mammalian cells and intracellular pathogens.
Kai Liu, Lingjia Kong, Daniel B. Graham, Kimberly L. Carey, Ramnik J. Xavier   +4 more
doaj   +1 more source

Early Serum Metabolism Profile of Post-operative Delirium in Elderly Patients Following Cardiac Surgery With Cardiopulmonary Bypass

Frontiers in Aging Neuroscience, 2022
BackgroundCardiac surgery with cardiopulmonary bypass (CPB) is considered to be one of the surgical types with the highest incidence of post-operative delirium (POD).
He Huang, Jingjing Han, Yan Li, Yonglin Yang, Jian Shen, Qiang Fu, Yu Chen   +6 more
doaj   +1 more source

Phosphatidylinositol Stabilizes Fluid-Phase Liposomes Loaded with a Melphalan Lipophilic Prodrug

Pharmaceutics, 2021
Previously, a liposomal formulation of a chemotherapeutic agent melphalan (Mlph) incorporated in a fluid lipid bilayer of natural phospholipids in the form of dioleoylglyceride ester (MlphDG) was developed and the antitumor effect was confirmed in mouse ...
Daria Tretiakova, Irina Le-Deigen, Natalia Onishchenko, Judith Kuntsche, Elena Kudryashova, Elena Vodovozova   +5 more
doaj   +1 more source

Genetic Analysis and Molecular Mapping of the Quantitative Trait Loci Governing Low Phytic Acid Content in a Novel LPA Rice Mutant, PLM11

Plants, 2020
Breeding rice varieties with a low phytic acid (LPA) content is an effective strategy to overcome micronutrient deficiency in a population which consume rice as a staple food.
Prem Chand Gyani, Haritha Bollinedi, Subbaiyan Gopala Krishnan, Kunnummal Kurungara Vinod, Archana Sachdeva, Prolay Kumar Bhowmick, Ranjith Kumar Ellur, Mariappan Nagarajan, Ashok Kumar Singh   +8 more
doaj   +1 more source

Drosophila Lipase 3 Mediates the Metabolic Response to Starvation and Aging

Frontiers in Aging, 2022
The human LIPA gene encodes for the enzyme lysosomal acid lipase, which hydrolyzes cholesteryl ester and triacylglycerol. Lysosomal acid lipase deficiency results in Wolman disease and cholesteryl ester storage disease.
Lea Hänschke, Christoph Heier, Christoph Heier, Christoph Heier, Santiago José Maya Palacios, Huseyin Erdem Özek, Christoph Thiele, Reinhard Bauer, Ronald P. Kühnlein, Ronald P. Kühnlein, Ronald P. Kühnlein, Margret H. Bülow   +11 more
doaj   +1 more source