Results 1 to 10 of about 26,600 (143)

6-PPD Quinone Inhibits Phosphatidic Acid Synthesis Associated with an Increase in Intestinal Barrier Permeability in C. elegans [PDF]

Toxics
6-PPD quinine (6-PPDQ) affects intestinal barrier function; however, its underlying mechanisms remain largely unknown. In the current study, we examined the role of reduction in phosphatidic acid synthesis in mediating the toxicity of 6-PPDQ in affecting
Jingwei Wu, Qian Bian, Dayong Wang
doaj   +2 more sources

Phosphatidic acid is an endogenous negative regulator of PIEZO2 channels and mechanical sensitivity [PDF]

Nature Communications
Mechanosensitive PIEZO2 ion channels play roles in touch, proprioception, and inflammatory pain. Currently, there are no small molecule inhibitors that selectively inhibit PIEZO2 over PIEZO1. The TMEM120A protein was shown to inhibit PIEZO2 while leaving
Matthew Gabrielle, Yevgen Yudin, Yujue Wang, Xiaoyang Su, Tibor Rohacs   +4 more
doaj   +2 more sources

Cyclic Phosphatidic Acid Relieves Osteoarthritis Symptoms

Molecular Pain, 2014
Background: Cyclic phosphatidic acid (cPA) is a naturally occurring phospholipid mediator with a unique cyclic phosphate ring at the sn -2 and sn -3 positions of its glycerol backbone. Natural cPA and its chemically stabilized cPA derivative, 2-carba-cPA
Mari Gotoh, Aya Nagano, Ryoko Tsukahara, Hiromu Murofushi, Toshiro Morohoshi, Kazuyuki Otsuka, Kimiko Murakami-Murofushi   +6 more
doaj   +2 more sources

DDHD1, but Not DDHD2, Suppresses Neurite Outgrowth in SH-SY5Y and PC12 Cells by Regulating Protein Transport From Recycling Endosomes

Frontiers in Cell and Developmental Biology, 2020
DDHD1 and DDHD2 are both intracellular phospholipases A1 and hydrolyze phosphatidic acid in vitro. Given that phosphatidic acid participates in neurite outgrowth, we examined whether DDHD1 and DDHD2 regulate neurite outgrowth.
Yuki Maemoto, Tomohiro Maruyama, Kazuaki Nemoto, Takashi Baba, Takashi Baba, Manae Motohashi, Akihiro Ito, Mitsuo Tagaya, Katsuko Tani   +8 more
doaj   +1 more source

The PDZ domain of the guanine nucleotide exchange factor PDZGEF directs binding to phosphatidic acid during brush border formation. [PDF]

PLoS ONE, 2014
PDZGEF is a guanine nucleotide exchange factor for the small G protein Rap. It was recently found that PDZGEF contributes to establishment of intestinal epithelial polarity downstream of the kinase Lkb1.
Sarah V Consonni, Patricia M Brouwer, Eleonora S van Slobbe, Johannes L Bos   +3 more
doaj   +1 more source

Effects of ionization and counterion binding on the surface areas of phosphatidic acids in monolayers.

Journal of Lipid Research, 1979
At 24-26 degrees C, force-area isotherms show that unionized dipalmitoyl phosphatidic acid forms a solid-condensed film while unionized egg and dioleoyl phosphatidic acids form liquid-expanded films. Surface area is a characteristic feature of a specific
G S Patil, N J Dorman, D G Cornwell
doaj   +1 more source

Phosphatidic acid modulation of Kv channel voltage sensor function

eLife, 2014
Membrane phospholipids can function as potent regulators of ion channel function. This study uncovers and investigates the effect of phosphatidic acid on Kv channel gating.
Richard K Hite, Joel A Butterwick, Roderick MacKinnon   +2 more
doaj   +1 more source

Antiviral nucleoside diphosphate diglycerides: improved synthesis and facilitated purification.

Journal of Lipid Research, 1992
Cytidine diphosphate diglyceride and its analogs have previously been synthesized by condensing phosphatidic acid with the monophosphomorpholidates of the various nucleosides. Yields have been low and purification of the product has been difficult.
GM van Wijk, KY Hostetler, H van den Bosch   +2 more
doaj   +1 more source

Apparent convergence (at 2-monoacylglycerol level) of phosphatidic acid and 2-monoacylglycerol pathways of synthesis of chylomicron triacylglycerols.

Journal of Lipid Research, 1991
Dietary fats are converted into chylomicron triacylglycerols via the 2-monoacylglycerol and phosphatidic acid pathways of acylglycerol formation. In view of the known positional and fatty acid specificity of the acyltransferases, the triacylglycerol ...
LY Yang, A Kuksis
doaj   +1 more source

Synthesis of all-cis-1,3-diacylcyclopentane-1,2,3-triol-2-phosphate via acyl group migration in a cyclic diglyceride analog.

Journal of Lipid Research, 1979
The acid-catalyzed isomerization of the diglyceride analog (1,2,3/0)-1,2-dipalmitoylcyclopentane-1,2,3-triol has been used to generate syn-syn-1,3-diacyl-cyclopentane-1,2,3-triol, a required intermediate in the synthesis of a symmetrical all-cis-1,2,3/0 ...
A J Hancock, M D Lister
doaj   +1 more source