Results 31 to 40 of about 11,249 (206)

A human phospholipid phosphatase activated by a transmembrane control module

Journal of Lipid Research, 2012
In voltage-sensitive phosphatases (VSPs), a transmembrane voltage sensor domain (VSD) controls an intracellular phosphoinositide phosphatase domain, thereby enabling immediate initiation of intracellular signals by membrane depolarization.
Christian R. Halaszovich, Michael G. Leitner, Angeliki Mavrantoni, Audrey Le, Ludivine Frezza, Anja Feuer, Daniela N. Schreiber, Carlos A. Villalba-Galea, Dominik Oliver   +8 more
doaj   +1 more source

Functional studies of the mammalian Sac1 phosphoinositide phosphatase [PDF]

Advances in Enzyme Regulation, 2009
The Sac1 PIP phosphatase is an enigmatic enzyme in that it occupies an intracellular location (ER) that is not normally associated with PIP signaling. Yet, genetic experiments in mice and silencing experiments in cultured cells report an essential housekeeping function for this protein.
Yang, Liu, Malika, Boukhelifa, Emily, Tribble, Vytas A, Bankaitis   +3 more
openaire   +2 more sources

α-Synuclein plasma membrane localization correlates with cellular phosphatidylinositol polyphosphate levels

eLife, 2021
The Parkinson’s disease protein α-synuclein (αSyn) promotes membrane fusion and fission by interacting with various negatively charged phospholipids. Despite postulated roles in endocytosis and exocytosis, plasma membrane (PM) interactions of αSyn are ...
Reeba Susan Jacob, Cédric Eichmann, Alessandro Dema, Davide Mercadante, Philipp Selenko   +4 more
doaj   +1 more source

Control of autophagy initiation by phosphoinositide 3‐phosphatase jumpy [PDF]

The EMBO Journal, 2009
The majority of studies on autophagy, a cytoplasmic homeostasis pathway of broad biological and medical significance, have been hitherto focused on the phosphatidylinositol 3-kinases as the regulators of autophagy. Here, we addressed the reverse process driven by phosphoinositide phosphatases and uncovered a key negative regulatory role in autophagy of
Vergne, Isabelle, Roberts, Esteban, Elmaoued, Rasha, Tosch, Valérie, Delgado, Mónica, Proikas-Cezanne, Tassula, Laporte, Jocelyn, Deretic, Vojo   +7 more
openaire   +2 more sources

Dynamics of receptor-operated Ca2+ Currents Through TRPC Channels Controlled via the PI(4,5)P2-PLC Signaling Pathway

Frontiers in Pharmacology, 2015
Transient receptor potential canonical (TRPC) channels are Ca2+-permeable, nonselective cation channels that carry receptor-operated Ca2+ currents (ROCs) triggered by receptor-induced, phospholipase C (PLC)-catalyzed hydrolysis of phosphatidylinositol 4 ...
Masayuki X Mori, Kyohei eItsuki, Hideharu eHase, Seishirou eSawamura, Tatsuki eKurokawa, Yasuo eMori, Ryuji eInoue   +6 more
doaj   +1 more source

Phosphoinositide Lipid Phosphatases: Natural Regulators of Phosphoinositide 3-Kinase Signaling in T Lymphocytes [PDF]

Journal of Biological Chemistry, 2008
The phosphoinositide 3-kinase signaling pathway has been implicated in a range of T lymphocyte cellular functions, particularly growth, proliferation, cytokine secretion, and survival. Dysregulation of phosphoinositide 3-kinase-dependent signaling and function in leukocytes, including B and T lymphocytes, has been implicated in many inflammatory and ...
Stephanie J, Harris, Richard V, Parry, John, Westwick, Stephen G, Ward   +3 more
openaire   +2 more sources

Phosphoinositide Lipids in Ocular Tissues

Biology, 2020
Inositol phospholipids play an important role in cell physiology. The inositol head groups are reversibly phosphorylated to produce seven distinct phosphorylated inositides, commonly referred to as phosphoinositides (PIs). These seven PIs are dynamically
Ammaji Rajala, Austin McCauley, Richard S. Brush, Khuong Nguyen, Raju V.S. Rajala   +4 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Mass spectrometry imaging and LC/MS reveal decreased cerebellar phosphoinositides in Niemann-Pick type C1-null mice[S]

Journal of Lipid Research, 2020
Niemann-Pick disease type C1 (NPC1) is a lipid storage disorder in which cholesterol and glycosphingolipids accumulate in late endosomal/lysosomal compartments because of mutations in the NPC1 gene.
Koralege C. Pathmasiri, Melissa R. Pergande, Fernando Tobias, Rima Rebiai, Avia Rosenhouse-Dantsker, Ernesto R. Bongarzone, Stephanie M. Cologna   +6 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source