High-expressed PTPN1 promotes tumor proliferation signature in human hepatocellular carcinoma
Heliyon, 2023 Hepatocellular carcinoma (HCC) is a highly prevalent malignant tumor that is associated with substantial morbidity and mortality rates. Despite the progress made in diagnostic technology, the survival rate of HCC patients remains unsatisfactory due to ...
Liping Xie +5 more
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Role of protein tyrosine phosphatase non-receptor type 7 in the regulation of TNF-α production in RAW 264.7 macrophages. [PDF]
PLoS ONE, 2013 Protein tyrosine phosphatases play key roles in a diverse range of cellular processes such as differentiation, cell proliferation, apoptosis, immunological signaling, and cytoskeletal function.
Huiyun Seo +6 more
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Frontiers in Physiology, 2020 Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator in the insulin signaling pathway. It belongs to a class of non-receptor phosphatases of protein tyrosine phosphatase and can catalyze the dephosphorylation of tyrosine to regulate cell ...
Kang-Kang Xu +4 more
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Glypicans and Heparan Sulfate in Synaptic Development, Neural Plasticity, and Neurological Disorders
Frontiers in Neural Circuits, 2021 Heparan sulfate proteoglycans (HSPGs) are components of the cell surface and extracellular matrix, which bear long polysaccharides called heparan sulfate (HS) attached to the core proteins.
Keisuke Kamimura, Nobuaki Maeda
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BAR Proteins PSTPIP1/2 Regulate Podosome Dynamics and the Resorption Activity of Osteoclasts. [PDF]
PLoS ONE, 2016 Bone resorption in vertebrates relies on the ability of osteoclasts to assemble F-actin-rich podosomes that condense into podosomal belts, forming sealing zones.
Martin Sztacho +5 more
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Central regulation of metabolism by protein tyrosine phosphatases
Frontiers in Neuroscience, 2013 Protein tyrosine phosphatases (PTPs) are important regulators of intracellular signaling pathways via the dephosphorylation of phosphotyrosyl residues on various receptor and non-receptor substrates.
Ryan eTsou, Kendra eBence
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The FERM and PDZ domain-containing protein tyrosine phosphatases, PTPN4 and PTPN3, are both dispensable for T cell receptor signal transduction. [PDF]
PLoS ONE, 2008 PTPN3 and PTPN4 are two closely-related non-receptor protein tyrosine phosphatases (PTP) that, in addition to a PTP domain, contain FERM (Band 4.1, Ezrin, Radixin, and Moesin) and PDZ (PSD-95, Dlg, ZO-1) domains. Both PTP have been implicated as negative-
Timothy J Bauler +2 more
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Molecules, 2018 Protein tyrosine phosphatases (PTPs), of the receptor and non-receptor classes, are key signaling molecules that play critical roles in cellular regulation underlying diverse physiological events.
Yotis A. Senis, Alastair J. Barr
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PTPN11 Is a Central Node in Intrinsic and Acquired Resistance to Targeted Cancer Drugs
Cell Reports, 2015 Most BRAF (V600E) mutant melanomas are sensitive to selective BRAF inhibitors, but BRAF mutant colon cancers are intrinsically resistant to these drugs because of feedback activation of EGFR.
Anirudh Prahallad +11 more
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Comprehensive analysis of PTPN family expression and prognosis in acute myeloid leukemia
Frontiers in Genetics, 2023 Background: Tyrosyl phosphorylation is carried out by a group of enzymes known as non-receptor protein tyrosine phosphatases (PTPNs). In the current investigation, it is hoped to shed light on the relationships between the expression patterns of PTPN ...
Yong Liu +8 more
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