Results 31 to 40 of about 30,230 (147)

PTPN21 (protein tyrosine phosphatase, non-receptor type 21) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on PTPN21 (protein tyrosine phosphatase, non-receptor type 21), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +1 more source

Targeting Protein Tyrosine Phosphatases to Improve Cancer Immunotherapies

Cells
Advances in immunotherapy have brought significant therapeutic benefits to many cancer patients. Nonetheless, many cancer types are refractory to current immunotherapeutic approaches, meaning that further targets are required to increase the number of ...
Robert J. Salmond
doaj   +1 more source

Syk inhibitors reduce tau protein phosphorylation and oligomerization

Neurobiology of Disease
Spleen tyrosine kinase (Syk), a non-receptor-type tyrosine kinase, has a wide range of physiological functions. A possible role of Syk in Alzheimer's disease (AD) has been proposed.
Tomohisa Yamaguchi, Tadanori Hamano, Kiyonao Sada, Rei Asano, Nicholas M. Kanaan, Hirohito Sasaki, Shu-Hui Yen, Yuki Kitazaki, Yoshinori Endo, Soichi Enomoto, Norimichi Shirafuji, Masamichi Ikawa, Osamu Yamamura, Youshi Fujita, Koji Aoki, Hironobu Naiki, Maho Morishima, Yuko Saito, Shigeo Murayama, Yasunari Nakamoto   +19 more
doaj   +1 more source

Redundancy and compensation in axon guidance: genetic analysis of the Drosophila Ptp10D/Ptp4E receptor tyrosine phosphatase subfamily

Neural Development, 2008
Background Drosophila has six receptor protein tyrosine phosphatases (RPTPs), five of which are expressed primarily in neurons. Mutations in all five affect axon guidance, either alone or in combination.
Bahri Sami, Nguyen Huong, Jeon Mili, Zinn Kai   +3 more
doaj   +1 more source

Association of the protein tyrosine phosphatase non-receptor 22 polymorphism (PTPN22) with endometriosis: a meta-analysis [PDF]

Einstein (São Paulo), 2017
ABSTRACT Objective To evaluate PTPN22 C1858T polymorphism and the risk of endometriosis. Methods A meta-analysis of 10 published case-control studies (from four articles), with a total sample of 971 cases and 1,181 controls, was performed. We estimated risk (odds ratio and 95% confidence intervals) of endometriosis associations with the C1858T ...
Pabalan, Noel, Jarjanazi, Hamdi, Christofolini, Denise Maria, Bianco, Bianca, Barbosa, Caio Parente   +4 more
openaire   +5 more sources

Phosphatase Dysregulation in Cancer: Signaling Pathways and Therapeutic Opportunities

MedComm – Oncology
Phosphatases are increasingly recognized as critical regulators of cancer biology, with important roles in both tumor cells and the tumor immune microenvironment (TIME).
Maryam Jama, Michael Overduin, Khaled H. Barakat   +2 more
doaj   +1 more source

Phospho-activated non-muscle myosin IIA heavy chain supports different mechanisms of virus uptake

Journal of Virology
Limiting virus entry is crucial to prevent infection, since this step of the virus life cycle is a major determinant of cellular tropism, host range, and pathogenesis.
Natalia Ansin, Kathia Guardado, Matías Ponce, María Paz García, Camila Ladra, Irene Ferreiro, Gonzalo Moratorio, Nicolás Sarute   +7 more
doaj   +1 more source

Protein tyrosine phosphatase non-receptor type 2 and inflammatory bowel disease

World Journal of Gastroenterology, 2016
Genome wide association studies have associated single nucleotide polymorphisms within the gene locus encoding protein tyrosine phosphatase non-receptor type 2 (PTPN2) with the onset of inflammatory bowel disease (IBD) and other inflammatory disorders.
Spalinger, Marianne R, McCole, Declan F, Rogler, Gerhard, Scharl, Michael   +3 more
openaire   +5 more sources

Protein tyrosine phosphatase PTPRO represses lung adenocarcinoma progression by inducing mitochondria-dependent apoptosis and restraining tumor metastasis

Cell Death and Disease
Emerging evidence indicates that protein activities regulated by receptor protein tyrosine phosphatases (RPTPs) are crucial for a variety of cellular processes, such as proliferation, apoptosis, and immunological response.
Yuan Dai, Shuangshuang Shi, Hongda Liu, Hong Zhou, Wenqiu Ding, Chenyang Liu, Linling Jin, Weiping Xie, Hui Kong, Qun Zhang   +9 more
doaj   +1 more source

PTPN13 (Protein tyrosine phosphatase, non-receptor type 13) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on PTPN13 (Protein tyrosine phosphatase, non-receptor type 13), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +2 more sources