Results 41 to 50 of about 30,230 (147)

Protein tyrosine phosphatase non-receptor type 22 modulates colitis in a microbiota-dependent manner [PDF]

Journal of Clinical Investigation, 2019
The gut microbiota is crucial for our health, and well-balanced interactions between the host's immune system and the microbiota are essential to prevent chronic intestinal inflammation, as observed in inflammatory bowel diseases (IBD). A variant in protein tyrosine phosphatase non-receptor type 22 (PTPN22) is associated with reduced risk of developing
Marianne R. Spalinger, Thomas S.B. Schmidt, Marlene Schwarzfischer, Larissa Hering, Kirstin Atrott, Silvia Lang, Claudia Gottier, Annelies Geirnaert, Christophe Lacroix, Xuezhi Dai, David J. Rawlings, Andrew C. Chan, Christian von Mering, Gerhard Rogler, Michael Scharl   +14 more
openaire   +4 more sources

The phosphatidylinositol-5′ phosphatase synaptojanin1 limits integrin-mediated invasion of Staphylococcus aureus

Microbiology Spectrum
The gram-positive bacterium Staphylococcus aureus can invade non-professional phagocytic cells by associating with the plasma protein fibronectin to exploit host cell integrins.
Yong Shi, Petra Muenzner, Stefanie Schanz-Jurinka, Christof R. Hauck   +3 more
doaj   +1 more source

Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex

Communications Chemistry
PTPN2 (protein tyrosine phosphatase non-receptor type 2, or TC-PTP) and PTPN1 are attractive immuno-oncology targets, with the deletion of Ptpn1 and Ptpn2 improving response to immunotherapy in disease models.
Qi Hao, Manoj K. Rathinaswamy, Kelly L. Klinge, Matthew Bratkowski, Amirhossein Mafi, Christina K. Baumgartner, Keith M. Hamel, Gesine K. Veits, Rinku Jain, Claudio Catalano, Mark Fitzgerald, Alexander W. Hird, Eunice Park, Harit U. Vora, James A. Henderson, Kenton Longenecker, Charles W. Hutchins, Wei Qiu, Giovanna Scapin, Qi Sun, Vincent S. Stoll, Chaohong Sun, Ping Li, Dan Eaton, David Stokoe, Stewart L. Fisher, Christopher G. Nasveschuk, Marcia Paddock, Michael E. Kort   +28 more
doaj   +1 more source

Neuroimmune pathways involvement in neurodegeneration of R6/2 mouse model of Huntington’s disease

Frontiers in Cellular Neuroscience
Mechanisms of tissue damage in Huntington’s disease (HD) involve excitotoxicity, mitochondrial damage, and neuroinflammation, including microglia activation. CD47 is a membrane protein that interacts with the inhibitory immunoreceptor SIRPα.
Emanuela Paldino, Giorgia Migliorato, Giorgia Migliorato, Francesca R. Fusco   +3 more
doaj   +1 more source

A conserved protein tyrosine phosphatase, PTPN-22, functions in diverse developmental processes in C. elegans.

PLoS Genetics
Protein tyrosine phosphatases non-receptor type (PTPNs) have been studied extensively in the context of the adaptive immune system; however, their roles beyond immunoregulation are less well explored. Here we identify novel functions for the conserved C.
Shaonil Binti, Adison G Linder, Philip T Edeen, David S Fay   +3 more
doaj   +1 more source

Protein Tyrosine Phosphatase Non-Receptor Type 22 Modulates NOD2-Induced Cytokine Release and Autophagy

PLoS ONE, 2013
BACKGROUND: Variations within the gene locus encoding protein tyrosine phosphatase non-receptor type 22 (PTPN22) are associated with the risk to develop inflammatory bowel disease (IBD). PTPN22 is involved in the regulation of T- and B-cell receptor signaling, but although it is highly expressed in innate immune cells, its function in other signaling ...
Spalinger, Marianne R, Lang, Silvia, Vavricka, Stephan R, Fried, Michael, Rogler, Gerhard, Scharl, Michael   +5 more
openaire   +6 more sources

Non-Receptor Protein Tyrosine Phosphatase Gene [PDF]

, 2020
openaire   +1 more source

Non-Receptor Type Protein Tyrosine Phosphatase [PDF]

, 2020
openaire   +1 more source

Tyrosine-Protein Phosphatase Non-Receptor Type 21 [PDF]

, 2020
openaire   +1 more source

Tyrosine-Protein Phosphatase Non-Receptor Type 13 [PDF]

, 2020
openaire   +1 more source