Phosphoinositide phosphatases: Modifiers of phosphoinositide signaling in health and disease
Biochimica Et Biophysica Acta - Molecular and Cell Biology of LipidsPhosphoinositides are membrane-bound phospholipids that are derived from the reversible phosphorylation of phosphatidylinositol by the opposing actions of phosphoinositide kinases and phosphatases. Phosphoinositides are minor lipid constituents of cellular membranes; however, they assert a varied and profound influence on numerous biological processes ...
Christina A Mitchell +2 more
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Manipulation of macrophage signaling by Leishmania virulence factors [PDF]
VirulenceLeishmania, a macrophage-residing parasite, expresses virulence factors that intercept macrophage signaling and inflicts leishmaniasis. Recently described virulence factors- eEF-1α (eukaryotic elongation factor), LmjF_36_3850 (Leishmania major F_36_3850),
Dhiraj Gurjar +5 more
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Functional Characterization of MIP_07528 of Mycobacterium indicus pranii for Tyrosine Phosphatase Activity Displays Sensitivity to Oxidative Inactivation and Plays a Role in Immunomodulation [PDF]
BiologyMycobacterium indicus pranii (MIP), an atypical mycobacterium originally developed as an anti-leprosy vaccine, has emerged as a potent immunomodulator with diverse therapeutic applications.
Raunak Raunak +6 more
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Phospholipid Networks as Metabolic Hubs and Signaling Integrators in Plant Development and Stress Adaptation [PDF]
PlantsPhospholipids function as dynamic regulators of plant growth and environmental adaptation, extending well beyond their structural roles in biological membranes.
Pengjie Chang +10 more
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Phosphoinositide Signaling in Immune Cell Migration
Biomolecules, 2023 In response to different immune challenges, immune cells migrate to specific sites in the body, where they perform their functions such as defense against infection, inflammation regulation, antigen recognition, and immune surveillance.
Ruchi Kakar, Chinmoy Ghosh, Yue Sun
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Signaling roles of phosphoinositides in the retina
Journal of Lipid Research, 2021 The field of phosphoinositide signaling has expanded significantly in recent years. Phosphoinositides (also known as phosphatidylinositol phosphates or PIPs) are universal signaling molecules that directly interact with membrane proteins or with ...
Raju V.S. Rajala
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The 5-Phosphatase SHIP2 Promotes Neutrophil Chemotaxis and Recruitment
Frontiers in Immunology, 2021 Neutrophils, the most abundant circulating leukocytes in humans have key roles in host defense and in the inflammatory response. Agonist-activated phosphoinositide 3-kinases (PI3Ks) are important regulators of many facets of neutrophil biology.
Melina Michael +7 more
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The Role of Primary Cilia-Associated Phosphoinositide Signaling in Development
Journal of Developmental Biology, 2022 Primary cilia are microtube-based organelles that extend from the cell surface and function as biochemical and mechanical extracellular signal sensors. Primary cilia coordinate a series of signaling pathways during development. Cilia dysfunction leads to
Chuan Chen, Jinghua Hu, Kun Ling
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The Role of Phosphatidylinositol Phosphate Kinases during Viral Infection
Viruses, 2020 Phosphoinositides account for only a small proportion of cellular phospholipids, but have long been known to play an important role in diverse cellular processes, such as cell signaling, the establishment of organelle identity, and the regulation of ...
Anne Beziau, Denys Brand, Eric Piver
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Frontiers in Cell and Developmental Biology, 2021 Primary cilia are evolutionary conserved microtubule-based organelles that protrude from the surface of most mammalian cells. Phosphoinositides (PI) are membrane-associated signaling lipids that regulate numerous cellular events via the recruitment of ...
Sarah E. Conduit +4 more
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