Results 11 to 20 of about 27,020 (299)

Key role of polyphosphoinositides in dynamics of fusogenic nuclear membrane vesicles. [PDF]

PLoS ONE, 2011
The role of phosphoinositides has been thoroughly described in many signalling and membrane trafficking events but their function as modulators of membrane structure and dynamics in membrane fusion has not been investigated.
Vanessa Zhendre, Axelle Grélard, Marie Garnier-Lhomme, Sébastien Buchoux, Banafshé Larijani, Erick J Dufourc   +5 more
doaj   +1 more source

The Arabidopsis SAC9 enzyme is enriched in a cortical population of early endosomes and restricts PI(4,5)P2 at the plasma membrane

eLife, 2022
Membrane lipids, and especially phosphoinositides, are differentially enriched within the eukaryotic endomembrane system. This generates a landmark code by modulating the properties of each membrane.
Alexis Lebecq, Mehdi Doumane, Aurelie Fangain, Vincent Bayle, Jia Xuan Leong, Frédérique Rozier, Maria del Marques-Bueno, Laia Armengot, Romain Boisseau, Mathilde Laetitia Simon, Mirita Franz-Wachtel, Boris Macek, Suayib Üstün, Yvon Jaillais, Marie-Cécile Caillaud   +14 more
doaj   +1 more source

Phosphoinositide Profile of the Mouse Retina

Cells, 2020
Phosphoinositides are known to play multiple roles in eukaryotic cells. Although dysregulation of phosphoinositide metabolism in the retina has been reported to cause visual dysfunction in animal models and human patients, our understanding of the ...
Stella Finkelstein, Sidney M. Gospe, Kai Schuhmann, Andrej Shevchenko, Vadim Y. Arshavsky, Ekaterina S. Lobanova   +5 more
doaj   +1 more source

Phosphoinositide 3-kinase is associated to the nucleus of HL-60 cells and is involved in their ATRA-induced granulocytic differentiation

European Journal of Histochemistry, 2009
Phosphoinositide 3-kinases (PI 3-kinases), a class of enzymes implicated in growth factor-induced mitogenic response and many other intracellular signalling pathways, act by phosphorylation at the D-3’-OH position of the myo-inositol ring of ...
V. Bertagnolo, A. Gonelli, F. Brugnoli, L.M. Neri, M. Marchisio   +4 more
doaj   +3 more sources

Animal cell cytokinesis: the role of dynamic changes in the plasma membrane proteome and lipidome [PDF]

, 2016
In animal cells, cytokinesis is characterised by the formation of the mitotic spindle that signals the assembly of an actomyosin ring between the spindle poles.
Gould, Gwyn W.
core   +2 more sources

A human stem cell resource to decipher the biochemical and cellular basis of neurodevelopmental defects in Lowe syndrome

Biology Open, 2022
Human brain development is a complex process where multiple cellular and developmental events are coordinated to generate normal structure and function.
Bilal M. Akhtar, Priyanka Bhatia, Shubhra Acharya, Sanjeev Sharma, Yojet Sharma, Aswathy Bhuvanendran Nair Suseela Devi, Kavina Ganapathy, Anil Vasudevan, Padinjat Raghu   +8 more
doaj   +1 more source

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase [PDF]

, 2014
The Vps34 (vacuolar protein sorting 34) class III PI3K (phosphoinositide 3-kinase) phosphorylates PtdIns (phosphatidylinositol) at endosomal membranes to generate PtdIns(3)P that regulates membrane trafficking processes via its ability to recruit a ...
Alessi, Dario R., Bago, Ruzica, Cross, Darren, Davies, Paul, Ganley, Ian G., Malik, Nazma, Munson, Michael J., Prescott, Alan R., Shpiro, Natalia, Sommer, Eeva, Ward, Richard   +10 more
core   +3 more sources

Phosphoinositides and phagocytosis [PDF]

The Journal of Cell Biology, 2001
Phosphoinositide 3 kinases (PI3Ks)**Abbreviation used in this paper: PI3K, phosphoinositide 3 kinase. are known as regulators of phagocytosis. Recent results demonstrate that class I and III PI3Ks act consecutively in phagosome formation and maturation, and that their respective products, phosphatidylinositol 3,4,5-trisphosphate (PI[3,4,5]P3) and ...
Gillooly, David J., Simonsen, Anne, Stenmark, Harald   +2 more
openaire   +2 more sources

Mechanism of NaCl transport-stimulated prostaglandin formation in MDCK cells [PDF]

, 1987
Recently we have found that stimulation of NaCl transport in high-resistance MDCK cells enhances their prostaglandin formation. In the present study, we investigated the mechanisms by which prostaglandin formation could be linked to the ion transport in ...
Bauer, C., Kurtz, Armin, Malmström, K., Pfeilschifter, J., Woodson, R. D.   +4 more
core   +1 more source

Diverse Physiological Functions of FAB1 and Phosphatidylinositol 3,5-Bisphosphate in Plants

Frontiers in Plant Science, 2019
Biological membranes are predominantly composed of structural glycerophospholipids such as phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol. Of the membrane glycerophospholipids, phosphatidylinositol (PtdIns) and its phosphorylated
Tomoko Hirano, Masa H. Sato
doaj   +1 more source