Results 11 to 20 of about 13,157 (254)
Phosphoinositides in the kidney [PDF]
Journal of Lipid Research, 2019 Phosphoinositides (PIs) play pivotal roles in the regulation of many biological processes. The quality and quantity of PIs is regulated in time and space by the activity of PI kinases and PI phosphatases. The number of PI-metabolizing enzymes exceeds the number of PIs with, in many cases, more than one enzyme controlling the same biochemical step. This
Staiano, Leopoldo +1 more
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Frontiers in Cell and Developmental Biology, 2021 Primary cilia are evolutionary conserved microtubule-based organelles that protrude from the surface of most mammalian cells. Phosphoinositides (PI) are membrane-associated signaling lipids that regulate numerous cellular events via the recruitment of ...
Sarah E. Conduit +4 more
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When PIP2 Meets p53: Nuclear Phosphoinositide Signaling in the DNA Damage Response
Frontiers in Cell and Developmental Biology, 2022 The mechanisms that maintain genome stability are critical for preventing tumor progression. In the past decades, many strategies were developed for cancer treatment to disrupt the DNA repair machinery or alter repair pathway selection.
Yu-Hsiu Wang, Michael P. Sheetz
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Phosphoinositides and phagocytosis [PDF]
The Journal of Cell Biology, 2001 Phosphoinositide 3 kinases (PI3Ks)**Abbreviation used in this paper: PI3K, phosphoinositide 3 kinase. are known as regulators of phagocytosis. Recent results demonstrate that class I and III PI3Ks act consecutively in phagosome formation and maturation, and that their respective products, phosphatidylinositol 3,4,5-trisphosphate (PI[3,4,5]P3) and ...
Gillooly, David J. +2 more
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Key role of polyphosphoinositides in dynamics of fusogenic nuclear membrane vesicles. [PDF]
PLoS ONE, 2011 The role of phosphoinositides has been thoroughly described in many signalling and membrane trafficking events but their function as modulators of membrane structure and dynamics in membrane fusion has not been investigated.
Vanessa Zhendre +5 more
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Acutely Modifying Phosphatidylinositol Phosphates on Endolysosomes Using Chemically Inducible Dimerization Systems. [PDF]
Bio ProtocPhosphoinositides are rare membrane lipids that mediate cell signaling and membrane dynamics. PI(4)P and PI(3)P are two major phosphoinositides crucial for endolysosomal functions and dynamics, making them the lipids of interest in many studies.
Yap WS, Kim PK, Boutry M.
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Lipidation as a post-translational code for protein liquid-liquid phase separation. [PDF]
J Lipid ResLiquid–liquid phase separation has emerged as a central organizing mechanism that drives the formation of biomolecular condensates and enables cells to spatially and temporally coordinate metabolism, signaling, and gene expression. While the influence of
Sani SA, Chytła A, Sztacho M.
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Dysregulation of Phosphoinositide 5-Phosphatases and Phosphoinositides in Alzheimer's Disease [PDF]
Frontiers in Neuroscience, 2021 info:eu-repo/semantics ...
Ando, Kunie +6 more
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PHOSPHOINOSITIDE KINASES [PDF]
Annual Review of Biochemistry, 1998 Phosphatidylinositol, a component of eukaryotic cell membranes, is unique among phospholipids in that its head group can be phosphorylated at multiple free hydroxyls. Several phosphorylated derivatives of phosphatidylinositol, collectively termed phosphoinositides, have been identified in eukaryotic cells from yeast to mammals.
D A, Fruman, R E, Meyers, L C, Cantley
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eLife, 2022 Membrane lipids, and especially phosphoinositides, are differentially enriched within the eukaryotic endomembrane system. This generates a landmark code by modulating the properties of each membrane.
Alexis Lebecq +14 more
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