Results 31 to 40 of about 13,157 (254)

DNA damage causes rapid accumulation of phosphoinositides for ATR signaling

Nature Communications, 2017
Phosphoinositides are enriched in the nucleus and accumulate upon DNA damage but their role in responding to DNA damage is poorly defined. Here, the authors show that phosphoinositides rapidly accumulate at DNA damage sites and are required for ATR ...
Yu-Hsiu Wang, Anushya Hariharan, Giulia Bastianello, Yusuke Toyama, G. V. Shivashankar, Marco Foiani, Michael P. Sheetz   +6 more
doaj   +1 more source

Small GTPases and phosphoinositides in the regulatory mechanisms of macropinosome formation and maturation

Frontiers in Physiology, 2014
Macropinosome formation requires the sequential activation of numerous signaling pathways that coordinate the actin-driven formation of plasma membrane protrusions (ruffles) and circular ruffles (macropinocytic cups), followed by the closure of these ...
Youhei eEgami, Tomohiko eTaguchi, Tomohiko eTaguchi, Masashi eMaekawa, Masashi eMaekawa, Hiroyuki eArai, Hiroyuki eArai, Nobukazu eAraki   +7 more
doaj   +1 more source

Phosphatidylinositol-3,4,5-Triphosphate and Cellular Signaling: Implications for Obesity and Diabetes

Cellular Physiology and Biochemistry, 2015
Phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) is one of the most important phosphoinositides and is capable of activating a wide range of proteins through its interaction with their specific binding domains.
Prasenjit Manna, Sushil K. Jain
doaj   +1 more source

The emerging role of phosphoinositide clustering in intracellular trafficking and signal transduction [version 1; referees: 4 approved]

F1000Research, 2016
Phosphoinositides are master regulators of multiple cellular processes: from vesicular trafficking to signaling, cytoskeleton dynamics, and cell growth.
Laura Picas, Frederique Gaits-Iacovoni, Bruno Goud   +2 more
doaj   +1 more source

Phosphatidylinositol 4,5-Bisphosphate Mediates the Co-Distribution of Influenza A Hemagglutinin and Matrix Protein M1 at the Plasma Membrane

Viruses, 2022
The fully assembled influenza A virus (IAV) has on its surface the highest density of a single membrane protein found in nature—the glycoprotein hemagglutinin (HA) that mediates viral binding, entry, and assembly.
Prakash Raut, Bright Obeng, Hang Waters, Joshua Zimmerberg, Julie A. Gosse, Samuel T. Hess   +5 more
doaj   +1 more source

Lipid dynamics at dendritic spines

Frontiers in Neuroanatomy, 2014
Dynamic changes in the structure and composition of the membrane protrusions forming dendritic spines underlie memory and learning processes. In recent years a great effort has been made to characterize in detail the protein machinery that controls spine
Carlos Gerardo Dotti, Jose Antonio Esteban, Maria Dolores eLedesma   +2 more
doaj   +1 more source

Targeting phosphoinositide signaling in cancer: relevant techniques to study lipids and novel avenues for therapeutic intervention

Frontiers in Cell and Developmental Biology, 2023
Phosphoinositides serve as essential players in numerous biological activities and are critical for overall cellular function. Due to their complex chemical structures, localization, and low abundance, current challenges in the phosphoinositide field ...
Alicia Llorente, Ryan M. Loughran, Brooke M. Emerling   +2 more
doaj   +1 more source

Phosphatidylinositolphosphate phosphatase activities and cancer

Journal of Lipid Research, 2016
Signaling through the phosphoinositide 3-kinase pathways mediates the actions of a plethora of hormones, growth factors, cytokines, and neurotransmitters upon their target cells following receptor occupation.
Simon A. Rudge, Michael J.O. Wakelam
doaj   +1 more source

Phosphoinositide-signaling is one component of a robust plant defense response.

Frontiers in Plant Science, 2014
The phosphoinositide pathway and inositol-1,4,5-triphosphate (InsP3) have been implicated in plant responses to many abiotic stresses; however, their role in response to biotic stress is not well characterized.
Imara Yasmin Perera, Chiu-Yueh eHung, Peter eAspesi Jr, Melissa R Hunter, Aaron eLomax   +4 more
doaj   +1 more source

Taurine Attenuates Streptococcus uberis-Induced Bovine Mammary Epithelial Cells Inflammation via Phosphoinositides/Ca2+ Signaling

Frontiers in Immunology, 2019
Taurine may alleviate the inflammatory injury induced by Streptococcus uberis (S. uberis) infection by regulating intracellular Ca2+ levels. However, the underlying mechanisms remain unclear. Infection leads to subversion of phosphoinositides (PIs) which
Ming Li, Panpan Xi, Yuanyuan Xu, Zhenglei Wang, Xiangan Han, Wenkai Ren, Vanhnaseng Phouthapane, Jinfeng Miao   +7 more
doaj   +1 more source