Results 1 to 10 of about 97,335 (259)
Calmodulin Activates Phosphatidylinositol 3-Kinase [PDF]
Journal of Biological Chemistry, 1997 Calmodulin and phosphatidylinositol 3-kinase are vital components of a number of common intracellular events. Calmodulin, a ubiquitous Ca2+-dependent effector protein, regulates multiple processes in eukaryotic cells, including cytoskeletal organization, vesicular trafficking, and mitogenesis.
J L, Joyal +6 more
openaire +2 more sources
Phosphatidylinositol 3-Kinase [PDF]
Circulation Research, 2002 The pathogenesis of essential hypertension is multifactorial. Although the cause of elevated arterial pressure is unknown in most cases, the fundamental hemodynamic abnormality in hypertension is increased peripheral resistance primarily due to changes in vascular structure and function.1 These changes include arterial wall thickening and abnormal ...
Masataka, Sata, Ryozo, Nagai
openaire +2 more sources
The spatial distribution of GPCR and Gβγ activity across a cell dictates PIP3 dynamics
Scientific Reports, 2023 Phosphatidylinositol (3,4,5) trisphosphate (PIP3) is a plasma membrane-bound signaling phospholipid involved in many cellular signaling pathways that control crucial cellular processes and behaviors, including cytoskeleton remodeling, metabolism ...
Dhanushan Wijayaratna +5 more
doaj +1 more source
Targeting PI3K in cancer: any good news?
Frontiers in Oncology, 2013 The phosphatidylinositol 3-kinase (PI3K) signaling pathway regulates several cellular processes and it’s one of the most frequently deregulated pathway in human tumors.
Miriam eMartini +3 more
doaj +1 more source
Class I phosphatidylinositol 3-kinase inhibitors for cancer therapy
Acta Pharmaceutica Sinica B, 2017 The phosphatidylinositol 3-kinase (PI3K) pathway is frequently activated in human cancers. Class I PI3Ks are lipid kinases that phosphorylate phosphatidylinositol 4,5-bisphosphate (PIP2) at the 3-OH of the inositol ring to generate phosphatidylinositol 3,
Wennan Zhao, Yuling Qiu, Dexin Kong
doaj +1 more source
BMC Cancer, 2023 Background There is pressing needs to find the biomarker in the selection of neoadjuvant therapy in postmenopausal luminal breast cancer patients. We examined the hypothesis that PIK3CA mutations and low phosphatase and tensin homolog (PTEN) expression ...
Shouko Hayama +14 more
doaj +1 more source
Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ
Nature Communications, 2017 Phosphatidylinositol-3-kinases (PI3K) γ and δ are key regulators of T cell signaling. Here the author show, using mouse heart allograft transplantation models, that PI3Kγ or PI3Kδ deficiency prolongs graft survival, but selective inhibition of PI3Kγ or ...
Mayuko Uehara +14 more
doaj +1 more source
Frontiers in Plant Science, 2016 Wortmannin, a fungal metabolite and an inhibitor of phosphatidylinositol-3 (PI3) and phosphatidylinositol-4 (PI4) kinases, is widely used for the investigation and dissection of vacuolar trafficking routes and for the identification of proteins located ...
Ilse eFoissner +4 more
doaj +1 more source
Dedifferentiation of adenocarcinomas by activation of phosphatidylinositol 3-kinase [PDF]
Proceedings of the National Academy of Sciences, 1999 Signet ring cell carcinoma is a malignant type of poorly differentiated adenocarcinomas in stomach, which is characterized by the occasional presence of signet ring-like cancer cells. We found that expression of constitutively active phosphatidylinositol 3-kinase (PI 3-kinase) in well differentiated adenocarcinoma cell lines induced the loss of cell ...
M, Kobayashi +7 more
openaire +2 more sources
Phosphatidylinositol 3-kinases and their roles in phagosome maturation [PDF]
Journal of Leukocyte Biology, 2012 Abstract Review on how PI3Ks regulate phagosome maturation downstream of different phagocytic receptors, and their involvement in Rab activation and Ca2+ signaling. Phagosome maturation is a highly organized and sequential process that results in the formation of a microbicidal phagolysosome.
Emily P, Thi, Neil E, Reiner
openaire +2 more sources