Results 11 to 20 of about 18,384,661 (291)
Multiple phosphatidylinositol 3-kinases regulate vaccinia virus morphogenesis. [PDF]
PLoS ONE, 2010 Poxvirus morphogenesis is a complex process that involves the successive wrapping of the virus in host cell membranes. We screened by plaque assay a focused library of kinase inhibitors for those that caused a reduction in viral growth and identified ...
Shannon McNulty +9 more
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Inhibitors of phosphatidylinositol 3'-kinases promote mitotic cell death in HeLa cells. [PDF]
PLoS ONE, 2012 The phosphatidylinositol 3-kinase (PI3K) pathway plays an important role in many biological processes, including cell cycle progression, cell growth, survival, actin rearrangement and migration, and intracellular vesicular transport.
Heli Hou +8 more
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Lipid kinases PIP5Ks and PIP4Ks: potential drug targets for breast cancer
Frontiers in Oncology, 2023 Phosphoinositides, a small group of lipids found in all cellular membranes, have recently garnered heightened attention due to their crucial roles in diverse biological processes and different diseases. Among these, phosphatidylinositol 4,5-bisphosphate (
Yue Jin, Jian Xue
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Phosphatidylinositol kinases in GtoPdb v.2021.3 [PDF]
, 2021 Phosphatidylinositol may be phosphorylated at either 3- or 4- positions on the inositol ring by PI 3-kinases or PI 4-kinases, respectively.Phosphatidylinositol 3-kinasesPhosphatidylinositol 3-kinases (PI3K, provisional nomenclature) catalyse the ...
Uddin, Mohib
core +1 more source
Phosphatidylinositol kinases in GtoPdb v.2023.1 [PDF]
, 2023 Phosphatidylinositol may be phosphorylated at either 3- or 4- positions on the inositol ring by PI 3-kinases or PI 4-kinases, respectively.Phosphatidylinositol 3-kinasesPhosphatidylinositol 3-kinases (PI3K, provisional nomenclature) catalyse the ...
Uddin, Mohib, Mohib Uddin
core +1 more source
Frontiers in Pharmacology, 2021 Phenazopyridine is a widely used drug against urinary tract pain. The compound has also been shown to enhance neural differentiation of pluripotent stem cells. However, its mechanism of action is not understood.
Olivier Preynat-Seauve +11 more
doaj +1 more source
Gene amplifications associated with the development of hormone- resistant prostate cancer [PDF]
, 2003 Purpose: Hormone resistance remains a significant clinical problem in prostate cancer with few therapeutic options. Research into mechanisms of hormone resistance is essential.
Krishnan, S. +3 more
core +8 more sources
Phosphatidylinositol 3-Kinase [PDF]
Pancreas, 2016 Even though a strong association between inflammation and cancer has been widely accepted, the underlying precise molecular mechanisms are still largely unknown. A complex signaling network between tumor and stromal cells is responsible for the infiltration of inflammatory cells into the cancer microenvironment.
Birtolo, Chiara +4 more
+7 more sources
Identification of Key Phospholipids That Bind and Activate Atypical PKCs
Biomedicines, 2021 PKCζ and PKCι/λ form the atypical protein kinase C subgroup, characterised by a lack of regulation by calcium and the neutral lipid diacylglycerol. To better understand the regulation of these kinases, we systematically explored their interactions with ...
Suresh Velnati +10 more
doaj +1 more source
Vps34 is a phosphatidylinositol 3-kinase, not a phosphoinositide 3-kinase [PDF]
Autophagy, 2011 There seems to be some confusion regarding the naming of enzymes that phosphorylate certain lipids. In particular, we are referring to the lipid phosphatidylinositol and to phosphoinositides. Inositides are inositol-containing derivatives of phosphatidic acid (Fig. 1).
Meijer, A.J., Klionsky, D.J.
openaire +4 more sources