Results 11 to 20 of about 97,335 (259)
Multiple phosphatidylinositol 3-kinases regulate vaccinia virus morphogenesis. [PDF]
PLoS ONE, 2010 Poxvirus morphogenesis is a complex process that involves the successive wrapping of the virus in host cell membranes. We screened by plaque assay a focused library of kinase inhibitors for those that caused a reduction in viral growth and identified ...
Shannon McNulty +9 more
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Inhibitors of phosphatidylinositol 3'-kinases promote mitotic cell death in HeLa cells. [PDF]
PLoS ONE, 2012 The phosphatidylinositol 3-kinase (PI3K) pathway plays an important role in many biological processes, including cell cycle progression, cell growth, survival, actin rearrangement and migration, and intracellular vesicular transport.
Heli Hou +8 more
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Simultaneous inhibition of pan-phosphatidylinositol-3-kinases and MEK as a potential therapeutic strategy in peripheral T-cell lymphomas [PDF]
Haematologica, 2013 Peripheral T-cell lymphomas are very aggressive hematologic malignancies for which there is no targeted therapy. New, rational approaches are necessary to improve the very poor outcome in these patients.
Esperanza Martín-Sánchez +19 more
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Lipid kinases PIP5Ks and PIP4Ks: potential drug targets for breast cancer
Frontiers in Oncology, 2023 Phosphoinositides, a small group of lipids found in all cellular membranes, have recently garnered heightened attention due to their crucial roles in diverse biological processes and different diseases. Among these, phosphatidylinositol 4,5-bisphosphate (
Yue Jin, Jian Xue
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Frontiers in Pharmacology, 2021 Phenazopyridine is a widely used drug against urinary tract pain. The compound has also been shown to enhance neural differentiation of pluripotent stem cells. However, its mechanism of action is not understood.
Olivier Preynat-Seauve +11 more
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Vps34 is a phosphatidylinositol 3-kinase, not a phosphoinositide 3-kinase [PDF]
Autophagy, 2011 There seems to be some confusion regarding the naming of enzymes that phosphorylate certain lipids. In particular, we are referring to the lipid phosphatidylinositol and to phosphoinositides. Inositides are inositol-containing derivatives of phosphatidic acid (Fig. 1).
Meijer, A.J., Klionsky, D.J.
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Phosphatidylinositol 3-Kinase [PDF]
Pancreas, 2016 Even though a strong association between inflammation and cancer has been widely accepted, the underlying precise molecular mechanisms are still largely unknown. A complex signaling network between tumor and stromal cells is responsible for the infiltration of inflammatory cells into the cancer microenvironment.
Birtolo, Chiara +4 more
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Phosphatidylinositol 3‐kinases in tumor progression [PDF]
European Journal of Biochemistry, 2001 Many cellular processes have been identified in which phosphatidylinositol 3‐kinase has a key regulatory function. As an oncogene, it is also involved in the development of cancer. The transformation and progression of normal cells towards an advanced stage tumor and/or towards metastatic lesions involves a complex series of events, including genetic ...
Roymans, D., Slegers, H.
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Identification of Key Phospholipids That Bind and Activate Atypical PKCs
Biomedicines, 2021 PKCζ and PKCι/λ form the atypical protein kinase C subgroup, characterised by a lack of regulation by calcium and the neutral lipid diacylglycerol. To better understand the regulation of these kinases, we systematically explored their interactions with ...
Suresh Velnati +10 more
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Phosphatidylinositol 3-Kinase: The Oncoprotein [PDF]
, 2010 The catalytic and regulatory subunits of class I phosphoinositide 3-kinase (PI3K) have oncogenic potential. The catalytic subunit p110α and the regulatory subunit p85 undergo cancer-specific gain-of-function mutations that lead to enhanced enzymatic activity, ability to signal constitutively, and oncogenicity.
Peter K, Vogt +7 more
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