Results 1 to 10 of about 75,650 (115)

Selective phosphoinositide 3-kinase inhibitors and implication in diabetic retinopathy as pharmacological tools [PDF]

Frontiers in Pharmacology
Phosphoinositide 3-kinases (PI3Ks) are ubiquitous enzymes, that regulate different cellular functions, most involved in pathogenesis and progression of several oncological diseases.
Carmela Bonaccorso, Francesca Lazzara, Francesca Lazzara, Francesca Lazzara, Isabel La Rosa, Cristina Munzone, Alessandro Grasso, Chiara B. M. Platania, Chiara B. M. Platania, Claudio Bucolo, Claudio Bucolo   +10 more
doaj   +2 more sources

Identification of Novel Thiazolo[5,4-b]Pyridine Derivatives as Potent Phosphoinositide 3-Kinase Inhibitors [PDF]

Molecules, 2020
A series of novel 2-pyridyl, 4-morpholinyl substituted thiazolo[5,4-b]pyridine analogues have been designed and synthesized in this paper. These thiazolo[5,4-b]pyridines were efficiently prepared in seven steps from commercially available substances in ...
Liang Xia, Yan Zhang, Jingbo Zhang, Songwen Lin, Kehui Zhang, Hua Tian, Yi Dong, Heng Xu   +7 more
doaj   +2 more sources

Effects of novel isoform-selective phosphoinositide 3-kinase inhibitors on natural killer cell function. [PDF]

PLoS ONE, 2014
Phosphoinositide 3-kinases (PI3Ks) are promising targets for therapeutic development in cancer. The class I PI3K isoform p110α has received considerable attention in oncology because the gene encoding p110α (PIK3CA) is frequently mutated in human cancer.
Sung Su Yea, Lomon So, Sharmila Mallya, Jongdae Lee, Kamalakannan Rajasekaran, Subramaniam Malarkannan, David A Fruman   +6 more
doaj   +2 more sources

Phosphoinositide 3-kinase inhibitors are effective therapeutic drugs for the treatment of hepatocellular carcinoma? [PDF]

Clinical and Molecular Hepatology, 2020
Jeong Su Park, Soo Han Bae
doaj   +2 more sources

Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2016
John M Asara, Evan C Lien, Gerburg M Wulf   +2 more
exaly   +2 more sources

Inhibitors of phosphoinositide 3-kinase (PI3K) and phosphoinositide 3-kinase-related protein kinase family (PIKK)

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Phosphoinositide 3-kinases (PI3K) and phosphoinositide 3-kinase-related protein kinases (PIKK) are two structurally related families of kinases that play vital roles in cell growth and DNA damage repair.
Xueqin Huang, Li You, Eugenie Nepovimova, Miroslav Psotka, David Malinak, Marian Valko, Ladislav Sivak, Jan Korabecny, Zbynek Heger, Vojtech Adam, Qinghua Wu, Kamil Kuca   +11 more
doaj   +1 more source

Serum and glucocorticoid-regulated kinase 1: Structure, biological functions, and its inhibitors

Frontiers in Pharmacology, 2022
Serum and glucocorticoid-regulated kinase 1 (SGK1) is a serine/threonine kinase belonging to the protein kinase A, G, and C (AGC) family. Upon initiation of the phosphoinositide 3-kinase (PI3K) signaling pathway, mammalian target of rapamycin complex 2 ...
Hyunsoo Jang, Youngjun Park, Youngjun Park, Jaebong Jang   +3 more
doaj   +1 more source

Leveraging molecular structure and bioactivity with chemical language models for de novo drug design

Nature Communications, 2023
Generative Deep Learning holds promise for mining the unexplored “chemical universe” for new drugs. Here, the authors demonstrate the de novo design of phosphoinositide 3-kinase gamma (PI3Kγ) inhibitors for the PI3K/Akt pathway in human tumor cells.
Michael Moret, Irene Pachon Angona, Leandro Cotos, Shen Yan, Kenneth Atz, Cyrill Brunner, Martin Baumgartner, Francesca Grisoni, Gisbert Schneider   +8 more
doaj   +1 more source

An updated review on activated PI3 kinase delta syndrome (APDS)

Genes and Diseases, 2020
Activated Phosphoinositide 3-kinase δ syndrome (APDS) is a newly recognised primary immunodeficiency disease. It has currently been a hot topic of clinical research and new data are emerging regarding its pathogenesis, clinical manifestations and ...
Ankita Singh, Vibhu Joshi, Ankur Kumar Jindal, Babu Mathew, Amit Rawat   +4 more
doaj   +1 more source

Identification of novel piperazinylquinoxaline derivatives as potent phosphoinositide 3-kinase (PI3K) inhibitors. [PDF]

PLoS ONE, 2012
Development of small-molecule inhibitors targeting phosphoinositide 3-kinase (PI3K) has been an appealing strategy for the treatment of various types of cancers.Our approach was to perform structural modification and optimization based on previously ...
Peng Wu, Yi Su, Xianghong Guan, Xiaowen Liu, Jiankang Zhang, Xiaowu Dong, Wenhai Huang, Yongzhou Hu   +7 more
doaj   +1 more source