Results 41 to 50 of about 219,778 (281)
eLife, 2021 Class I Phosphoinositide 3-kinases (PI3Ks) are master regulators of cellular functions, with the class IB PI3K catalytic subunit (p110γ) playing key roles in immune signalling.
Manoj K Rathinaswamy +8 more
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Therapeutic potential of phosphoinositide 3-kinase inhibitors in rheumatoid arthritis
Japanese Journal of Clinical Immunology, 2007 Activation of PI3K is a key step of intracellular signaling involved in many cellular functions. PI3K inhibitors have shown anti-rheumatic effects on arthritis model in mice. PI3K is a potential therapeutic target of rheumatoid arthritis.
TAMURA, Naoto, HARUTA, Kazuhiko
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Immunotherapy in breast cancer: A clinician's perspective
Journal of the National Cancer Center, 2021 Globally over 2 million women are diagnosed with breast cancer each year despite major advances in detection and treatment of the disease. Breast cancer is comprised of several distinct subtypes and understanding the heterogeneity of the disease has ...
Sibapriya Chaudhuri +2 more
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Targeted delivery of a phosphoinositide 3‐kinase γ inhibitor to restore organ function in sepsis [PDF]
EMBO Molecular Medicine, 2021 Jaundice, the clinical hallmark of infection-associated liver dysfunction, reflects altered membrane organization of the canalicular pole of hepatocytes and portends poor outcomes. Mice lacking phosphoinositide 3-kinase-γ (PI3Kγ) are protected against membrane disintegration and hepatic excretory dysfunction.
Adrian T Press +19 more
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Targeted treatment of vascular anomalies
International Journal of Women's Dermatology, 2021 Vascular anomalies comprise an array of congenital developmental disorders that can lead to significant disfigurement and physiologic disarray. The vast multitude of clinical phenotypes has inherently led to misdiagnosis and patients and families ...
Ashley T. Ng, BS +2 more
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Frontiers in Antibiotics, 2023 The rise in antimicrobial resistance and the decline in new antibiotics has created a great need for novel approaches to treat drug resistant bacterial infections. Increasing the burden of antimicrobial resistance, bacterial virulence factors allow for survival within the host, where they can evade host killing and antimicrobial therapy within their ...
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Biomolecules, 2019 The hyper-activation of the phosphoinositide (PI) 3-kinase signaling pathway is a hallmark of many cancers and overgrowth syndromes, and as a result, there has been intense interest in the development of drugs that target the various isoforms of PI 3 ...
Christina M. Buchanan +2 more
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Targeting Phosphoinositide 3-Kinase – Five Decades of Chemical Space Exploration
CHIMIA, 2021 Phosphoinositide 3-kinase (PI3K) takes a key role in a plethora of physiologic processes and controls cell growth, metabolism, immunity, cardiovascular and neurological function, and more.
Chiara Borsari, Matthias P. Wymann
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Inositol Polyphosphate-Based Compounds as Inhibitors of Phosphoinositide 3-Kinase-Dependent Signaling [PDF]
International Journal of Molecular Sciences, 2020 Signaling pathways regulated by the phosphoinositide 3-kinase (PI3K) enzymes have a well-established role in cancer development and progression. Over the past 30 years, the therapeutic potential of targeting this pathway has been well recognized, and this has led to the development of a multitude of drugs, some of which have progressed into clinical ...
Tania Maffucci, Marco Falasca
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Frontiers in Cellular Neuroscience, 2013 In cells cultured from neocortex of newborn rats, phosphoinositide-3-kinases of class I regulate the DNA synthesis in a subgroup of astroglial cells. We have studied the location of these cells as well as the kinase isoforms which facilitate the S phase ...
Rabea eMüller +6 more
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