Magic power of phosphoinositide 3-kinase inhibitors
Molecular and Cellular Therapies, 2017 Phosphoinositide 3-kinases (PI3K) play critical roles in the maintenance of cell biological functions and are suggested as a therapeutic target for drug discovery and development.
Xiangdong Wang
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Effects of novel isoform-selective phosphoinositide 3-kinase inhibitors on natural killer cell function. [PDF]
PLoS ONE, 2014 Phosphoinositide 3-kinases (PI3Ks) are promising targets for therapeutic development in cancer. The class I PI3K isoform p110α has received considerable attention in oncology because the gene encoding p110α (PIK3CA) is frequently mutated in human cancer.
Sung Su Yea +6 more
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Antithrombotic phosphoinositide 3‐kinase β inhibitors in humans: a ‘shear’ delight! [PDF]
Journal of Thrombosis and Haemostasis, 2012 Jackson SP, Schoenwaelder SM. Antithrombotic phosphoinositide 3-kinase β inhibitors in humans: a ‘shear’ delight!J Thromb Haemost 2012; 10: 2123–6.See also Nylander S, Kull B, Bjorkman JA, Ulvinge J-C, Oakes N, Emanuelsson BM, Andersson M, Skarby T, Inghardt T, Fjellstrom O, Gustafsson D.
Shaun P. Jackson, S. Schoenwaelder
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Journal of Cell Biology, 1999 The architectural complexity of the hepatocyte canalicular surface has prevented examination of apical membrane dynamics with methods used for other epithelial cells.
A L Hubbard, Hubbard Ann L
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Identification of novel piperazinylquinoxaline derivatives as potent phosphoinositide 3-kinase (PI3K) inhibitors. [PDF]
PLoS ONE, 2012 Development of small-molecule inhibitors targeting phosphoinositide 3-kinase (PI3K) has been an appealing strategy for the treatment of various types of cancers.Our approach was to perform structural modification and optimization based on previously ...
Peng Wu +7 more
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Targeting Melanoma with Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitors [PDF]
Molecular Cancer Research, 2009 Phosphoinositide 3-kinase (PI3K)/protein kinase B/Akt and Ras/mitogen-activated protein kinase pathways are often constitutively activated in melanoma and have thus been considered as promising drug targets.
Romina Marone +10 more
semanticscholar +4 more sources
Phosphoinositide 3-kinase inhibitors are effective therapeutic drugs for the treatment of hepatocellular carcinoma? [PDF]
Clinical and Molecular Hepatology, 2020 Jeong Su Park, Soo Han Bae
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Serum and glucocorticoid-regulated kinase 1: Structure, biological functions, and its inhibitors
Frontiers in Pharmacology, 2022 Serum and glucocorticoid-regulated kinase 1 (SGK1) is a serine/threonine kinase belonging to the protein kinase A, G, and C (AGC) family. Upon initiation of the phosphoinositide 3-kinase (PI3K) signaling pathway, mammalian target of rapamycin complex 2 ...
Hyunsoo Jang +3 more
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Resveratrol is a class IA phosphoinositide 3-kinase inhibitor [PDF]
Biochemical Journal, 2007 Resveratrol, a polyphenol found in fruits, possesses chemopreventive and chemotherapeutic properties and has been shown to increase lifespan in yeast and metazoans, including mice. Genetic evidence and in vitro enzymatic measurements indicate that the deacetylase Sir2/SIRT1, an enzyme promoting stress resistance and aging, is the target of resveratrol.
Fröjdö, Sara +3 more
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Leveraging molecular structure and bioactivity with chemical language models for de novo drug design
Nature Communications, 2023 Generative Deep Learning holds promise for mining the unexplored “chemical universe” for new drugs. Here, the authors demonstrate the de novo design of phosphoinositide 3-kinase gamma (PI3Kγ) inhibitors for the PI3K/Akt pathway in human tumor cells.
Michael Moret +8 more
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