Results 31 to 40 of about 19,152,238 (244)

Regulation of protein kinase B (PKB/Akt) by DNA-dependent protein kinase (DNA-PK) under physiological conditions [PDF]

, 2010
The serine/threonine protein kinase B (PKB/Akt) is a downstream effector of phosphatidylinositol 3-kinase (PI3K) and a major regulator of a variety of cellular processes, including metabolism, transcription, survival, proliferation, and growth.
Sürücü, Banu
core   +1 more source

For Better or Worse: The Potential for Dose Limiting the On-Target Toxicity of PI 3-Kinase Inhibitors

Biomolecules, 2019
The hyper-activation of the phosphoinositide (PI) 3-kinase signaling pathway is a hallmark of many cancers and overgrowth syndromes, and as a result, there has been intense interest in the development of drugs that target the various isoforms of PI 3 ...
Christina M. Buchanan, Kate L. Lee, Peter R. Shepherd   +2 more
doaj   +1 more source

Targeting Phosphoinositide 3-Kinase – Five Decades of Chemical Space Exploration

CHIMIA, 2021
Phosphoinositide 3-kinase (PI3K) takes a key role in a plethora of physiologic processes and controls cell growth, metabolism, immunity, cardiovascular and neurological function, and more.
Chiara Borsari, Matthias P. Wymann
doaj   +1 more source

Combinatorial strategy using protein kinase inhibitors and a cytotoxic compound for highly resistant glioblastoma cells : "in vitro studies" [PDF]

, 2007
Glioblastoma multiforme (GBM) is the most frequent and the most aggesssive malignant neoplasm of the human central nervous system (CNS), with a median survival of less than one year. These neoplasms are radio- and chemo-resistant, and are highly invasive,
Failly, Mike
core   +1 more source

Phosphoinositide-3-kinases p110alpha and p110beta mediate S phase entry in astroglial cells in the marginal zone of rat neocortex

Frontiers in Cellular Neuroscience, 2013
In cells cultured from neocortex of newborn rats, phosphoinositide-3-kinases of class I regulate the DNA synthesis in a subgroup of astroglial cells. We have studied the location of these cells as well as the kinase isoforms which facilitate the S phase ...
Rabea eMüller, Catharina eFischer, Thomas eWilmes, Bernd eHeimrich, Vanessa eDistel, Norbert eKlugbauer, Dieter Klaus Meyer   +6 more
doaj   +1 more source

Acanthamoeba castellanii induces host cell death via a phosphatidylinositol 3-kinase-dependent mechanism [PDF]

, 2005
Granulomatous amoebic encephalitis due to Acanthamoeba castellanii is a serious human infection with fatal consequences, but it is not clear how the circulating amoebae interact with the blood-brain barrier and transmigrate into the central nervous ...
S. Jayasekera, N. A. Khan, M. Stins, K. S. Kim, Alsam, S., Stins, M., Khan, Naveed Ahmed, Sissons, J., J. Sissons, Kim, K.S., Jayasekera, S., S. Alsam   +11 more
core   +1 more source

The Role of PI3K Inhibition in the Treatment of Breast Cancer, Alone or Combined With Immune Checkpoint Inhibitors

Frontiers in Molecular Biosciences, 2021
Dysregulation of phosphoinositide 3-kinase (PI3K) signaling is highly implicated in tumorigenesis, disease progression, and the development of resistance to the current standard of care treatments in breast cancer patients. This review discusses the role
Zhizhu Zhang, Ann Richmond, Ann Richmond
doaj   +1 more source

Activation of Phosphoinositide 3-Kinase, Protein Kinase C, and Extracellular Signal-Regulated Kinase Is Required for Oridonin-Enhanced Phagocytosis of Apoptotic Bodies in Human Macrophage-Like U937 Cells

Journal of Pharmacological Sciences, 2005
Our previous study showed that oridonin isolated from Rabdosia rubescens enhanced phagocytosis of apoptotic cells by macrophage-like U937 cells through tumor necrosis factor (TNF) α and interleukin (IL)-1β release.
Yan-Qiu Liu, Song You, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima   +4 more
doaj   +1 more source

3-Phosphoinositide-dependent protein kinase-1 as an emerging target in the management of breast cancer

, 2013
Chanse Fyffe, Marco Falasca Queen Mary University of London, Barts and The London School of Medicine and Dentistry, Blizard Institute, Inositide Signallling Group, London, UK Abstract: It should be noted that 3-phosphoinositide-dependent protein kinase-1
Falasca M, Fyffe C
core   +2 more sources

Preclinical validation of 3-phosphoinositide-dependent protein kinase 1 inhibition in pancreatic cancer

Journal of Experimental & Clinical Cancer Research, 2019
Background The very aggressive nature and low survival rate of pancreatic ductal adenocarcinoma (PDAC) dictates the necessity to find novel efficacious therapies.
Aikaterini Emmanouilidi, Chanse A. Fyffe, Riccardo Ferro, Charlotte E. Edling, Emily Capone, Simona Sestito, Simona Rapposelli, Rossano Lattanzio, Stefano Iacobelli, Gianluca Sala, Tania Maffucci, Marco Falasca   +11 more
doaj   +1 more source