Results 1 to 10 of about 2,078,396 (299)

Properties of FDA-approved small molecule protein kinase inhibitors: a 2024 update.

Pharmacological Research
Owing to the dysregulation of protein kinase activity in many diseases including cancer, this enzyme family has become one of the most important drug targets in the 21st century.
R. Roskoski
semanticscholar   +1 more source

Pulmonary arterial hypertension associated with protein kinase inhibitors: a pharmacovigilance–pharmacodynamic study

European Respiratory Journal, 2019
The pathophysiology of pulmonary arterial hypertension (PAH) induced by protein kinase inhibitors (PKIs) remains unclear. To gain knowledge into this rare and severe pathology we performed a study combining a pharmacovigilance approach and the ...
Lucie Cornet, C. Khouri, M. Roustit, C. Guignabert, M. Chaumais, M. Humbert, B. Revol, F. Despas, D. Montani, J. Cracowski   +9 more
semanticscholar   +1 more source

Compounds from Natural Sources as Protein Kinase Inhibitors

Biomolecules, 2020
The advantage of natural compounds is their lower number of side-effects when compared to most synthetic substances. Therefore, over the past several decades, the interest in naturally occurring compounds is increasing in the search for new potent drugs.
Andrea Baier, Ryszard Szyszka
doaj   +1 more source

Kinome-wide interaction modelling using alignment-based and alignment-independent approaches for kinase description and linear and non-linear data analysis techniques

BMC Bioinformatics, 2010
Background Protein kinases play crucial roles in cell growth, differentiation, and apoptosis. Abnormal function of protein kinases can lead to many serious diseases, such as cancer.
Wikberg Jarl ES, Lapins Maris
doaj   +1 more source

Extracellular Signal-Regulated Kinase (ERK) Inhibitors in Oncology Clinical Trials [PDF]

Journal of Immunotherapy and Precision Oncology, 2019
The mitogen-activated protein kinase (MAPK) pathway consists of the series of protein kinases RAS-RAF-MEK- Extracellular signal-regulated kinase (ERK), and its function is important to cell proliferation, differentiation, motility, and survival.
Haelee M Chin, David K Lai, Gerald S Falchook   +2 more
doaj   +1 more source

Exploring the chemotherapeutic potential of currently used kinase inhibitors: An update

Frontiers in Pharmacology, 2023
Protein kinases are enzymes that transfer phosphate to protein, resulting in the modification of the protein. The human genome encodes approximately 538 kinases.
Rajashri R. Naik, Ashok K. Shakya
doaj   +1 more source

New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors

bioRxiv, 2018
Protein tyrosine sulphation is a post-translational modification (PTM) best known for regulating extracellular protein-protein interactions. Tyrosine sulphation is catalysed by two Golgi-resident enzymes termed Tyrosyl Protein Sulpho Transferases (TPSTs)
D. Byrne, Yong Li, Pawin Ngamlert, Krithika Ramakrishnan, C. Eyers, C. Wells, D. Drewry, W. Zuercher, N. Berry, D. Fernig, P. Eyers   +10 more
semanticscholar   +1 more source

Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target

Nature reviews. Drug discovery, 2020
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a key mediator of cell death and inflammation. The unique hydrophobic pocket in the allosteric regulatory domain of RIPK1 has enabled the development of highly selective small-molecule ...
Lauren Mifflin, D. Ofengeim, Junying Yuan   +2 more
semanticscholar   +1 more source

Targeting autophagy-related protein kinases for potential therapeutic purpose

Acta Pharmaceutica Sinica B, 2020
Autophagy, defined as a scavenging process of protein aggregates and damaged organelles mediated by lysosomes, plays a significant role in the quality control of macromolecules and organelles.
Honggang Xiang, Jifa Zhang, Congcong Lin, Lan Zhang, Bo Liu, Liang Ouyang   +5 more
doaj   +1 more source

Identification of Novel Cdc7 Kinase Inhibitors as Anti-Cancer Agents that Target the Interaction with Dbf4 by the Fragment Complementation and Drug Repositioning ApproachResearch in context

EBioMedicine, 2018
Background: Cdc7-Dbf4 is a conserved serine/threonine kinase that plays an important role in initiation of DNA replication and DNA damage tolerance in eukaryotic cells.
An Ning Cheng, Yu-Kang Lo, Yi-Sheng Lin, Tswen-Kei Tang, Chun-Hua Hsu, John T.-A. Hsu, Alan Yueh-Luen Lee   +6 more
doaj   +1 more source