Results 41 to 50 of about 4,627,885 (297)

Targeting sphingosine kinase 1 in carcinoma cells decreases proliferation and survival by compromising PKC activity and cytokinesis [PDF]

, 2012
Sphingosine kinases (SK) catalyze the phosphorylation of proapoptotic sphingosine to the prosurvival factor sphingosine 1-phosphate (S1P), thereby promoting oncogenic processes.
Zangemeister-Wittke, Uwe, Fabbro, Doriano, Doriano Fabbro, Huwiler Andrea, Zangemeister-Wittke Uwe, Huwiler, Andrea, Uwe Zangemeister-Wittke, Kotelevets Nataliya, Nataliya Kotelevets (156133), Kotelevets, Nataliya, Nataliya Kotelevets, Andrea Huwiler, Doriano Fabbro (156139), Andrea Huwiler (156145), Uwe Zangemeister-Wittke (156150), Fabbro Doriano   +15 more
core   +2 more sources

Flavopiridol Protects Against Inflammation by Attenuating Leukocyte-Endothelial Interaction via Inhibition of Cyclin-Dependent Kinase 9 [PDF]

, 2011
Objective: The cyclin-dependent kinase (CDK) inhibitor flavopiridol is currently being tested in clinical trials as anticancer drug. Beyond its cell death–inducing action, we hypothesized that flavopiridol affects inflammatory processes.
Mayer, Bettina A., Nina Berberich, Stefan Zahler, Sass, Gabriele, Fritz Krombach, Vollmar, Angelika M., Tiegs, Gisa, Krombach, Fritz, Fürst, Robert, Robert Fürst, Totzke, Frank, Angelika M. Vollmar, Jos Joore, Gisa Tiegs, Berberich, Nina, Alexander G. Khandoga, Bettina A. Mayer, Joore, Jos, Ulrike K. Schmerwitz, Gabriele Sass, Zahler, Stefan, Frank Totzke, Schmerwitz, Ulrike K., Khandoga, Alexander G.   +23 more
core   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Selective anticancer activity of a hexapeptide with sequence homology to a non-kinase domain of Cyclin Dependent Kinase 4 [PDF]

, 2011
Background: cyclin-dependent kinases 2, 4 and 6 (Cdk2, Cdk4, Cdk6) are closely structurally homologous proteins which are classically understood to control the transition from the G1 to the S-phases of the cell cycle by combining with their appropriate ...
Maurer, RI, Jon W Essex, Warenius Hilmar M, Kilburn, Jeremy D., Richard I Maurer, Seabra, LA, Usha Agarwala, Laurence A Seabra, Warenius, Hilmar M., Warenius, HM, Blaydes, JP, Seabra Laurence A, Jeremy D Kilburn, Essex, JW, Agarwala, U, Essex Jon W, Agarwala, Usha, Blaydes Jeremy P, Essex, Jon W., Jeremy P Blaydes, Maurer, Richard I., Agarwala Usha, Seabra, Laurence A., Kilburn Jeremy D, Hilmar M Warenius, Blaydes, Jeremy P., Maurer Richard I, Kilburn, Jeremy D, Kilburn, JD   +28 more
core   +1 more source

Chemotherapy for Spinal Cord Intramedullary Pediatric Low‐Grade Glioma—A Systematic Literature Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko, Segev Gabay, Jonathan Roth, Amit Ringel, Rina Dvir, Shlomi Constantini   +5 more
wiley   +1 more source

Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress. [PDF]

, 2013
The malaria parasite replicates within an intraerythrocytic parasitophorous vacuole (PV). Eventually, in a tightly regulated process called egress, proteins of the PV and intracellular merozoite surface are modified by an essential parasite serine ...
Baker, David A, Strath Malcolm, Maria Penzo, David A Baker, Hackett Fiona, Penzo, Maria, Blackman, Michael J, Michael J Blackman, David A. Baker (122252), Christine R Collins, Fiona Hackett (27620), Christine R. Collins, Strath, Malcolm, Withers-Martinez, Chrislaine, David A. Baker, Michael J. Blackman, Malcolm Strath (411645), Withers-Martinez Chrislaine, Penzo Maria, Chrislaine Withers-Martinez, Malcolm Strath, Collins Christine R., Hackett, Fiona, Fiona Hackett, Chrislaine Withers-Martinez (27619), Baker David A., Collins, Christine R, Christine R. Collins (191982), Michael J. Blackman (192013), Blackman Michael J., Maria Penzo (411646)   +30 more
core   +1 more source

Compounds from Natural Sources as Protein Kinase Inhibitors

Biomolecules, 2020
The advantage of natural compounds is their lower number of side-effects when compared to most synthetic substances. Therefore, over the past several decades, the interest in naturally occurring compounds is increasing in the search for new potent drugs.
Andrea Baier, Ryszard Szyszka
doaj   +1 more source

Extracellular Signal-Regulated Kinase (ERK) Inhibitors in Oncology Clinical Trials [PDF]

Journal of Immunotherapy and Precision Oncology, 2019
The mitogen-activated protein kinase (MAPK) pathway consists of the series of protein kinases RAS-RAF-MEK- Extracellular signal-regulated kinase (ERK), and its function is important to cell proliferation, differentiation, motility, and survival.
Haelee M Chin, David K Lai, Gerald S Falchook   +2 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Ets-2 is a target for an Akt (protein kinase B)/Jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice [PDF]

, 2000
The transcription factor ets-2 was phosphorylated at residue threonine 72 in a colony-stimulating factor 1 (CSF-1)- and mitogen-activated protein kinase-independent manner in macrophages isolated from motheaten-viable (me-v) mice.
Forsthoefel, David, Ostrowski, M C, Hartman, M, Schaffner, A E, Smith, James L., Hume, D A, Smith, J L, Ostrowski, Michael C., Wei, G, Hofmeister, Joseph K., Hofmeister, J K, Schaffner, Alicia E., Wei, Guo, Hume, David A., Hartman, Matthew, Hartman, Matthew Hartman, Forsthoefel, D   +16 more
core   +1 more source