Results 31 to 40 of about 4,627,885 (297)

{alpha}2-Chimaerin, cyclin-dependent kinase 5/p35, and its target collapsin response mediator protein-2 are essential components in semaphorin 3A-induced growth-cone collapse [PDF]

, 2004
Neurite outgrowth is influenced by positive and negative signals that include the semaphorins, an important family of axonal outgrowth inhibitors. Here we report that the Rac GTPase activating protein (GAP){alpha}2-chimaerin is involved in Semaphorin 3A (
Eickholt, B, Teo, M, Lim, L, Ferrari, G, Eickholt, Britta, Jacobs, Tom, Leung, Thomas, Jacobs, T., Leung, T., Leung, T, Eickholt, B., Lim, L., Hall, Christine, Qi, R Z, Teo, M., Monfries, C, Jacobs, T, Brown, Matthew, Monfries, Clinton, Teo, Mabel, Qi, Robert Z., Ferrari, G., Qi, R.Z., Lim, Louis, Brown, M., Hall, C., Ferrari, Giovanna, Hall, C, Brown, M, Monfries, C.   +29 more
core   +1 more source

The Kinase Specificity of Protein Kinase Inhibitor Peptide [PDF]

Frontiers in Pharmacology, 2021
G-protein-coupled-receptor (GPCR) signaling is exquisitely controlled to achieve spatial and temporal specificity. The endogenous protein kinase inhibitor peptide (PKI) confines the spatial and temporal spread of the activity of protein kinase A (PKA), which integrates inputs from three major types of GPCRs.
Yao Chen, Yao Chen, Bernardo L. Sabatini
openaire   +4 more sources

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase [PDF]

, 2014
The Vps34 (vacuolar protein sorting 34) class III PI3K (phosphoinositide 3-kinase) phosphorylates PtdIns (phosphatidylinositol) at endosomal membranes to generate PtdIns(3)P that regulates membrane trafficking processes via its ability to recruit a ...
Ward, Richard, Davies, Paul; id_orcid, Bago, Ruzica, Shpiro, Natalia, Cross, Darren, Sommer, Eeva, Malik, Nazma, Ganley, Ian G.; id_orcid, Munson, Michael J., Alessi, Dario R.; id_orcid, Prescott, Alan R.; id_orcid   +10 more
core   +1 more source

Targeting mTOR for cancer therapy

Journal of Hematology & Oncology, 2019
Mechanistic target of rapamycin (mTOR) is a protein kinase regulating cell growth, survival, metabolism, and immunity. mTOR is usually assembled into several complexes such as mTOR complex 1/2 (mTORC1/2).
Hui Hua, Qingbin Kong, Hongying Zhang, Jiao Wang, Ting Luo, Yangfu Jiang   +5 more
doaj   +1 more source

Phosphoinositide-dependent protein kinase-1 (PDK1)-independent activation of the protein kinase C substrate, protein kinase D [PDF]

, 2007
Phosphoinoisitide dependent kinase l (PDK1) is proposed to phosphorylate a key threonine residue within the catalytic domain of the protein kinase C (PKC) superfamily that controls the stability and catalytic competence of these kinases.
Kelly, April P., Cantrell, Doreen A., Wood, C. David, Matthews, Sharon A.   +3 more
core   +1 more source

Involvement of different protein kinases and phospholipases A2 in phorbol ester (TPA)-induced arachidonic acid liberation in bovine platelets

Mediators of Inflammation, 2000
The effect of various phospholipase A2 and protein kinase inhibitors on the arachidonic acid liberation in bovine platelets induced by the protein kinase activator 12-O-tetradecanoylphorbol–13-acetate (TPA) was studied.
M. Lehr, K. Griessbach
doaj   +1 more source

DeepPurpose-based drug discovery in chondrosarcoma

Chinese Journal of Plastic and Reconstructive Surgery, 2022
Background: Chondrosarcoma (CS) is the second most common primary bone tumor, accounting for approximately 30% of all malignant bone tumors. Unfortunately, the efficacy of currently available drug therapies is limited.
Jianrui Li, Mingyue Shi, Zhiwei Chen, Yuyan Pan   +3 more
doaj   +1 more source

Trisubstituted pyrazolopyrimidines as novel angiogenesis inhibitors. [PDF]

, 2013
Current inhibitors of angiogenesis comprise either therapeutic antibodies (e.g. bevacicumab binding to VEGF-A) or small molecular inhibitors of receptor tyrosin kinases like e.g. sunitinib, which inhibits PDGFR and VEGFR.
Gucký, Tomáš, Stefan Zahler, Krystof, Vladimir, Strnad, Miroslav, Liebl, Johanna, Vollmar, Angelika M., Fürst, Robert, Vladimir Krystof, Robert Fürst, Sabine B Weitensteiner, Miroslav Strnad, Johanna Liebl, Havlíček, Libor, Tomáš Gucký, Weitensteiner, Sabine B., Zahler, Stefan, Libor Havlíček, Angelika M Vollmar   +17 more
core   +2 more sources

An Experimentally Validated Structure-Based Virtual Screening Approach to Identify Nucleotide-Binding Protein Inhibitors as a New Source of Kinase Inhibitors

Pharmaceuticals
Background/Objectives: Protein kinases represent major therapeutic targets because dysregulation of their phosphorylation activity is associated with several diseases, including cancer, diabetes, and inflammatory disorders.
Nicolas Bosc, Fabrice Carles, Jade Fogha, Blandine Baratte, Stéphane Bach, Samia Aci-Sèche, Stéphane Bourg, Sylvain Routier, Sandrine Ruchaud, Frédéric Buron, Pascal Bonnet   +10 more
doaj   +1 more source

Kinase-targeted cancer therapies: progress, challenges and future directions

Molecular Cancer, 2018
The human genome encodes 538 protein kinases that transfer a γ-phosphate group from ATP to serine, threonine, or tyrosine residues. Many of these kinases are associated with human cancer initiation and progression.
Khushwant S. Bhullar, Naiara Orrego Lagarón, Eileen M. McGowan, Indu Parmar, Amitabh Jha, Basil P. Hubbard, H. P. Vasantha Rupasinghe   +6 more
doaj   +1 more source