PKIDB: A Curated, Annotated and Updated Database of Protein Kinase Inhibitors in Clinical Trials
Molecules, 2018 The number of protein kinase inhibitors (PKIs) approved worldwide continues to grow steadily, with 39 drugs approved in the period between 2001 and January 2018.
Fabrice Carles +3 more
doaj +4 more sources
Marine-derived protein kinase inhibitors for neuroinflammatory diseases
BioMedical Engineering OnLine, 2018 Neuroinflammation is primarily characterized by overexpression of proinflammatory mediators produced by glial activation or immune cell infiltration. Several kinases have been shown to be critical mediators in neuroinflammation. One of the largest groups
Chong Ning +6 more
doaj +2 more sources
Protein kinase inhibitors for acute leukemia
Biomarker Research, 2018 Conventional treatments for acute leukemia include chemotherapy, radiation therapy, and intensive combined treatments (including bone marrow transplant or stem cell transplants). Novel treatment approaches are in active development.
Yuan Ling +3 more
doaj +2 more sources
Differentiating pulmonary hypertension associated with protein kinase inhibitors [PDF]
Pulmonary Circulation, 2022 Protein kinase inhibitors (PKIs) have been implicated in pulmonary vascular toxicities including risk factors for at least three of the five World Health Organization groups of pulmonary hypertension (PH).
Joshua A. Jacobs +2 more
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A comprehensive review of protein kinase inhibitors for cancer therapy
Expert Review of Anticancer Therapy, 2018 Introduction: Protein kinases are involved in various cellular functions. About 2% of the human genome encodes for protein kinases. Dysregulation of protein kinases is implicated in various processes of carcinogenesis.
Daruka Mahadevan
exaly +2 more sources
Protein Kinase Inhibitors and Oxidative Stress Modulate In Vivo Phosphorylation of Trypanosoma cruzi DNA Polymerase β [PDF]
PharmaceuticsBackground/Objectives: Protein kinases play crucial roles in signal transduction pathways that regulate growth and differentiation in Trypanosoma cruzi. These protein kinases are attractive targets to develop new drugs to treat Chagas disease.
Edio Maldonado +9 more
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Non-kinase targets of protein kinase inhibitors
Nature Reviews Drug Discovery, 2017 Lenka Munoz
exaly +2 more sources
Cardiotoxicity Induced by Protein Kinase Inhibitors in Patients with Cancer [PDF]
International Journal of Molecular Sciences, 2022 Agnieszka Adamczyk +2 more
exaly +2 more sources
Never Gonna Give You Up – Current Developments in Covalent Protein Kinase Inhibitors
CHIMIA, 2022 Covalent inhibitors have recently seen a revival in medicinal chemistry. Inhibitors addressing non-catalytic cysteine residues with weakly reactive electrophiles have been very successfully employed to target protein kinases, one of the major druggable ...
Laura Hillebrand, Matthias Gehringer
doaj +1 more source
Rule of five violations among the FDA-approved small molecule protein kinase inhibitors.
Pharmacological Research, 2023 Because genetic alterations including mutations, overexpression, translocations, and dysregulation of protein kinases are involved in the pathogenesis of many illnesses, this enzyme family is the target of many drug discovery programs in the ...
R. Roskoski
semanticscholar +1 more source