Results 11 to 20 of about 608,807 (260)
Protein kinase inhibitors for acute leukemia [PDF]
Biomarker Research, 2018 Conventional treatments for acute leukemia include chemotherapy, radiation therapy, and intensive combined treatments (including bone marrow transplant or stem cell transplants). Novel treatment approaches are in active development. Recently, protein kinase inhibitors are on clinical trials and offer hope as new drugs for acute leukemia treatment. This
Yuan Ling +3 more
openaire +4 more sources
The Kinase Specificity of Protein Kinase Inhibitor Peptide [PDF]
Frontiers in Pharmacology, 2021 G-protein-coupled-receptor (GPCR) signaling is exquisitely controlled to achieve spatial and temporal specificity. The endogenous protein kinase inhibitor peptide (PKI) confines the spatial and temporal spread of the activity of protein kinase A (PKA), which integrates inputs from three major types of GPCRs.
Yao Chen, Yao Chen, Bernardo L. Sabatini
openaire +4 more sources
Never Gonna Give You Up – Current Developments in Covalent Protein Kinase Inhibitors
CHIMIA, 2022 Covalent inhibitors have recently seen a revival in medicinal chemistry. Inhibitors addressing non-catalytic cysteine residues with weakly reactive electrophiles have been very successfully employed to target protein kinases, one of the major druggable ...
Laura Hillebrand, Matthias Gehringer
doaj +1 more source
Discovery of moiety preference by Shapley value in protein kinase family using random forest models
BMC Bioinformatics, 2022 Background Human protein kinases play important roles in cancers, are highly co-regulated by kinase families rather than a single kinase, and complementarily regulate signaling pathways.
Yu-Wei Huang +7 more
doaj +1 more source
Advances in RIPK1 kinase inhibitors
Frontiers in Pharmacology, 2022 Programmed necrosis is a new modulated cell death mode with necrotizing morphological characteristics. Receptor interacting protein 1 (RIPK1) is a critical mediator of the programmed necrosis pathway that is involved in stroke, myocardial infarction ...
Lu Chen +13 more
doaj +1 more source
Novel protein kinase signaling systems regulating lifespan identified by small molecule library screening using Drosophila. [PDF]
PLoS ONE, 2012 Protein kinase signaling cascades control most aspects of cellular function. The ATP binding domains of signaling protein kinases are the targets of most available inhibitors. These domains are highly conserved from mammals to flies.
Stephen R Spindler +4 more
doaj +1 more source
Biomolecules, 2022 Protein kinases are major drug targets. Most kinase inhibitors are directed against the adenosine triphosphate (ATP) cofactor binding site, which is largely conserved across the human kinome.
Christian Feldmann, Jürgen Bajorath
doaj +1 more source
Bivalent inhibitors of protein kinases [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2014 Protein kinases are key players in a large number of cellular signaling pathways. Dysregulated kinase activity has been implicated in a number of diseases, and members of this enzyme family are of therapeutic interest. However, due to the fact that most inhibitors interact with the highly conserved ATP-binding sites of kinases, it is a significant ...
Carrie M, Gower +2 more
openaire +2 more sources
Fast in-vitro screening of FLT3-ITD inhibitors using silkworm-baculovirus protein expression system.
PLoS ONE, 2022 We report expression and purification of a FLT3 protein with ITD mutation (FLT3-ITD) with a steady tyrosine kinase activity using a silkworm-baculovirus system, and its application as a fast screening system of tyrosine kinase inhibitors.
Naoki Yamamoto +3 more
doaj +1 more source
Frontiers in Chemistry, 2023 Receptor-Interacting serine/threonine-Protein Kinase 1 (RIPK1) emerged as an important driver of inflammation and, consequently, inflammatory pathologies.
Camilla Scarpellini +11 more
doaj +1 more source