Results 1 to 10 of about 1,152,447 (302)

Nanozymes as Enzyme Inhibitors

International Journal of Nanomedicine, 2021
Yaling Huang,1 Jian Jiang,1 Yanqiu Wang,1 Jie Chen,1 Juqun Xi1,2 1Institute of Translational Medicine, Department of Pharmacology, School of Medicine, Yangzhou University, Yangzhou, Jiangsu, 225001, People’s Republic of China; 2Jiangsu Key ...
Huang Y, Jiang J, Wang Y, Chen J, Xi J
doaj   +4 more sources

A Healthy and Ecologically Balanced Environment: An Argument for a Third Generation Right [PDF]

, 1993
Chymotrypsin-like serine proteases are found in high abundance in mast cell granules. By site-directed mutatgenesis, we have previously shown that basic amino acids in positions 143 and 192 (Arg and Lys respectively) of the human mast cell chymase are ...
Ahooghalandari, Parvin, Hanke, Nina, Hellman, Lars, Messinger, Josef, Thorpe, Michael, Witte, Andreas   +5 more
core   +20 more sources

Continuous enzyme activity assay for high-throughput classification of histone deacetylase 8 inhibitors

Exploration of Targeted Anti-tumor Therapy, 2023
Aim: Human histone deacetylase 8 (KDAC8) is a well-recognized pharmaceutical target in Cornelia de Lange syndrome and different types of cancer, particularly childhood neuroblastoma.
Markus Schweipert, Anuja Amurthavasan, Franz-Josef Meyer-Almes   +2 more
doaj   +1 more source

Harnessing the Bioactive Potential of Limonium spathulatum (Desf.) Kuntze: Insights into Enzyme Inhibition and Phytochemical Profile

Plants, 2023
This study assessed the halophyte species Limonium spathulatum (Desf.) as a possible source of natural ingredients with the capacity to inhibit enzymes related to relevant human health disorders and food browning.
Seria Youssef, Luisa Custódio, Maria João Rodrigues, Catarina G. Pereira, Ricardo C. Calhelha, József Jekő, Zoltán Cziáky, Karim Ben Hamed   +7 more
doaj   +1 more source

The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains

Antibiotics, 2023
Alginates play an important role in the resistance of mucoid strains of Pseudomonas aeruginosa to antibiotics, as well as their persistence by escaping the immune defense system.
Christian Hulen
doaj   +1 more source

A Review on Phyto-Therapeutic Approaches in Alzheimer’s Disease

Journal of Functional Biomaterials, 2023
Neurodegenerative diseases occur due to progressive and sometimes irreversible loss of function and death of nerve cells. A great deal of effort is being made to understand the pathogenesis of neurodegenerative diseases.
Mehtap Sahiner, Aynur Sanem Yilmaz, Buket Gungor, Nurettin Sahiner   +3 more
doaj   +1 more source

Eucalyptus grandis and Eucalyptus microcorys Essential Oils: in vitro Modulation of Hemostasis and Genotoxic Activity

Brazilian Archives of Biology and Technology, 2022
The genus Eucalyptus present high content of essential oil (EO). This study evaluated the pharmacological properties of Eucalyptus grandis (EG) and Eucalyptus microcorys (EM) EOs. The major component in both EOs was 1,8-Cineole.
Mariana Araújo Esposito, Pedro Henrique Souza Cesar, Rafaela Magalhães Brandão, Tatiane Silva de Abreu, Silvana Marcussi   +4 more
doaj   +1 more source

Comprehensive Biological and Chemical Evaluation of Two Seseli Species (S. gummiferum and S. transcaucasicum)

Antioxidants, 2021
Seseli L. is one of the largest genera of the Apiaceae family widely known for their traditional uses as herbal remedies. In the present study, the methanolic and water extracts of two Seseli species, S. gummiferum and S.
Gokhan Zengin, Dejan Stojković, Mohamad Fawzi Mahomoodally, Bibi Sharmeen Jugreet, Mehmet Yavuz Paksoy, Marija Ivanov, Uroš Gašić, Monica Gallo, Domenico Montesano   +8 more
doaj   +1 more source

Preparation of Alcohol Dehydrogenase–Zinc Phosphate Hybrid Nanoflowers through Biomimetic Mineralization and Its Application in the Inhibitor Screening

Molecules, 2023
A biomimetic mineralization method was used in the facile and rapid preparation of nanoflowers for immobilizing alcohol dehydrogenase (ADH). The method mainly uses ADH as an organic component and zinc phosphate as an inorganic component to prepare flower-
Mao-Ling Luo, Hua Chen, Guo-Ying Chen, Shengpeng Wang, Yitao Wang, Feng-Qing Yang   +5 more
doaj   +1 more source

Vanillin enones as selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII. The out of the active site pocket for the design of selective inhibitors?

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
New C-glycosides and α,β-unsaturated ketones incorporating the 4-hydroxy-3-methoxyphenyl (vanillin) moiety as inhibitors of carbonic anhydrase (CA, EC 4.2.1.1) isoforms have been investigated.
Leonardo E. Riafrecha, Macarena S. Le Pors, Martín J. Lavecchia, Silvia Bua, Claudiu T. Supuran, Pedro A. Colinas   +5 more
doaj   +1 more source