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Inhibitors of glyoxalase enzymes
Biochemical and Biophysical Research Communications, 1980Abstract Both glyoxalase enzymes from various sources are inhibited by nucleotides, nucleosides and a series of structurally related compounds in an apparently cooperative manner. In general, aromatic compounds, which contain heterocyclic nitrogen and/or have amino groups on the aromatic ring, are effective inhibitors of these enzymes.
B, Oray, S J, Norton
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Enzyme Inhibitors in the Treatment of Hypertension.
Annals of Internal Medicine, 1961Excerpt The use of enzyme inhibitors in the treatment of hypertension is currently being investigated.
A N, BREST, J H, MOYER
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Enzyme kinetics in relation to enzyme inhibitors
Biochemical Pharmacology, 1973Abstract A Large number of pharmacologically important compounds have been found to act as enzyme inhibitors and a kinetic study of the inhibitory process can provide important information on the potency of the compound and on its mode of interaction with the enzyme.
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Inhibitors of Kinin-Forming Enzymes
Agents and Actions, 1976The typical trypsin-like protease in animals were plasmin, kallikrein, thrombin, factor X, XI, XII, cathepsin B, plasminogen tissue activator and urokinase, and so on. Among them plasmin and kallikrein have kinin-forming activity. A synthetic reversible inhibitor of plasmin, and anticoagulant factor of blood, has been extensively studied.
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Angiotensin-Converting Enzyme Inhibitors
Journal of Hypertension, 1991The introduction of angiotensin-converting enzyme (ACE) inhibitors for the treatment of hypertension and heart failure is probably the most important advance in cardiovascular pharmacotherapy in the last few decades. Although the role of the renin-angiotensin system (RAS) in cardiovascular diseases had been investigated extensively for more than 70 yr,
Irene Gavras, Haralambos Gavras
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2004
Focusing on the development of enzyme inhibitors as therapeutic drugs, Enzymes and Their Inhibitors: Drug Development provides a concise overview of the chemistry of major types of enzymes and their inhibitors. The opening chapters introduce readers to the structure, functions, mechanisms, and kinetics of enzymes, including their use as disease ...
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Focusing on the development of enzyme inhibitors as therapeutic drugs, Enzymes and Their Inhibitors: Drug Development provides a concise overview of the chemistry of major types of enzymes and their inhibitors. The opening chapters introduce readers to the structure, functions, mechanisms, and kinetics of enzymes, including their use as disease ...
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Inhibitors of mitochondrial enzymes
Pharmacology & Therapeutics, 1979J B, Clark, J M, Land
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The Use of Enzyme Inhibitors in Drug Discovery: Current Strategies and Future Prospects
Current Enzyme Inhibition, 2023Kuldeep Singh +2 more
exaly