Results 21 to 30 of about 2,177,587 (253)
Zanco Journal of Medical Sciences, 2020 Genetic variations between individuals usually leads to differences in the drug response as it could affect both pharmacokinetic and pharmacodynamic processes. An example of mutation of genes that affect drug targets (pharmacodynamic) is VKORC1 gene that
Rojgar Hamed Ali
doaj +1 more source
A Review on Phyto-Therapeutic Approaches in Alzheimer’s Disease
Journal of Functional Biomaterials, 2023 Neurodegenerative diseases occur due to progressive and sometimes irreversible loss of function and death of nerve cells. A great deal of effort is being made to understand the pathogenesis of neurodegenerative diseases.
Mehtap Sahiner +3 more
doaj +1 more source
Evaluation Of Clinically Important Drug Interactions Involving Angiotensin-Converting Enzyme Inhibitors Among Cardiac Patients [QP609.A53 F219 2008 f rb]. [PDF]
, 2008 Perencat penukar enzim angiotensin (ACEIs) telah digunakan secara meluas untuk merawat hipertensi dan penyakit kardiovaskular yang lain. Interaksi ubat-ACEI adalah merupakan masalah kesihatan yang signifikan dan perlu penyelidikan lanjut.
Amir Abdelkarim Farag, Omalhassan
core +1 more source
Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages [PDF]
, 2012 Latent M. tuberculosis infection presents one of the major obstacles in the global eradication of tuberculosis (TB). Cholesterol plays a critical role in the persistence of M. tuberculosis within the macrophage during latent infection.
Russell, AJ +76 more
core +2 more sources
From sequence to enzyme mechanism using multi-label machine learning [PDF]
, 2014 Background: In this work we predict enzyme function at the level of chemical mechanism, providing a finer granularity of annotation than traditional Enzyme Commission (EC) classes.
De Ferrari, Luna; id_orcid +6 more
core +1 more source
Molecular Logic as a Means to Assess Therapeutic Antidotes
Frontiers in Chemistry, 2019 An emerging direction in the area of molecular logic and computation is developing molecular-scale devices that can operate in complex biological environments, such as within living cells, which are beyond the reach of conventional electronic devices ...
Linor Unger-Angel +2 more
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Human carbonic anhydrase IX (CA IX), a protein specifically expressed on the surface of solid tumour cells, represents a validated target both for anticancer therapy and diagnostics.
Michael Kugler +10 more
doaj +1 more source
Brazilian Archives of Biology and Technology, 2022 The genus Eucalyptus present high content of essential oil (EO). This study evaluated the pharmacological properties of Eucalyptus grandis (EG) and Eucalyptus microcorys (EM) EOs. The major component in both EOs was 1,8-Cineole.
Mariana Araújo Esposito +4 more
doaj +1 more source
Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF [PDF]
, 2008 Background To develop antibacterial agents having novel modes of action against bacterial cell wall biosynthesis, we targeted the essential MurF enzyme of the antibiotic resistant pathogen Pseudomonas aeruginosa.
Sanschagrin, François +13 more
core +1 more source
Carbazole scaffolds in cancer therapy: a review from 2012 to 2018
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 For over half a century, the carbazole skeleton has been the key structural motif of many biologically active compounds including natural and synthetic products.
Samar Issa +6 more
doaj +1 more source