NMR analysis of the dynamic exchange of the NS2B cofactor between open and closed conformations of the West Nile virus NS2B-NS3 protease. [PDF]
PLoS Neglected Tropical Diseases, 2009 BACKGROUND: The two-component NS2B-NS3 proteases of West Nile and dengue viruses are essential for viral replication and established targets for drug development.
Xun-Cheng Su +5 more
doaj +4 more sources
Small Molecule Protease Inhibitors as Model Peptidomimetics [PDF]
PharmaceuticalsProteases constitute one of the largest sub-classes of enzymes, accounting for ca. 2% of the proteins encoded in the human genome. They play a key role in protein degradation and signaling, regulating a variety of physiological processes.
Patricia Gomez-Gutierrez, Juan J. Perez
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Protease inhibitors targeting coronavirus and filovirus entry [PDF]
Antiviral Research, 2015 Highlights • We identify vinylsulfones as lead candidate inhibitors of Ebola virus and SARS-CoV.• K11777 inhibited Ebola virus and SARS-CoV entry in the sub-nanomolar range.• Potent inhibition correlated with the presence of a basic piperazine ring at P3.
Yanchen Zhou +10 more
semanticscholar +3 more sources
Frontiers in Cellular and Infection Microbiology, 2017 The publication of the first tick sialome (salivary gland transcriptome) heralded a new era of research of tick protease inhibitors, which represent important constituents of the proteins secreted via tick saliva into the host.
Jindřich Chmelař +5 more
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Role of Protease-Inhibitors in Ocular Diseases
Molecules, 2014 It has been demonstrated that the balance between proteases and protease-inhibitors system plays a key role in maintaining cellular and tissue homeostasis. Indeed, its alteration has been involved in many ocular and systemic diseases.
Nicola Pescosolido +5 more
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HIV protease inhibitors: a review of molecular selectivity and toxicity
HIV/AIDS: Research and Palliative Care, 2015 Zhengtong Lv,* Yuan Chu,* Yong Wang Department of Immunology, School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic of China *Both authors contributed equally to this work ...
Lv Z, Chu Y, Wang Y
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Marine Drugs, 2013 The Kunitz-type protease inhibitors are the best-characterized family of serine protease inhibitors, probably due to their abundance in several organisms.
Caroline B. F. Mourão +1 more
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Optimized pipeline and designer cells for synthetic-biology-based high-throughput screening of viral protease inhibitors [PDF]
Cell Reports: MethodsSummary: A reliable, efficient, high-throughput pipeline to evaluate viral protease inhibitors would enhance antiviral drug discovery. Methods such as crystallography and phenotypic screening are often constrained by complex assay conditions, limited ...
Shlomi Edri +10 more
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Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors
bioRxiv, 2022 Vaccines and drugs have helped reduce disease severity and blunt the spread of SARS-CoV-2. However, ongoing virus transmission, continuous evolution, and increasing selective pressures have the potential to yield viral variants capable of resisting these
S. Moghadasi +14 more
semanticscholar +1 more source
Efficacy and safety of 3CL protease inhibitors in patients with mild or moderate COVID-19: a systematic review and meta-analysis of randomized controlled trials [PDF]
Virology JournalBackground Remdesivir has been established as a safe treatment for patients with COVID-19. However, given the SARS-CoV-2 random mutations, 3CL protease inhibitors have been studied in recent randomized controlled trials.
Nicole Jean Lee +6 more
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