Results 1 to 10 of about 1,407,327 (308)

Spatial mapping of SARS-CoV-2 and H1N1 lung injury identifies differential transcriptional signatures

Cell Reports Medicine, 2021
Summary: Severe SARS-CoV-2 infection often leads to the development of acute respiratory distress syndrome (ARDS), with profound pulmonary patho-histological changes post-mortem. It is not clear whether ARDS from SARS-CoV-2 is similar to that observed in
Camilla Margaroli, Paul Benson, Nirmal S. Sharma, Matthew C. Madison, Sarah W. Robison, Nitin Arora, Kathy Ton, Yan Liang, Liang Zhang, Rakesh P. Patel, Amit Gaggar   +10 more
doaj   +1 more source

The endothelial glycocalyx in critical illness: A pediatric perspective

Matrix Biology Plus, 2022
The vascular endothelium is the interface between circulating blood and end organs and thus has a critical role in preserving organ function. The endothelium is lined by a glycan-rich glycocalyx that uniquely contributes to endothelial function through ...
Robert P. Richter, Gregory A. Payne, Namasivayam Ambalavanan, Amit Gaggar, Jillian R. Richter   +4 more
doaj   +1 more source

Spatial transcriptomic profiling of coronary endothelial cells in SARS-CoV-2 myocarditis

Frontiers in Medicine, 2023
ObjectivesOur objective was to examine coronary endothelial and myocardial programming in patients with severe COVID-19 utilizing digital spatial transcriptomics.BackgroundSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has well-established ...
Camilla Margaroli, Camilla Margaroli, Paul Benson, Maria G. Gastanadui, Maria G. Gastanadui, Chunyan Song, Chunyan Song, Chunyan Song, Liliana Viera, Liliana Viera, Liliana Viera, Dongqi Xing, Dongqi Xing, Dongqi Xing, Dongqi Xing, Dongqi Xing, J. Michael Wells, J. Michael Wells, J. Michael Wells, J. Michael Wells, J. Michael Wells, J. Michael Wells, Rakesh Patel, Rakesh Patel, Rakesh Patel, Amit Gaggar, Amit Gaggar, Amit Gaggar, Amit Gaggar, Amit Gaggar, Amit Gaggar, Amit Gaggar, Gregory A. Payne, Gregory A. Payne, Gregory A. Payne, Gregory A. Payne, Gregory A. Payne, Gregory A. Payne   +37 more
doaj   +1 more source

Diet, microbiota, and the mucus layer: The guardians of our health

Frontiers in Immunology, 2022
The intestinal tract is an ecosystem in which the resident microbiota lives in symbiosis with its host. This symbiotic relationship is key to maintaining overall health, with dietary habits of the host representing one of the main external factors ...
Francesco Suriano, Elisabeth E. L. Nyström, Domenico Sergi, Jenny K. Gustafsson   +3 more
doaj   +1 more source

Individual or combinational use of phytase, protease, and xylanase for the impacts on total tract digestibility of corn, soybean meal, and distillers dried grains with soluble fed to pigs [PDF]

Animal Bioscience, 2023
Objective This study was to evaluate the effects of individual or combinational use of phytase, protease, and xylanase on total tract digestibility of corn, soybean meal, and distillers dried grains with soluble (DDGS) fed to pigs.
Adsos Adami Passos, Vitor Hugo Cardoso Moita, Sung Woo Kim   +2 more
doaj   +1 more source

Zika virus cleaves GSDMD to disseminate prognosticable and controllable oncolysis in a human glioblastoma cell model

Molecular Therapy: Oncolytics, 2023
Glioblastoma (GBM) is the most common aggressive malignant brain cancer and is chemo- and radioresistant, with poor therapeutic outcomes. The “double-edged sword” of virus-induced cell death could be a potential solution if the oncolytic virus ...
Yu-Ting Kao, Hsin-I Wang, Chi-Ting Shie, Chiou-Feng Lin, Michael M.C. Lai, Chia-Yi Yu   +5 more
doaj   +1 more source

Peroxisomal Proteostasis Involves a Lon Family Protein That Functions as Protease and Chaperone [PDF]

, 2012
Proteins are subject to continuous quality control for optimal proteostasis. The knowledge of peroxisome quality control systems is still in its infancy. Here we show that peroxisomes contain a member of the Lon family of proteases (Pln).
Aksam, Antonenkov, Arnold, Bartoszewska, Bender, Bota, Buchner, Dobson, Ellis, Fraaije, Franke, Goldberg, Guinier, Hanson, Hartl, Hillenga, Islinger, Iyer, Jaenicke, Jahn, Kiel, Kiel, Kikuchi, Kozin, Lee, Lingard, Liu, Meijer, Nettleship, Nijland, Okumoto, Omi, Opaliński, Paraszkiewicz, Petoukhov, Petoukhov, Petoukhov, Powers, Quiocho, Reeder, Rep, Roessle, Roudiak, Sambrook, Sauer, Stahlberg, Steinberg, Svergun, Tyedmers, van Dijken, van Roermund, Venkatesh, Volkov, von Janowsky, Wagner, Walton, Wanders, Waterham, West   +58 more
core   +7 more sources

Rapid enzymatic test for phenotypic HIV protease drug resistance [PDF]

, 2003
A phenotypic resistance test based on recombinant expression of the active HIV protease in E. coli from patient blood samples was developed. The protease is purified in a rapid onestep procedure as active enzyme and tested for inhibition by five selected
Assfalg-Machleidt, Irmgard, Helm, K. von der, Hoffmann, D., Koszinowski, U., Machleidt, Werner, Nitschko, H.   +5 more
core   +1 more source

The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes. [PDF]

, 2018
Activation of the inflammasome pathway is crucial for effective intracellular host defense. The mitochondrial network plays an important role in inflammasome regulation but the mechanisms linking mitochondrial homeostasis to attenuation of inflammasome ...
Alnemri, Emad S., Champagne, Claudia, Doiron, Karine, Douglas, Todd, Leiva-Torres, Gabriel André, Mayes, Lindsey, Rodrigue-Gervais, Ian Gaël, Saleh, Maya, Vanié, Paulin, Vidal, Silvia M.   +9 more
core   +4 more sources

Reprogramming of the Caseinolytic Protease by ADEP Antibiotics: Molecular Mechanism, Cellular Consequences, Therapeutic Potential

Frontiers in Molecular Biosciences, 2021
Rising antibiotic resistance urgently calls for the discovery and evaluation of novel antibiotic classes and unique antibiotic targets. The caseinolytic protease Clp emerged as an unprecedented target for antibiotic therapy 15 years ago when it was ...
Heike Brötz-Oesterhelt, Heike Brötz-Oesterhelt, Andreas Vorbach   +2 more
doaj   +1 more source