Results 11 to 20 of about 1,002,899 (266)

Protease inhibitors targeting the main protease and papain-like protease of coronaviruses [PDF]

Expert Opinion on Therapeutic Patents, 2020
The two cysteine proteases from the coronaviruses, which produced deadly outbreaks in the last two decades, SARS CoV-1/2, and MERS, the main protease (Mpro) and the papain-like protease (PLP) are conserved among the three pathogens and started to be considered as exciting drug targets for developing antivirals.We review the drug design landscape in the
Capasso, Clemente, Nocentini, Alessio, Supuran, Claudiu T   +2 more
openaire   +3 more sources

Protease-anti-protease compartmentalization in SARSCoV-2 ARDS: therapeutic implications

, 2022
Background: Interleukin-6 (IL-6) is elevated in SARS-CoV-2 infection. IL-6 regulates acute-phase proteins, such as alpha-1 antitrypsin (AAT), a key lung anti-protease.
Noel G McElvaney (7895978), Ross E Zumwalt (12189020), Cormac McCarthy (1849417), Jennifer Clarke (7899281), Emer Reeves (7895438), Patrick W. Mallon (6269702), Robert S Hagan (12189005), Oisin Mcelvaney (7898561), Jose L Torres-Castillo (12189004), Suzanne L Meinig (12189002), Natalie McEvoy (7899251), Gerard Curley (7897901), Leigh B Thorne (12189014), Oliver McElvaney (7898186), Takanori Asakura (3551786), Richard C Boucher (12189023), Tomas Carroll (7896269), Kenichi Okuda (12189021), Mark Murphy (7895882), Grace Hogan (7895543), Alain Borczuk (451970), Matthew C Wolfgang (12189022), Yu Mikami (673193), Claudie Gabillard (7899800)   +23 more
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Rapid enzymatic test for phenotypic HIV protease drug resistance [PDF]

, 2003
A phenotypic resistance test based on recombinant expression of the active HIV protease in E. coli from patient blood samples was developed. The protease is purified in a rapid onestep procedure as active enzyme and tested for inhibition by five selected
Machleidt, Werner, Hoffmann, D., Assfalg-Machleidt, Irmgard, Helm, K. von der, Nitschko, H., Koszinowski, U.   +5 more
core   +1 more source

Lipopeptides as dimerization inhibitors of HIV-1 protease [PDF]

, 1999
In AIDS therapy, attempts have been made to inhibit the virus-encoded enzymes, e.g, HIV-1 protease, using active site-directed inhibitors. This approach is questionable, however, due to virus mutations and the high toxicity of the drugs, An alternative ...
Schramm, W., Schramm, H. J., Büttner, J., de Rosny, E., Dick, A., Reboud-Ravaux, M.   +5 more
core   +1 more source

Protease mediated maturation of HIV: Inhibitors of protease and the maturation process [PDF]

, 2012
Protease-mediated maturation of HIV-1 virus particles is essential for virus infectivity. Maturation occurs concomitant with immature virus particle release and is mediated by the viral protease (PR), which sequentially cleaves the Gag and Gag-Pol ...
Catherine S. Adamson, Adamson, Catherine S   +1 more
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Protease-inhibitor interaction sites nomenclature

, 2023
Protease specificity pockets interacting with corresponding inhibitor binding ...
Annika W. Nonboe (15422756)
core   +1 more source

Peroxisomal Proteostasis Involves a Lon Family Protein That Functions as Protease and Chaperone [PDF]

, 2012
Proteins are subject to continuous quality control for optimal proteostasis. The knowledge of peroxisome quality control systems is still in its infancy. Here we show that peroxisomes contain a member of the Lon family of proteases (Pln).
Kikhney, Alexey, Roermund, Carlo W.T. van,, van Roermund, C. W. T., Opalinski, L., Kikhney, A., Williams, Chris,, de Boer, R., Veenhuis, Marten, Kikhney, Alexey,, de Boer, Rinse, Williams, C., Williams, Chris, Opalinski, Lukasz, Bartoszewska, M., Klei, Ida J. van der,, van der Klei, Ida J., Boer, Rinse de,, Opaliński, Łukasz,, van der Klei, I. J., van Roermund, Carlo W. T., Veenhuis, Marten,, Veenhuis, M., van der Klei, Ida J.; id_orcid, Bartoszewska, Magdalena, Bartoszewska, Magdalena,   +24 more
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The role of the HIV-1 protease substrate in therapy resistance [PDF]

, 2015
In Switzerland and Germany up to a half of the first-line regimens include protease inhibitors (PIs) [1, 2]. Although in the Swiss HIV Cohort Study (SHCS) most patients under antiretroviral therapy (ART) have suppressed viral loads [3], every third ...
Kletenkov, Konstantin
core   +1 more source

The Proteases of Plants (IV) [PDF]

Annals of Botany, 1905
(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
openaire   +11 more sources

Proteases, Protease-Activated Receptors, and Atherosclerosis [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2018
Coagulation activation by the TF (tissue factor) pathway plays pivotal roles in triggering platelets and precipitating acute coronary syndromes. Although dual antiplatelet therapy is effective in secondary cardiovascular prevention, combining platelet antagonism with low-dose aspirin and the oral coagulation FXa antagonist rivaroxaban has a synergistic
openaire   +2 more sources