Results 11 to 20 of about 1,086,799 (301)

Protease-anti-protease compartmentalization in SARSCoV-2 ARDS: therapeutic implications [PDF]

, 2022
Background: Interleukin-6 (IL-6) is elevated in SARS-CoV-2 infection. IL-6 regulates acute-phase proteins, such as alpha-1 antitrypsin (AAT), a key lung anti-protease.
Noel G McElvaney (7895978), Ross E Zumwalt (12189020), Cormac McCarthy (1849417), Jennifer Clarke (7899281), Emer Reeves (7895438), Patrick W. Mallon (6269702), Robert S Hagan (12189005), Oisin Mcelvaney (7898561), Jose L Torres-Castillo (12189004), Suzanne L Meinig (12189002), Natalie McEvoy (7899251), Gerard Curley (7897901), Leigh B Thorne (12189014), Oliver McElvaney (7898186), Takanori Asakura (3551786), Richard C Boucher (12189023), Tomas Carroll (7896269), Kenichi Okuda (12189021), Mark Murphy (7895882), Grace Hogan (7895543), Alain Borczuk (451970), Matthew C Wolfgang (12189022), Yu Mikami (673193), Claudie Gabillard (7899800)   +23 more
core   +4 more sources

Heparin modulates the endopeptidase activity of Leishmania mexicana cysteine protease cathepsin L-Like rCPB2.8 [PDF]

, 2013
Cysteine protease B is considered crucial for the survival and infectivity of the Leishmania in its human host. Several microorganism pathogens bind to the heparin-like glycosaminoglycans chains of proteoglycans at host-cell surface to promote their ...
Gesteira, Tarsis F., Juliano, Luiz, Tersariol, Ivarne L.S., Westrop, Gareth, Almeida, Paulo C, Souza, Gerson A., Judice, W.A.S., Sansevero, Thiago M., Sanderson, Sanya J, Coombs, Graham, Manfredi, Marcella A, Shida, Claudio S.   +11 more
core   +4 more sources

Rapid enzymatic test for phenotypic HIV protease drug resistance [PDF]

, 2003
A phenotypic resistance test based on recombinant expression of the active HIV protease in E. coli from patient blood samples was developed. The protease is purified in a rapid onestep procedure as active enzyme and tested for inhibition by five selected
Machleidt, Werner, Hoffmann, D., Assfalg-Machleidt, Irmgard, Helm, K. von der, Nitschko, H., Koszinowski, U.   +5 more
core   +1 more source

Protease mediated maturation of HIV: Inhibitors of protease and the maturation process [PDF]

, 2012
Protease-mediated maturation of HIV-1 virus particles is essential for virus infectivity. Maturation occurs concomitant with immature virus particle release and is mediated by the viral protease (PR), which sequentially cleaves the Gag and Gag-Pol ...
Catherine S. Adamson, Adamson, Catherine S   +1 more
core   +1 more source

Lipopeptides as dimerization inhibitors of HIV-1 protease [PDF]

, 1999
In AIDS therapy, attempts have been made to inhibit the virus-encoded enzymes, e.g, HIV-1 protease, using active site-directed inhibitors. This approach is questionable, however, due to virus mutations and the high toxicity of the drugs, An alternative ...
Schramm, W., Schramm, H. J., Büttner, J., de Rosny, E., Dick, A., Reboud-Ravaux, M.   +5 more
core   +1 more source

Cryptococcal Protease(s) and the Activation of SARS-CoV-2 Spike (S) Protein

Cells, 2022
In this contribution, we report on the possibility that cryptococcal protease(s) could activate the SARS-CoV-2 spike (S) protein. The S protein is documented to have a unique four-amino-acid sequence (underlined, SPRRAR↓S) at the interface between the S1
Nozethu Mjokane, Maphori Maliehe, Olufemi S. Folorunso, Adepemi O. Ogundeji, Onele M. N. Gcilitshana, Jacobus Albertyn, Carolina H. Pohl, Olihile M. Sebolai   +7 more
doaj   +1 more source

Shotgun Proteomics Revealed Preferential Degradation of Misfolded In Vivo Obligate GroE Substrates by Lon Protease in Escherichia coli

Molecules, 2022
The Escherichia coli chaperonin GroEL/ES (GroE) is one of the most extensively studied molecular chaperones. So far, ~80 proteins in E. coli are identified as GroE substrates that obligately require GroE for folding in vivo. In GroE-depleted cells, these
Tatsuya Niwa, Yuhei Chadani, Hideki Taguchi   +2 more
doaj   +1 more source

Identification of semicarbazones, thiosemicarbazones and triazine nitriles as inhibitors of Leishmania mexicana cysteine protease CPB [PDF]

, 2013
Cysteine proteases of the papain superfamily are present in nearly all eukaryotes. They play pivotal roles in the biology of parasites and inhibition of cysteine proteases is emerging as an important strategy to combat parasitic diseases such as sleeping
Mottram, Jeremy C, Coombs, Graham H, Schröder, Jörg, Marhöfer, Richard J, Noack, Sandra, Selzer, Paul M   +5 more
core   +4 more sources

Statistical Optimization of the Production of NaCl-Tolerant Proteases by a Moderate Halophile, Virgibacillus sp. SK37

Food Technology and Biotechnology, 2015
The objectives of this study are to optimize the conditions for providing high yield of NaCl-tolerant extracellular protease from Virgibacillus sp. SK37 based on a fi sh-based medium and to investigate the eff ects of the key factors (mass per volume ...
Sornchai Sinsuwan, Anuvat Jangchud, Sureelak Rodtong, Sittirak Roytrakul, Jirawat Yongsawatdigul   +4 more
doaj   +1 more source

Inibidor de protease

, 2013
Os inibidores de protease evitam a maturação das proteínas virais dentro das partículas de HIVEducação Superior::Ciências da Saúde ...
Howard Hughes Medical Institute (HHMI)
core   +3 more sources