Results 11 to 20 of about 930,417 (268)

Protease inhibitors targeting the main protease and papain-like protease of coronaviruses [PDF]

Expert Opinion on Therapeutic Patents, 2020
The two cysteine proteases from the coronaviruses, which produced deadly outbreaks in the last two decades, SARS CoV-1/2, and MERS, the main protease (Mpro) and the papain-like protease (PLP) are conserved among the three pathogens and started to be considered as exciting drug targets for developing antivirals.We review the drug design landscape in the
Capasso, Clemente, Nocentini, Alessio, Supuran, Claudiu T   +2 more
openaire   +3 more sources

Shotgun Proteomics Revealed Preferential Degradation of Misfolded In Vivo Obligate GroE Substrates by Lon Protease in Escherichia coli

Molecules, 2022
The Escherichia coli chaperonin GroEL/ES (GroE) is one of the most extensively studied molecular chaperones. So far, ~80 proteins in E. coli are identified as GroE substrates that obligately require GroE for folding in vivo. In GroE-depleted cells, these
Tatsuya Niwa, Yuhei Chadani, Hideki Taguchi   +2 more
doaj   +1 more source

Statistical Optimization of the Production of NaCl-Tolerant Proteases by a Moderate Halophile, Virgibacillus sp. SK37

Food Technology and Biotechnology, 2015
The objectives of this study are to optimize the conditions for providing high yield of NaCl-tolerant extracellular protease from Virgibacillus sp. SK37 based on a fi sh-based medium and to investigate the eff ects of the key factors (mass per volume ...
Sornchai Sinsuwan, Anuvat Jangchud, Sureelak Rodtong, Sittirak Roytrakul, Jirawat Yongsawatdigul   +4 more
doaj   +1 more source

A rise in the frequency of lasR mutant Pseudomonas aeruginosa among keratitis isolates between 1993 and 2021

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionPseudomonas aeruginosa causes vision threatening keratitis. The LasR transcription factor regulates virulence factors in response to the quorum sensing molecule N-3-oxo-dodecanoyl-L-homoserine lactone. P.
Robert M. Q. Shanks, Sarah Atta, Nicholas A. Stella, Chollapadi V. Sundar-Raj, John E. Romanowski, Arman S. Grewal, Hazel Q. Shanks, Sonya M. Mumper, Deepinder K. Dhaliwal, Alex Mammen, Jake D. Callaghan, Rachel C. Calvario, Eric G. Romanowski, Regis P. Kowalski, Michael E. Zegans, Michael E. Zegans, Vishal Jhanji   +16 more
doaj   +1 more source

LIMITED PROTEOLYSIS OF FIBRINOGEN BY PROTEASE OF Gloydius halys halys SNAKE VENOM [PDF]

Biotechnologia Acta, 2021
Aim. One of the approaches for studying structure and functions of proteins is their limited proteolysis. Proteolytic fragments of macromolecules can preserve the biological activity and can be used for the study of their structural and functional ...
Ye. M. Stohnii , A. V. Rebriev , O. V. Hornytska, O. Yu. Slominskiy , O. P. Kostiuchenko, K. P. Klymenko , V. O. Chernyshenko   +6 more
doaj   +1 more source

EFFECT OF DIFFERENT LEVELS AGROECOLOGICAL LOADS ON BIOCHEMICAL CHARACTERISTICS OF SOIL

Юг России: экология, развитие, 2017
Aim. To study the effect of different levels of agri-environmental loads on the enzymatic activity of the soil.Methods. Isolation of soil fauna was conducted by thermogradient.
A. V. Shchur, D. V. Vinogradov, V. P. Valckho   +2 more
doaj   +1 more source

Cis-Allosteric Regulation of HIV-1 Reverse Transcriptase by Integrase

Viruses, 2022
Reverse transcriptase (RT) and integrase (IN) are encoded tandemly in the pol genes of retroviruses. We reported recently that HIV-1 RT and IN need to be supplied as the pol precursor intermediates, in which RT and IN are in fusion form (RTIN) to exert ...
Takao Masuda, Osamu Kotani, Masaru Yokoyama, Yuya Abe, Gota Kawai, Hironori Sato   +5 more
doaj   +1 more source

Endocan in Acute Leukemia: Current Knowledge and Future Perspectives

Biomolecules, 2022
Endocan is a soluble dermatan sulfate proteoglycan expressed by endothelial cells and detected in serum/plasma. Its expression is increased in tumors/tumor vessels in several human malignancies, and high expression (high serum/plasma levels or tumor ...
Håkon Reikvam, Kimberley Joanne Hatfield, Øystein Wendelbo, Roald Lindås, Philippe Lassalle, Øystein Bruserud   +5 more
doaj   +1 more source

Cases inefficient antiretroviral therapy for HIV-1 in children

Журнал инфектологии, 2017
Aim. Study cases virologic failure ART HIV-1 in children.Materials and methods. The blood plasma samples of 6 patients with HIV infection were used, identified under 1 year of life, from the North-West Federal District of the Russian Federation, received
Yu. V. Ostankova, A. V. Semenov, M. A. Churina, A. A. Totolian   +3 more
doaj   +1 more source

Dermatophyte infection: from fungal pathogenicity to host immune responses

Frontiers in Immunology, 2023
Dermatophytosis is a common superficial infection caused by dermatophytes, a group of pathogenic keratinophilic fungi. Apart from invasion against skin barrier, host immune responses to dermatophytes could also lead to pathologic inflammation and tissue ...
Ruixin Deng, Ruixin Deng, Ruixin Deng, Ruixin Deng, Xiaowen Wang, Xiaowen Wang, Xiaowen Wang, Xiaowen Wang, Ruoyu Li, Ruoyu Li, Ruoyu Li, Ruoyu Li   +11 more
doaj   +1 more source