Results 31 to 40 of about 1,086,799 (301)

A new method for the Characterization of Strain-Specific Conformational Stability of Protease-Sensitive and Protease Resistant PrPSc [PDF]

, 2010
Although proteinacious in nature, prions exist as strains with specific self-perpetuating biological properties. Prion strains are thought to be associated with different conformers of PrPSc, a disease-associated isoform of the host-encoded cellular ...
Gabriele Vaccari, Laura Pirisinu, Marcon Stefano, Fazzi, P., Pirisinu Laura, Michele Di Bari, Nonno Romolo, Bari, M., Di, Marcon, S., Langeveld Jan, Paola Fazzi, Cardone, F., Vaccari Gabriele, Vaccari, G., Langeveld, J.P.M., Galeno Roberta, Roberta Galeno, Pirisinu, L., Esposito Elena, Fazzi Paola, Jan Langeveld, Nonno, R., Umberto Agrimi, D'Agostino, C., Elena Esposito, Stefano Marcon, Esposito, E., Claudia D'Agostino, Agrimi Umberto, Agrimi, U., Agostino, C., D', Di Bari, M., D'Agostino Claudia, Romolo Nonno, Di Bari Michele   +34 more
core   +2 more sources

Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease

eLife, 2019
The secretion of peptides and proteins is essential for survival and ecological adaptation of bacteria. Dual-functional ATP-binding cassette transporters export antimicrobial or quorum signaling peptides in Gram-positive bacteria.
Silvia C Bobeica, Shi-Hui Dong, Liujie Huo, Nuria Mazo, Martin I McLaughlin, Gonzalo Jiménez-Osés, Satish K Nair, Wilfred A van der Donk   +7 more
doaj   +1 more source

Identification of a Novel Thermostable Alkaline Protease from Bacillus megaterium-TK1 for the Detergent and Leather Industry

Biology, 2020
An increased need by the green industry for enzymes that can be exploited for eco-friendly industrial applications led us to isolate and identify a unique protease obtained from a proteolytic Bacillus megaterium-TK1 strain from a seawater source.
Tamilvendan Manavalan, Arulmani Manavalan, Shiyamsundar Ramachandran, Klaus Heese   +3 more
doaj   +1 more source

Thimet Oligopeptidase Biochemical and Biological Significances: Past, Present, and Future Directions

Biomolecules, 2020
Thimet oligopeptidase (EC 3.4.24.15; EP24.15, THOP1) is a metallopeptidase ubiquitously distributed in mammalian tissues. Beyond its previously well characterized role in major histocompatibility class I (MHC-I) antigen presentation, the recent ...
Emer S. Ferro, Mayara C. F. Gewehr, Ami Navon   +2 more
doaj   +1 more source

A lactobacilli-based inhaled live biotherapeutic product attenuates pulmonary neutrophilic inflammation

Nature Communications
Bronchopulmonary dysplasia (BPD) is a chronic lung disease of prematurity. Exposure to noxious stimuli such as hyperoxia, volutrauma, and infection in infancy can have long-reaching impacts on lung health and predispose towards the development of ...
Teodora Nicola, Nancy Wenger, Xin Xu, Michael Evans, Luhua Qiao, Gabriel Rezonzew, Youfeng Yang, Tamas Jilling, Camilla Margaroli, Kristopher Genschmer, Kent Willis, Namasivayam Ambalavanan, J. Edwin Blalock, Amit Gaggar, Charitharth Vivek Lal   +14 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Inibidor de protease

, 2016
Os inibidores de protease evitam a maturação das proteínas virais dentro das partículas de HIVEducação Superior::Ciências da Saúde ...
Howard Hughes Medical Institute (HHMI)
core   +2 more sources

Molecular basis of telaprevir resistance due to V36 and T54 mutations in the NS3-4A protease of the hepatitis C virus [PDF]

, 2008
Background The inhibitor telaprevir (VX-950) of the hepatitis C virus (HCV) protease NS3-4A has been tested in a recent phase 1b clinical trial in patients infected with HCV genotype 1. This trial revealed residue mutations that confer varying degrees of
Stefan Zeuzem, Albrecht, M., Hartmann, Christoph, Mayr, G., Andreas Schlicker, Welsch, C., Sarrazin, C., Susser, Simone, Sarrazin, Christoph, Lengauer, T., Albrecht, Mario, Christoph Welsch, Thomas Lengauer, Christoph Sarrazin, Antes, I., Mayr, Gabriele, Iris Antes, Simone Susser, Gabriele Mayr, Lengauer, Thomas, Susser, S., Zeuzem, S., Hartmann, C., Christoph Hartmann, Mario Albrecht, Schlicker, A., Francisco S Domingues, Domingues, Francisco S., Domingues, F., Welsch, Christoph, Schlicker, Andreas, Antes, Iris, Zeuzem, Stefan   +32 more
core   +1 more source

Genome-wide bioinformatics analysis of human protease capacity for proteolytic cleavage of the SARS-CoV-2 spike glycoprotein

Microbiology Spectrum
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) primarily enters the cell by binding the virus’s spike (S) glycoprotein to the angiotensin-converting enzyme 2 receptor on the cell surface, followed by proteolytic cleavage by host proteases ...
Evgenii V. Matveev, Gennady V. Ponomarev, Marat D. Kazanov   +2 more
doaj   +1 more source

Effect of temperature on germination and mobilization of protein reserves of three bread wheat cultivars [PDF]

علوم و فناوری بذر ایران, 2015
In order to investigate the effect of temperature on the mobilization of protein reserves of wheat cultivars and seedling traits a factorial experiment conducted based on a completely randomized design at seed technology laboratory of  the Faculty of ...
محمد صدقی
doaj